Gene info: ID 6364

Gene: CCL20

GENE ID: 6364

Description: C-C motif chemokine ligand 20

Gene type: protein-coding

Location: 2q36.3

dbXrefs: Ensembl:ENSG00000115009 MIM:601960 Vega:OTTHUMG00000133189 UniprotKB:P78556

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 11

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.272e-1 (AD) 2.114e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MMP19	0.84
ZNF878	0.789
ICAM1	0.778
CD80	0.775
PLAUR	0.769
HELZ2	0.764
TNFAIP3	0.756
SPHK1	0.754
CALCA	0.754
SOCS1	0.753

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM179	-0.37
ASIC2	-0.361
SCRT1	-0.359
PPP1R16B	-0.359
AMER3	-0.357
OMG	-0.353
HCN2	-0.353
MYADML2	-0.346
CHRNB2	-0.344
RTN2	-0.343

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C032668	1-nitropyrene	1-nitropyrene results in increased expression of CCL20 mRNA	19428942\|1987928
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CCL20 mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CCL20 mRNA"	20566336
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CCL20 mRNA"	15059925
C003898	2-anisidine	2-anisidine affects the expression of CCL20 mRNA	28089782
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL20 mRNA"	28351761
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL20 mRNA"	23196670
C030682	3-chlorophenol	3-chlorophenol results in increased expression of CCL20 mRNA	18486366
C033643	3-nitrofluoranthene	3-nitrofluoranthene results in increased expression of CCL20 mRNA	19879285
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCL20 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCL20 mRNA"	27188386
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of CCL20 mRNA"	26238291
D000082	Acetaminophen	Acetaminophen results in increased expression of CCL20 mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of CCL20 mRNA	22461450
D000082	Acetaminophen	LGALS3 protein affects the reaction [Acetaminophen results in increased expression of CCL20 mRNA]	22461450
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of CCL20 mRNA	22385246
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CCL20 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CCL20 mRNA	27153756
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of CCL20 mRNA"	23195993
D000447	Aldehydes	Aldehydes results in increased expression of CCL20 mRNA	25014914
D019804	Mesalamine	[Mesalamine co-treated with Glucocorticoids] results in decreased expression of CCL20 mRNA	16306769
D019804	Mesalamine	Mesalamine results in decreased expression of [IL1B protein results in increased expression of CCL20 protein]	16306769
D019804	Mesalamine	Mesalamine results in decreased expression of [TNF protein results in increased expression of CCL20 protein]	16306769
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CCL20 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CCL20 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of CCL20 gene	25304211
D001151	Arsenic	Arsenic results in decreased expression of CCL20 mRNA	16835338
C006632	arsenic trioxide	[arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL20 mRNA	19828696
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of CCL20 mRNA"	18687144\|2416032
D001379	Azathioprine	Azathioprine results in decreased expression of CCL20 mRNA	19192274
D001379	Azathioprine	Azathioprine results in decreased expression of CCL20 protein	19192274
C547126	AZM551248	AZM551248 results in decreased expression of CCL20 mRNA	22323515
D001554	Benzene	Benzene affects the expression of CCL20 mRNA	21147609
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CCL20 mRNA	20106945\|2163298
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCL20 mRNA"	26238291
D004958	Estradiol	Estradiol affects the expression of CCL20 mRNA	25878060
D004958	Estradiol	Estradiol results in decreased expression of CCL20 mRNA	16298037
D004958	Estradiol	Estradiol results in increased expression of CCL20 mRNA	20106945\|2587806
C006780	bisphenol A	bisphenol A results in increased expression of CCL20 mRNA	25878060
C006780	bisphenol A	bisphenol A results in increased secretion of CCL20 protein	25878060
C006780	bisphenol A	bisphenol A affects the expression of CCL20 mRNA	27082013
C006780	bisphenol A	bisphenol A results in decreased expression of CCL20 mRNA	26911702
C006780	bisphenol A	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CCL20 mRNA]	27082013
C006780	bisphenol A	bisphenol A results in increased expression of CCL20 mRNA	25181051
C006794	brevianamide A	brevianamide A results in decreased expression of CCL20 mRNA	19818335
