Gene: CCL15

6359
HCC-2|HMRP-2B|LKN-1|LKN1|MIP-1 delta|MIP-1D|MIP-5|MRP-2B|NCC-3|NCC3|SCYA15|SCYL3|SY15
C-C motif chemokine ligand 15
protein-coding
17q12
Ensembl:ENSG00000275718 MIM:601393 Vega:OTTHUMG00000188406 UniprotKB:Q16663
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.599e-1 (AD)  3.893e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACE20.729
DAZ40.721
DEFB4B0.651
OR4D90.647
TGIF2LY0.628
HYAL40.62
OR4K20.602
DEFB4A0.594
OR51A40.591
GIF0.583

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPLX3-0.313
ASPDH-0.308
NNAT-0.307
PARD6A-0.304
ATP2C2-0.301
SPEF1-0.299
NECAB2-0.295
KCNIP3-0.294
CRH-0.294
COL23A1-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of CCL15 mRNA19428942
D000082AcetaminophenAcetaminophen results in decreased expression of CCL15 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CCL15 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCL15 mRNA21632981|2164198
C006632arsenic trioxidearsenic trioxide results in increased expression of CCL15 mRNA15761015
D001379AzathioprineAzathioprine results in increased expression of CCL15 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCL15 mRNA20106945|2163298
D004958EstradiolEstradiol results in decreased expression of CCL15 mRNA20106945
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of CCL15 mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of CCL15 mRNA16197558
D016572CyclosporineCyclosporine results in decreased expression of CCL15 mRNA20106945
D004041Dietary FatsDietary Fats results in decreased expression of CCL15 mRNA21852083
C020748ferrous sulfateferrous sulfate results in decreased expression of CCL15 mRNA19428942
D011794QuercetinQuercetin results in decreased expression of CCL15 mRNA21632981
D014635Valproic AcidValproic Acid results in decreased methylation of CCL15 gene29154799
C016837zinc chloridezinc chloride results in decreased expression of CCL15 mRNA19428942

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS9346309  9548457  
GO:0008009chemokine activity-IBA21873635  
GO:0008201heparin binding-IEA-  
GO:0042056chemoattractant activity-IDA15001559  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0006874cellular calcium ion homeostasis-TAS9346309  
GO:0006935chemotaxis-TAS9600961  
GO:0006954inflammatory response-IBA21873635  
GO:0007165signal transduction-TAS9548457  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-TAS9548457  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0048245eosinophil chemotaxis-IBA21873635  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0050729positive regulation of inflammatory response-IBA21873635  
GO:0050918positive chemotaxis-IEA-  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005623cell-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23680692Circulating levels of immune and inflammatory markers and long versus short survival in early-stage lung cancer. (2013 Aug)Bodelon CAnn Oncol
28968774Occupational exposure to diesel engine exhaust and alterations in immune/inflammatory markers: a cross-sectional molecular epidemiology study in China. (2017 Oct 26)Bassig BACarcinogenesis