Gene: CCL17

6361
A-152E5.3|ABCD-2|SCYA17|TARC
C-C motif chemokine ligand 17
protein-coding
16q21
Ensembl:ENSG00000102970 MIM:601520 Vega:OTTHUMG00000133468 UniprotKB:Q92583
NC_000016.10
PubMed
0   ANCO-SNPs
ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.359e-2 (AD)  4.280e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19546781chr16:57438715CCL17Promoter2.642e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPC1L10.631
FSCN30.623
TDRG10.577
LTA0.558
UCP30.521
PLA2G12B0.513
DCAF4L10.509
SESN20.509
TLR90.509
SRRM50.509

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPD1-0.28
CARF-0.278
CHP2-0.264
SNX22-0.258
BCHE-0.253
TSPAN8-0.253
KCNK17-0.252
HAPLN1-0.248
PLD5-0.246
METTL8-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of CCL17 mRNA19428942
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CCL17 mRNA19191707
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of CCL17 mRNA19191707
C496492abrineabrine results in increased expression of CCL17 mRNA22595364
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CCL17 protein]26138014
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCL17 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CCL17 protein"21135415
C547126AZM551248AZM551248 results in decreased expression of CCL17 mRNA22323515
C051597Bandrowski's baseBandrowski's base affects the expression of CCL17 mRNA18202158
D001542BenomylBenomyl results in increased expression of CCL17 mRNA27784618
D001542BenomylORMDL3 protein affects the reaction [Benomyl results in increased expression of CCL17 mRNA]27784618
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCL17 mRNA25908611
C006780bisphenol Abisphenol A results in decreased expression of CCL17 mRNA25181051
D001761BleomycinBleomycin results in increased expression of CCL17 mRNA26345256
D001761BleomycinBleomycin results in increased expression of CCL17 protein29175452
D019819BudesonideBudesonide results in decreased expression of CCL17 protein15679716
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of CCL17 mRNA19925653
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CCL17 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in increased secretion of CCL17 protein26138014
D002509CephaloridineCephaloridine results in increased expression of CCL17 mRNA18500788
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CCL17 mRNA28472532
D003035CobaltTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]23503329
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA23503329
C038459curdlancurdlan affects the expression of CCL17 mRNA19904525
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CCL17 protein22972382
C007262deoxynivalenoldeoxynivalenol results in increased expression of CCL17 mRNA22968694
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CCL17 mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of CCL17 mRNA21041162
D003907DexamethasoneTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]23503329
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA23503329
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CCL17 mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CCL17 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with TNF protein] results in increased expression of CCL17 mRNA23103562
C014477diflorasonediflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]15491423
C014477diflorasone"diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein]"15491423
C012125diisononyl phthalatediisononyl phthalate results in increased expression of CCL17 protein20064775
D004137Dinitrochlorobenzenediflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]15491423
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CCL17 mRNA23454147
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CCL17 protein15491423|2345414
D004137DinitrochlorobenzenePlant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 mRNA]23454147
D004137DinitrochlorobenzenePlant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]23454147
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CCL17 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL17 mRNA17942748
C020748ferrous sulfateferrous sulfate results in decreased expression of CCL17 mRNA19428942
C093230fexofenadinefexofenadine results in decreased expression of CCL17 mRNA21109747
C093230fexofenadinefexofenadine results in decreased expression of CCL17 protein21109747
D005411Flame RetardantsFlame Retardants results in increased expression of CCL17 protein22972382
C069837fullerene C60fullerene C60 results in increased expression of CCL17 mRNA20471445
C039281furanfuran results in increased expression of CCL17 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of CCL17 mRNA28973697
D017313FenretinideFenretinide results in increased expression of CCL17 mRNA28973697
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CCL17 mRNA16054899
D0150561-Methyl-3-isobutylxanthineTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]23503329
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA23503329
D007545IsoproterenolIsoproterenol results in decreased secretion of CCL17 protein12871855
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of CCL17 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCL17 mRNA26387944
D007840LatexLatex analog results in increased expression of CCL17 mRNA24768652
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CCL17 protein"23306164
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL17 mRNA16099135
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of CCL17 mRNA25266609
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CCL17 mRNA24213012
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CCL17 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCL17 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCL17 mRNA"25554681|2710602
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCL17 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of CCL17 protein"19371758
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCL17 mRNA"19836432|2491129
C031721naphthalenenaphthalene results in increased expression of CCL17 mRNA18978301
C015380neoechinulinneoechinulin results in decreased expression of CCL17 mRNA19818335
D009532NickelNickel results in increased expression of CCL17 mRNA24768652|2558310
D009532NickelTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]23503329
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA23503329
C028007nickel monoxidenickel monoxide results in increased expression of CCL17 mRNA19167457
C029938nickel sulfatenickel sulfate affects the expression of CCL17 mRNA18202158
C029938nickel sulfatenickel sulfate results in increased expression of CCL17 mRNA16166746
C052658oleanolic acid 3-acetateoleanolic acid 3-acetate inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL17 mRNA]23499868
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of CCL17 mRNA25658374
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of CCL17 mRNA25658374
D010126OzoneOzone results in increased expression of CCL17 mRNA12763052|2565837
D052638Particulate Matter[NFE2L2 gene mutant form affects the susceptibility to Particulate Matter] which results in increased expression of CCL17 protein18614404
D052638Particulate MatterParticulate Matter results in increased expression of CCL17 protein19074765
D010476PerfumePerfume results in increased expression of CCL17 mRNA24768652
C539933pevonedistatpevonedistat affects the expression of CCL17 mRNA24634471
D015232DinoprostoneDinoprostone results in increased expression of CCL17 mRNA16303787
C006253pirinixic acidpirinixic acid results in increased expression of CCL17 mRNA16985257
C442781plant extract, Houttuynia cordata"plant extract, Houttuynia cordata inhibits the reaction [[TNF protein co-treated with IL4 protein] results in increased expression of CCL17 mRNA]"18325701
C442781plant extract, Houttuynia cordata"plant extract, Houttuynia cordata inhibits the reaction [[TNF protein co-treated with IL4 protein] results in increased secretion of CCL17 protein]"18325701
D010936Plant ExtractsPlant Extracts inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of and results in increased activity of CCL17 protein]23454147
D010936Plant ExtractsPlant Extracts results in decreased expression of CCL17 mRNA23557933
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 mRNA]23454147
D010936Plant ExtractsPlant Extracts inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]23454147
D010936Plant ExtractsPlant Extracts results in decreased expression of CCL17 protein24216625
D010936Plant ExtractsPlant Extracts inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL17 mRNA]24216625
D010936Plant ExtractsPlant Extracts inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL17 protein]24216625
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CCL17 protein29175452
D011441PropylthiouracilPropylthiouracil results in decreased expression of CCL17 mRNA24780913
D011791QuartzQuartz results in increased expression of CCL17 mRNA19836432
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CCL17 mRNA16054899
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CCL17 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CCL17 mRNA19428942
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCL17 mRNA21602193
D012838SilymarinSilymarin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL17 mRNA]24216625
D012838SilymarinSilymarin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL17 protein]24216625
D012906SmokeSmoke results in increased expression of CCL17 mRNA23306164
D012906SmokeSmoke results in increased expression of CCL17 protein23306164
C017947sodium arsenitesodium arsenite results in decreased expression of CCL17 mRNA21911445
D053260SootSoot results in decreased expression of CCL17 mRNA19428942
D053260SootSoot results in increased expression of CCL17 mRNA22461453|2655175
D053260SootSoot results in increased expression of CCL17 protein21135415
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCL17 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCL17 mRNA17942748
C009495titanium dioxidetitanium dioxide results in increased expression of CCL17 mRNA21259345|2355797
C402696TMC 120ATMC 120A results in increased expression of CCL17 mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CCL17 mRNA20133372
D014051Toluene 2,4-Diisocyanate"diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein]"15491423
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein"15491423
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CCL17 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CCL17 mRNA"26179874
C022884undecaneundecane results in increased expression of CCL17 protein17337753
D014635Valproic AcidValproic Acid results in decreased expression of CCL17 mRNA19136453
D001335Vehicle Emissions[NFE2L2 gene mutant form affects the susceptibility to Vehicle Emissions] which results in increased expression of CCL17 protein18614404
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CCL17 gene25560391
D015032ZincTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA]23503329
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL17 mRNA23503329
C016837zinc chloridezinc chloride results in decreased expression of CCL17 mRNA19428942

