Gene: CCL19

6363
CKb11|ELC|MIP-3b|MIP3B|SCYA19
C-C motif chemokine ligand 19
protein-coding
9p13.3
Ensembl:ENSG00000172724 MIM:602227 Vega:OTTHUMG00000019833 UniprotKB:Q99731
NC_000009.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.271e-1 (AD)  5.091e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL14A10.805
COL8A10.797
TRABD2B0.791
GPX80.776
BMP50.76
S100A40.754
PKHD1L10.754
INMT0.749
OGN0.744
BMX0.741

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.383
C9orf24-0.383
YBX2-0.381
TMEM221-0.378
CABLES1-0.377
RHCG-0.376
BDH1-0.366
HAGHL-0.362
CA7-0.359
WIF1-0.357

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CCL19 mRNA"26377693
C0326681-nitropyrene1-nitropyrene results in decreased expression of CCL19 mRNA19428942
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CCL19 mRNA"23829299
C0453052,4-dinitrofluorobenzene sulfonic acid"2,4-dinitrofluorobenzene sulfonic acid results in increased expression of CCL19 mRNA"17936526
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of CCL19 mRNA"23829299
C496492abrineabrine results in decreased expression of CCL19 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of CCL19 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CCL19 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CCL19 mRNA23630614
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CCL19 mRNA24449571
D001151ArsenicArsenic affects the expression of CCL19 protein24675094
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of CCL19 mRNA19962721
D001151ArsenicArsenic results in decreased expression of CCL19 mRNA19962721
D001241AspirinAspirin results in increased expression of CCL19 mRNA11906190
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CCL19 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCL19 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCL19 mRNA21839799
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CCL19 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CCL19 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CCL19 mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of CCL19 mRNA19818335
C018475butyraldehydebutyraldehyde results in decreased expression of CCL19 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the expression of CCL19 mRNA18974090
D002211CapsaicinCapsaicin results in increased expression of CCL19 mRNA20349343
D002509CephaloridineCephaloridine results in increased expression of CCL19 mRNA18500788
C000488cladosporincladosporin results in increased expression of CCL19 mRNA19818335
D003035CobaltTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]23503329
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA23503329
D016572CyclosporineCyclosporine results in increased expression of CCL19 mRNA21865292
D003907DexamethasoneDexamethasone results in increased expression of CCL19 mRNA21041162
D003907DexamethasoneTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]23503329
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA23503329
C016366dibenzothiophenedibenzothiophene results in decreased expression of CCL19 mRNA23656968
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CCL19 mRNA21041162
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of CCL19 mRNA"27840820
D0198131,2-Dimethylhydrazine"APC protein affects the reaction [1,2-Dimethylhydrazine results in decreased expression of CCL19 mRNA]"27840820
D004391DustDust results in increased expression of CCL19 mRNA17805423
D005054EugenolEugenol results in increased expression of CCL19 mRNA17936526
C020748ferrous sulfateferrous sulfate results in decreased expression of CCL19 mRNA19428942
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of CCL19 mRNA19962721
D005459FluoridesFluorides results in decreased expression of CCL19 mRNA19962721
D005557FormaldehydeFormaldehyde results in increased expression of CCL19 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of CCL19 mRNA19167457
C039281furanfuran results in decreased expression of CCL19 mRNA25539665
C039281furanfuran results in increased expression of CCL19 mRNA26194646|2738771
D005839GentamicinsGentamicins results in decreased expression of CCL19 mRNA22061828
D0150561-Methyl-3-isobutylxanthineTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]23503329
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA23503329
D007840LatexLatex analog results in increased expression of CCL19 mRNA24768652
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL19 mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL19 mRNA15665042
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL19 mRNA16099135
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of CCL19 mRNA22563483
D008727MethotrexateMethotrexate results in decreased expression of CCL19 mRNA17400583
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CCL19 mRNA"25926378
D009151Mustard GasMustard Gas results in increased expression of CCL19 mRNA18988085
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of CCL19 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of CCL19 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCL19 mRNA"26683310
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CCL19 mRNA"25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CCL19 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCL19 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCL19 mRNA"25554681
C015380neoechinulinneoechinulin results in decreased expression of CCL19 mRNA19818335
C015380neoechinulinneoechinulin results in increased expression of CCL19 mRNA19818335
C490266neoechinulin Aneoechinulin A results in increased expression of CCL19 mRNA19818335
D009532NickelNickel results in increased expression of CCL19 mRNA24768652|2558310
D009532NickelTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]23503329
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA23503329
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of CCL19 mRNA22563483
D010269ParaquatParaquat results in increased expression of CCL19 mRNA22563483
D052638Particulate MatterParticulate Matter results in decreased expression of CCL19 mRNA23638009
D052638Particulate MatterParticulate Matter results in increased expression of CCL19 mRNA23638009
C410127PCB 180PCB 180 results in increased expression of CCL19 mRNA23829299
D010476PerfumePerfume results in increased expression of CCL19 mRNA24768652
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CCL19 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of CCL19 mRNA24780913
C428725pyridabenpyridaben results in increased expression of CCL19 mRNA22563483
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CCL19 mRNA19428942
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCL19 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCL19 mRNA22431001
D012969Sodium FluorideSodium Fluoride results in decreased expression of CCL19 mRNA27862939
D053260SootSoot results in decreased expression of CCL19 mRNA19428942
D053260SootSoot analog results in increased expression of CCL19 mRNA25056782
D053260SootSoot results in increased expression of CCL19 mRNA26551751
D013241SterigmatocystinSterigmatocystin results in increased expression of CCL19 mRNA19818335
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CCL19 mRNA21041162
C009495titanium dioxidetitanium dioxide results in increased expression of CCL19 mRNA21259345|2355797
C402696TMC 120ATMC 120A results in increased expression of CCL19 mRNA19818335
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CCL19 mRNA24096154
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CCL19 protein24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CCL19 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CCL19 protein]24096154
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CCL19 gene25560391
D015032ZincTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA]23503329
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CCL19 mRNA23503329
C016837zinc chloridezinc chloride results in decreased expression of CCL19 mRNA19428942