C006794	brevianamide A	brevianamide A results in increased expression of CCL20 mRNA	19818335
C018475	butyraldehyde	butyraldehyde results in increased expression of CCL20 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CCL20 mRNA	26472689
D002211	Capsaicin	Capsaicin results in increased expression of CCL20 protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]	22150557
D002509	Cephaloridine	Cephaloridine results in increased expression of CCL20 mRNA	18500788
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of CCL20 mRNA	21224055
D002713	Chlorine	Chlorine results in increased expression of CCL20 mRNA	24582687
D002737	Chloroprene	Chloroprene results in increased expression of CCL20 mRNA	23125180
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of CCL20 mRNA	28472532
C039671	ciglitazone	[ciglitazone binds to PPARG protein alternative form] which results in increased expression of CCL20 mRNA	16197558
C039671	ciglitazone	[ciglitazone binds to PPARG protein] which results in increased expression of CCL20 mRNA	16197558
C012843	cinnamic aldehyde	cinnamic aldehyde affects the expression of CCL20 mRNA	28219650
C000488	cladosporin	cladosporin results in decreased expression of CCL20 mRNA	19818335
C000488	cladosporin	cladosporin results in increased expression of CCL20 mRNA	21356202
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in increased expression of CCL20 mRNA	18078969
D003035	Cobalt	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]	23503329
D003035	Cobalt	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA	23503329
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CCL20 mRNA	19549813
C038459	curdlan	curdlan affects the expression of CCL20 mRNA	19904525
D016572	Cyclosporine	Cyclosporine affects the expression of CCL20 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of CCL20 mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in increased expression of CCL20 mRNA	23958496
D016572	Cyclosporine	Cyclosporine results in increased expression of CCL20 protein	21292993
C515055	darinaparsin	darinaparsin results in decreased expression of CCL20 mRNA	22535156
C515055	darinaparsin	Oxygen deficiency inhibits the reaction [darinaparsin results in decreased expression of CCL20 mRNA]	22535156
C014347	decitabine	decitabine results in increased expression of CCL20 mRNA	21856257
D003703	Demecolcine	Demecolcine results in increased expression of CCL20 mRNA	23649840
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of CCL20 mRNA	21224055
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCL20 mRNA	27757495
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCL20 mRNA	23326479
D003907	Dexamethasone	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]	23503329
D003907	Dexamethasone	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA	23503329
D003907	Dexamethasone	Dexamethasone inhibits the reaction [IL1B protein results in increased expression of CCL20 mRNA]	25851902
D003907	Dexamethasone	Dexamethasone inhibits the reaction [IL1B protein results in increased secretion of CCL20 protein]	25851902
C023614	dibenzofuran	dibenzofuran analog results in increased expression of CCL20 mRNA	20566336
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CCL20 mRNA	21266533
C058705	diethyl malate	diethyl malate affects the expression of CCL20 mRNA	24814887
D002117	Calcitriol	Calcitriol results in decreased expression of CCL20 mRNA	16002434
D002117	Calcitriol	Calcitriol results in increased expression of CCL20 mRNA	26485663
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of CCL20 mRNA	28219650
C521792	DMU-212	DMU-212 affects the expression of CCL20 mRNA	26428916
D004317	Doxorubicin	Doxorubicin results in increased expression of CCL20 mRNA	19915844
D004317	Doxorubicin	Razoxane inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]	19915844
D004391	Dust	Dust results in increased expression of CCL20 mRNA	17805423
D004726	Endosulfan	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CCL20 mRNA	26159488
D015025	Zearalenone	Zearalenone results in increased expression of CCL20 mRNA	25455459
C020748	ferrous sulfate	ferrous sulfate results in increased expression of CCL20 mRNA	19428942\|2154030
D005419	Flavonoids	Flavonoids results in increased expression of CCL20 mRNA	18035473
D005557	Formaldehyde	Formaldehyde results in increased expression of CCL20 mRNA	23649840
C070081	fulvestrant	fulvestrant results in increased expression of CCL20 mRNA	16298037
C056933	fumonisin B1	fumonisin B1 results in increased expression of CCL20 mRNA	27757495
