Gene info: ID 636

Gene: BICD1

GENE ID: 636

Synonyms: BICD

Description: BICD cargo adaptor 1

Gene type: protein-coding

Location: 12p11.21

dbXrefs: Ensembl:ENSG00000151746 MIM:602204 Vega:OTTHUMG00000169307 UniprotKB:Q96G01

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.072e-1 (AD) 1.473e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAB3GAP2	0.93
MTMR9	0.927
CAND1	0.925
SLC25A46	0.924
CLOCK	0.923
PPP2R5E	0.921
RANBP6	0.92
RLIM	0.916
BMPR2	0.915
KRAS	0.914

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.47
OR4F5	-0.451
OR4F29	-0.403
ANPEP	-0.399
MYOM1	-0.393
ASB4	-0.392
IL18RAP	-0.377
MMP9	-0.373
HIGD1B	-0.372
S100A12	-0.368

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICD1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BICD1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BICD1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICD1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BICD1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BICD1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of BICD1 mRNA	25458485
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of BICD1 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of BICD1 gene	25304211
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of BICD1 mRNA"	18687144
D001280	Atrazine	Atrazine results in decreased expression of BICD1 mRNA	22378314
D001374	Azacitidine	Azacitidine results in decreased expression of BICD1 mRNA	20823114
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BICD1 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of BICD1 mRNA	26238291
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of BICD1 mRNA	20823114
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of BICD1 mRNA	20660070
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of BICD1 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of BICD1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of BICD1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of BICD1 mRNA	29097150
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of BICD1 mRNA	15336504
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of BICD1 mRNA	18560533
D002330	Carmustine	Carmustine results in decreased expression of BICD1 mRNA	15980968
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of BICD1 mRNA	20823114
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of BICD1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of BICD1 mRNA	27392435
C118739	entinostat	entinostat results in increased expression of BICD1 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BICD1 mRNA"	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of BICD1 mRNA	29097150
D015025	Zearalenone	Zearalenone results in increased expression of BICD1 mRNA	19371625
D005557	Formaldehyde	Formaldehyde results in decreased expression of BICD1 mRNA	23649840
C069837	fullerene C60	fullerene C60 results in decreased expression of BICD1 mRNA	19167457
D019833	Genistein	Genistein results in increased expression of BICD1 mRNA	19371625
D007545	Isoproterenol	Isoproterenol results in increased expression of BICD1 mRNA	20003209
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of BICD1 mRNA	27392435
D008344	Maneb	[Paraquat co-treated with Maneb] affects the expression of BICD1 mRNA	22563483
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of BICD1 mRNA	20823114
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of BICD1 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of BICD1 mRNA	23179753
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of BICD1 mRNA	23649840
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of BICD1 protein	24625837
D010269	Paraquat	[Paraquat co-treated with Maneb] affects the expression of BICD1 mRNA	22563483
D010269	Paraquat	Paraquat results in increased expression of BICD1 mRNA	22563483
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of BICD1 mRNA	18593933
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BICD1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of BICD1 mRNA	26272509
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of BICD1 mRNA	20660070
C428725	pyridaben	pyridaben results in increased expression of BICD1 mRNA	22563483
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of BICD1 mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of BICD1 mRNA	19244175
D012906	Smoke	Smoke results in increased expression of BICD1 mRNA	21095227
C016104	sodium bichromate	sodium bichromate results in increased expression of BICD1 mRNA	22561333
D014212	Tretinoin	Tretinoin results in decreased expression of BICD1 mRNA	23724009
C012589	trichostatin A	trichostatin A results in decreased expression of BICD1 mRNA	24935251
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BICD1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of BICD1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of BICD1 mRNA	26272509\|2800136
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of BICD1 gene	25560391
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of BICD1 mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of BICD1 mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of BICD1 mRNA	27188386
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of BICD1 mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005200	structural constituent of cytoskeleton	-	TAS	9367685
GO:0005515	protein binding	-	IPI	17139249 20089649 21988832
GO:0008093	cytoskeletal adaptor activity	-	IDA	12447383
GO:0017137	Rab GTPase binding	-	IPI	12447383
GO:0019901	protein kinase binding	-	IPI	17139249
GO:0031871	proteinase activated receptor binding	-	ISS	20164183
GO:0034452	dynactin binding	-	IDA	12447383
GO:0034452	dynactin binding	-	IPI	17139249
GO:0045505	dynein intermediate chain binding	-	IDA	17139249
GO:0070840	dynein complex binding	-	IDA	12447383

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006396	RNA processing	-	TAS	9367685
GO:0008298	intracellular mRNA localization	-	NAS	9367685
GO:0009653	anatomical structure morphogenesis	-	TAS	9367685
GO:0016032	viral process	-	IMP	20089649
GO:0033365	protein localization to organelle	-	IDA	12447383 20089649
GO:0034063	stress granule assembly	-	ISS	-
GO:0048260	positive regulation of receptor-mediated endocytosis	-	IMP	20164183
GO:0070507	regulation of microtubule cytoskeleton organization	-	IGI	17139249
GO:0072385	minus-end-directed organelle transport along microtubule	-	IMP	12447383
GO:0072393	microtubule anchoring at microtubule organizing center	-	ISS	19825938
GO:1900275	negative regulation of phospholipase C activity	-	ISS	-
GO:1900276	regulation of proteinase activated receptor activity	-	ISS	-
GO:1900737	negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway	-	ISS	-
GO:1904781	positive regulation of protein localization to centrosome	-	IGI	17139249

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005794	Golgi apparatus	-	IDA	17562788
GO:0005794	Golgi apparatus	colocalizes_with	IDA	17139249
GO:0005802	trans-Golgi network	-	IDA	12447383 20089649
GO:0005813	centrosome	-	IMP	17139249
GO:0005829	cytosol	-	IDA	12447383
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	NAS	9367685
GO:0005881	cytoplasmic microtubule	colocalizes_with	IDA	20089649
GO:0016020	membrane	-	IDA	12447383
GO:0031410	cytoplasmic vesicle	-	IDA	12447383 20089649
GO:0045298	tubulin complex	colocalizes_with	TAS	20164183
GO:0048471	perinuclear region of cytoplasm	-	IDA	20089649
GO:0048471	perinuclear region of cytoplasm	-	IMP	17139249
GO:0072517	host cell viral assembly compartment	-	IDA	20089649

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-8856688	Golgi-to-ER retrograde transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25154699	Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. (2014 Oct)	Lee JH	Respir Med
21778810	Genetics of COPD. (2011 Sep)	Nakamura H	Allergol Int