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA15778365  
GO:0031732CCR7 chemokine receptor binding-ISS-  
GO:0031735CCR10 chemokine receptor binding-IDA10706668  
GO:0042379chemokine receptor binding-IDA23341447  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO:0048020CCR chemokine receptor binding-IPI20002784  
GO ID GO Term Qualifier Evidence PubMed
GO:0001768establishment of T cell polarity-IDA12729902  
GO:0001771immunological synapse formation-ISS-  
GO:0002407dendritic cell chemotaxis-IDA15778365  
GO:0002408myeloid dendritic cell chemotaxis-IDA14592837  
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0002606positive regulation of dendritic cell antigen processing and presentation-ISS-  
GO:0006874cellular calcium ion homeostasis-TAS9153236  
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-NAS14592837  
GO:0006955immune response-TAS10861057  
GO:0007154cell communication-TAS9153236  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007257activation of JUN kinase activity-ISS-  
GO:0009615response to virus-TAS9153236  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010560positive regulation of glycoprotein biosynthetic process-ISS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0031295T cell costimulation-ISS-  
GO:0032735positive regulation of interleukin-12 production-ISS-  
GO:0032760positive regulation of tumor necrosis factor production-ISS-  
GO:0034695response to prostaglandin E-IDA14592837  
GO:0042102positive regulation of T cell proliferation-ISS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA15059845  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0043547positive regulation of GTPase activity-ISS-  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IDA15059845  15778365  
GO:0045627positive regulation of T-helper 1 cell differentiation-ISS-  
GO:0045807positive regulation of endocytosis-ISS-  
GO:0045860positive regulation of protein kinase activity-IDA14592837  15059845  
GO:0046330positive regulation of JNK cascade-IDA15778365  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0048260positive regulation of receptor-mediated endocytosis-ISS-  
GO:0048469cell maturation-ISS-  
GO:0050718positive regulation of interleukin-1 beta secretion-ISS-  
GO:0050921positive regulation of chemotaxis-ISS-  
GO:0051209release of sequestered calcium ion into cytosol-IDA14592837  
GO:0051897positive regulation of protein kinase B signaling-IDA15059845  15778365  
GO:0060491regulation of cell projection assembly-ISS-  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA15778365  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP25754930  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO:0071731response to nitric oxide-IDA16249377  
GO:0072610interleukin-12 secretion-ISS-  
GO:0090023positive regulation of neutrophil chemotaxis-IDA21051556  
GO:0097029mature conventional dendritic cell differentiation-ISS-  
GO:0098586cellular response to virus-IMP25754930  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IDA15059845  
GO:2000147positive regulation of cell motility-IDA15778365  
GO:2000549positive regulation of dendritic cell dendrite assembly-ISS-  
GO:2000669negative regulation of dendritic cell apoptotic process-IDA15059845  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6783783Interleukin-10 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24780137Smoking effect on chemokines of the human chronic periodontitis. (2014 Aug)Souto GRImmunobiology
26735770Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema. (2016 Jun 1)Faner RAm J Respir Crit Care Med
25249326Body mass index, physical activity, and serum markers of inflammation, immunity, and insulin resistance. (2014 Dec)Kitahara CMCancer Epidemiol Biomarkers Prev