C039281	furan	furan results in increased expression of CCL20 mRNA	27387713
C056507	gemcitabine	gemcitabine results in increased expression of CCL20 mRNA	17039268
D005938	Glucocorticoids	Glucocorticoids results in decreased expression of [IL1B protein results in increased expression of CCL20 protein]	16306769
D005938	Glucocorticoids	Glucocorticoids results in decreased expression of [TNF protein results in increased expression of CCL20 protein]	16306769
D005938	Glucocorticoids	[Mesalamine co-treated with Glucocorticoids] results in decreased expression of CCL20 mRNA	16306769
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of CCL20 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in increased expression of CCL20 mRNA	17109745
D005944	Glucosamine	IL1B promotes the reaction [Glucosamine results in increased expression of CCL20 mRNA]	17109745
D005978	Glutathione	Glutathione results in decreased expression of CCL20 mRNA	22385246
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in decreased expression of CCL20 mRNA	19192274
D006052	Gold Sodium Thiomalate	Gold Sodium Thiomalate results in decreased expression of CCL20 protein	19192274
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of CCL20 mRNA	15159207
D017313	Fenretinide	Fenretinide results in increased expression of CCL20 mRNA	15958647
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CCL20 protein	18441283
D006861	Hydrogen Peroxide	PTPN6 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of CCL20 protein]	18441283
D007200	Indican	Indican promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]	26259605
C075954	indolo(3,2-b)carbazole	"indolo(3,2-b)carbazole promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]"	26259605
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL20 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]	23503329
D015056	1-Methyl-3-isobutylxanthine	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA	23503329
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of CCL20 mRNA	17085751
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of CCL20 protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CCL20 mRNA	26387944
C561695	(+)-JQ1 compound	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of CCL20 mRNA	25119042
C410337	K 7174	K 7174 results in increased expression of CCL20 mRNA	24086573
D007840	Latex	Latex analog results in decreased expression of CCL20 mRNA	24768652
C045463	leflunomide	leflunomide results in increased expression of CCL20 mRNA	28988120
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL20 mRNA"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL20 protein"	16099135
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CCL20 mRNA"	11578593
C482199	lipopolysaccharide, E coli O55-B5	"pyrrolidine dithiocarbamic acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL20 mRNA]"	11578593
C442865	lipopolysaccharide, Helicobacter pylori	"DDIT3 protein inhibits the reaction [TLR2 protein promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CCL20 mRNA]]"	21220698
C442865	lipopolysaccharide, Helicobacter pylori	"[lipopolysaccharide, Helicobacter pylori results in decreased expression of TRIB3 mRNA] promotes the reaction [lipopolysaccharide, Helicobacter pylori results in increased expression of CCL20 mRNA]"	21220698
C442865	lipopolysaccharide, Helicobacter pylori	"lipopolysaccharide, Helicobacter pylori results in increased expression of CCL20 mRNA"	21220698
C442865	lipopolysaccharide, Helicobacter pylori	"lipopolysaccharide, Helicobacter pylori results in increased expression of CCL20 protein"	21220698
D008070	Lipopolysaccharides	HNRNPD protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL20 mRNA]	21135123
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL20 mRNA	15860229\|1819289
D008070	Lipopolysaccharides	AHR promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of CCL20 protein]	26259605
D008070	Lipopolysaccharides	AHR promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]	26259605
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [HDAC1 protein binds to CCL20 promoter]	26259605
D008070	Lipopolysaccharides	Lipopolysaccharides promotes the reaction [AHR protein binds to CCL20 promoter]	26259605
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL20 mRNA	21356202\|2625960
D008070	Lipopolysaccharides	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA	26259605
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CCL20 mRNA	16099135
C018091	maduramicin	maduramicin results in increased expression of CCL20 mRNA	29128925