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS8702936  9743322  
GO:0008009chemokine activity-IBA21873635  
GO:0031729CCR4 chemokine receptor binding-IEA-  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0006935chemotaxis-TAS9743322  
GO:0006954inflammatory response-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS8702936  
GO:0007267cell-cell signaling-TAS8702936  
GO:0007275multicellular organism development-TAS8702936  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0045662negative regulation of myoblast differentiation-IEA-  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27117830Treatment and monitoring of hypersensitivity pneumonitis. (2016 Sep)Miyazaki YExpert Rev Clin Immunol
27650194Abnormalities in chemokine levels in schizophrenia and their clinical correlates. (2017 Mar)Hong SSchizophr Res
24249745Circulating inflammation markers and prospective risk for lung cancer. (2013 Dec 18)Shiels MSJ Natl Cancer Inst
27020074An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder. (2016 Apr)Dennis PAJ Psychosom Res
19968631Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)Yang KDAllergy
25274579Cigarette smoking and variations in systemic immune and inflammation markers. (2014 Nov)Shiels MSJ Natl Cancer Inst
28950145Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma. (2017 Nov)Kinoshita TEur J Cancer
10846348Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments. (2000 Mar)Cheng YAKaohsiung J Med Sci
29065892The value of blood cytokines and chemokines in assessing COPD. (2017 Oct 24)Bradford ERespir Res