Gene: CCL18

6362
AMAC-1|AMAC1|CKb7|DC-CK1|DCCK1|MIP-4|PARC|SCYA18
C-C motif chemokine ligand 18
protein-coding
17q12
Ensembl:ENSG00000275385 MIM:603757 Vega:OTTHUMG00000188410 UniprotKB:P55774
NC_000017.11
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.976e-1 (AD)  5.467e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06040872chr17:34394215CCL184.580e-8Smoking28686328

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCGBP0.535
P2RY60.526
TREML40.524
DPEP30.501
SCIN0.486
CCR50.486
SFTPB0.485
IL21R0.481
CCL230.479
GPR840.474

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KREMEN2-0.277
ST6GAL2-0.272
FZD9-0.269
ABCB9-0.269
SLC16A11-0.258
DSCC1-0.254
GSG1-0.251
TM7SF2-0.248
KCNG2-0.239
SPDEF-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CCL18 mRNA"23146750
C056165acetovanilloneacetovanillone inhibits the reaction [arsenic trioxide results in increased secretion of CCL18 protein]18424721
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CCL18 protein]26138014
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CCL18 mRNA24449571
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of CCL18 mRNA19962721
D001151ArsenicArsenic results in decreased expression of CCL18 mRNA19962721
C006632arsenic trioxideacetovanillone inhibits the reaction [arsenic trioxide results in increased secretion of CCL18 protein]18424721
C006632arsenic trioxidearsenic trioxide results in increased expression of CCL18 mRNA19128835
C006632arsenic trioxidearsenic trioxide results in increased secretion of CCL18 protein18424721
C006632arsenic trioxideSB 203580 inhibits the reaction [arsenic trioxide results in increased secretion of CCL18 protein]18424721
C028031cadmium acetatecadmium acetate results in increased expression of CCL18 mRNA18155341
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CCL18 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CCL18 protein26138014
D016572CyclosporineCyclosporine results in increased methylation of CCL18 promoter27989131
D003703DemecolcineDemecolcine results in increased expression of CCL18 mRNA23649840
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of CCL18 mRNA17490981
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of CCL18 mRNA19962721
D005459FluoridesFluorides results in decreased expression of CCL18 mRNA19962721
D007840LatexLatex analog results in increased expression of CCL18 mRNA24768652
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL18 mRNA"23090859
C433788lipopolysaccharide, E. coli O26-B6"nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL18 mRNA]"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL18 mRNA26918785
D008070Lipopolysaccharides"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL18 mRNA]"26918785
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL18 mRNA23999131
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL18 mRNA]23999131
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL18 mRNA16099135
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL18 mRNA]"26918785
D009532NickelNickel results in increased expression of CCL18 mRNA24768652|2558310
C022838nickel chloride"nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL18 mRNA]"23090859
D052638Particulate MatterIL13 protein affects the reaction [Particulate Matter results in increased expression of CCL18 protein]16890758
D052638Particulate MatterParticulate Matter results in increased expression of CCL18 protein16890758
D010476PerfumePerfume results in increased expression of CCL18 mRNA24768652
C005556propionaldehydepropionaldehyde results in increased expression of CCL18 mRNA26079696
C093642SB 203580SB 203580 inhibits the reaction [arsenic trioxide results in increased secretion of CCL18 protein]18424721
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of CCL18 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL18 mRNA]23999131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCL18 mRNA23999131
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCL18 mRNA16979875
D001335Vehicle EmissionsIL13 protein affects the reaction [Vehicle Emissions results in increased expression of CCL18 protein]16890758
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CCL18 protein16890758
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCL18 mRNA16979875
D015034Zinc OxideZinc Oxide analog results in decreased expression of CCL18 mRNA27185063

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21481794  
GO:0008009chemokine activity-IBA21873635  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0006935chemotaxis-TAS9192897  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-TAS9192897  
GO:0007154cell communication-TAS9192897  
GO:0007165signal transduction-TAS9233607  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-TAS9233607  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0050729positive regulation of inflammatory response-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28348007Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. (2017 May 26)Li JCirc Res
27117830Treatment and monitoring of hypersensitivity pneumonitis. (2016 Sep)Miyazaki YExpert Rev Clin Immunol
19357939CCL18 production is decreased in alveolar macrophages from cigarette smokers. (2009 Jun)Kollert FInflammation
24835074Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis. (2014 Jul)Ohshimo SRespir Med