D008558	Melphalan	Melphalan results in increased expression of CCL20 mRNA	22363485
C000600816	mercaptosteroid 4	mercaptosteroid 4 inhibits the reaction [IL1B protein results in increased expression of CCL20 mRNA]	25851902
C000600816	mercaptosteroid 4	mercaptosteroid 4 inhibits the reaction [IL1B protein results in increased secretion of CCL20 protein]	25851902
C000600817	mercaptosteroid 6	mercaptosteroid 6 inhibits the reaction [IL1B protein results in increased expression of CCL20 mRNA]	25851902
C000600817	mercaptosteroid 6	mercaptosteroid 6 inhibits the reaction [IL1B protein results in increased secretion of CCL20 protein]	25851902
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CCL20 mRNA	16507785
D008727	Methotrexate	Methotrexate results in decreased expression of CCL20 mRNA	19192274
D008727	Methotrexate	Methotrexate results in decreased expression of CCL20 protein	19192274
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CCL20 protein	28526320
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of CCL20 mRNA	25270620
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of CCL20 mRNA	19192274
D008775	Methylprednisolone	Methylprednisolone results in decreased expression of CCL20 protein	19192274
C500085	muraglitazar	muraglitazar results in decreased expression of CCL20 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in increased expression of CCL20 mRNA	25102026
D009173	Mycophenolic Acid	Mycophenolic Acid results in decreased expression of CCL20 mRNA	19818335
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of CCL20 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in decreased expression of CCL20 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in increased expression of CCL20 mRNA	19818335\|2135620
D009281	Naphthalenes	Naphthalenes results in increased expression of CCL20 protein	17337753
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]	22150557
C015380	neoechinulin	neoechinulin results in decreased expression of CCL20 mRNA	19818335
C015380	neoechinulin	neoechinulin results in increased expression of CCL20 mRNA	19818335
C490266	neoechinulin A	neoechinulin A results in decreased expression of CCL20 mRNA	19818335
C490266	neoechinulin A	neoechinulin A results in increased expression of CCL20 mRNA	19818335
D009532	Nickel	Nickel results in increased expression of CCL20 mRNA	23195993\|2476865
D009532	Nickel	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]	23503329
D009532	Nickel	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA	23503329
C022838	nickel chloride	nickel chloride results in increased expression of CCL20 mRNA	17312168
C029938	nickel sulfate	IL1A protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]	15679580
C029938	nickel sulfate	nickel sulfate results in increased secretion of CCL20 protein	15679580\|1609913
C029938	nickel sulfate	TNF protein affects the reaction [nickel sulfate results in increased secretion of CCL20 protein]	15679580
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of CCL20 mRNA	17616710
C558013	NSC 689534	NSC 689534 results in increased expression of CCL20 mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of CCL20 mRNA	25729387
D010100	Oxygen	Oxygen deficiency inhibits the reaction [darinaparsin results in decreased expression of CCL20 mRNA]	22535156
D010126	Ozone	IL13 protein affects the reaction [Ozone results in increased expression of CCL20 protein]	23434795
D010126	Ozone	Ozone results in increased expression of CCL20 mRNA	17095637\|1841751
D010126	Ozone	Ozone results in increased expression of CCL20 protein	23434795
D010126	Ozone	TNFRSF1B affects the reaction [Ozone results in increased expression of CCL20 protein]	23434795
D010269	Paraquat	Paraquat results in increased expression of CCL20 protein	18441283
D010269	Paraquat	PTPN6 protein inhibits the reaction [Paraquat results in increased expression of CCL20 protein]	18441283
D052638	Particulate Matter	Particulate Matter results in increased expression of CCL20 mRNA	21703343
D052638	Particulate Matter	Particulate Matter results in increased expression of CCL20 protein	21906792
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of CCL20 mRNA	18593933
C506614	PD 0325901	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of CCL20 mRNA	25119042
C506614	PD 0325901	PD 0325901 results in decreased expression of CCL20 mRNA	25119042
C046012	pentanal	pentanal results in increased expression of CCL20 mRNA	26079696
D010457	Peptidoglycan	Peptidoglycan results in increased expression of CCL20 mRNA	15860229
D010457	Peptidoglycan	Peptidoglycan results in increased expression of CCL20 protein	15191912
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of CCL20 mRNA	22237054
D010476	Perfume	Perfume results in increased expression of CCL20 mRNA	24768652
D015232	Dinoprostone	[Dinoprostone co-treated with IL1B] results in increased expression of CCL20	19273625
D015232	Dinoprostone	Dinoprostone promotes the reaction [IL23A results in increased expression of CCL20]	19273625
D015232	Dinoprostone	IL23A promotes the reaction [[Dinoprostone co-treated with IL1B] results in increased expression of CCL20]	19273625
D015232	Dinoprostone	Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]	17667525
D015232	Dinoprostone	Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein]	17667525
D010634	Phenobarbital	Phenobarbital affects the expression of CCL20 mRNA	19159669
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CCL20 mRNA	19710929
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCL20 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of CCL20 mRNA	19162173
D010894	Piroxicam	Piroxicam results in decreased expression of CCL20 mRNA	19192274
D010894	Piroxicam	Piroxicam results in decreased expression of CCL20 protein	19192274
D011137	Polystyrenes	Polystyrenes analog results in increased expression of CCL20 mRNA	25102311
C019536	potassium bromate	[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CCL20 mRNA]	27082013
C019536	potassium bromate	potassium bromate results in increased expression of CCL20 mRNA	23588252
D011192	Potassium Dichromate	Potassium Dichromate results in increased secretion of CCL20 protein	15679580
D011239	Prednisolone	Prednisolone results in decreased expression of CCL20 mRNA	19192274
D011239	Prednisolone	Prednisolone results in decreased expression of CCL20 protein	19192274
C005556	propionaldehyde	propionaldehyde results in increased expression of CCL20 mRNA	26079696
C010313	pseudocumene	pseudocumene results in increased expression of CCL20 protein	17337753
C020972	pyrrolidine dithiocarbamic acid	"pyrrolidine dithiocarbamic acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL20 mRNA]"	11578593
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of CCL20 mRNA	14699072
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL20 mRNA	19059307
D011929	Razoxane	Razoxane inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]	19915844
C059514	resveratrol	resveratrol results in decreased susceptibility to CCL20 protein	21340626
C059514	resveratrol	resveratrol results in decreased expression of CCL20 mRNA	23419489
D019438	Ritonavir	Ritonavir results in decreased expression of CCL20	26626330
C116926	rofecoxib	Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]	17667525
C116926	rofecoxib	Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein]	17667525
C116926	rofecoxib	rofecoxib results in increased expression of CCL20 mRNA	17667525
C116926	rofecoxib	rofecoxib results in increased expression of CCL20 protein	17667525
C089730	rosiglitazone	rosiglitazone results in decreased expression of CCL20 mRNA	21515302
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of CCL20 mRNA"	24160326
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CCL20 mRNA	23806026\|2589566
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CCL20 mRNA	19428942\|2154030
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CCL20 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CCL20 mRNA	22431001
D019821	Simvastatin	Simvastatin results in decreased expression of CCL20 mRNA	22305382
C439060	sirtinol	sirtinol results in increased expression of CCL20 mRNA	22385246
C017947	sodium arsenite	sodium arsenite results in increased expression of CCL20 mRNA	28595984
C017947	sodium arsenite	sodium arsenite results in increased expression of CCL20 mRNA	21911445
C016104	sodium bichromate	sodium bichromate results in decreased expression of CCL20 mRNA	22561333
C016104	sodium bichromate	sodium bichromate results in increased expression of CCL20 mRNA	22561333
D012967	Sodium Dodecyl Sulfate	IL1A protein affects the reaction [Sodium Dodecyl Sulfate results in increased secretion of CCL20 protein]	15679580
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased secretion of CCL20 protein	15679580
D012967	Sodium Dodecyl Sulfate	TNF protein affects the reaction [Sodium Dodecyl Sulfate results in increased secretion of CCL20 protein]	15679580
D053260	Soot	Soot results in increased expression of CCL20 mRNA	19428942
D053260	Soot	Soot results in increased expression of CCL20 mRNA	22461453
D013241	Sterigmatocystin	Sterigmatocystin results in decreased expression of CCL20 mRNA	19818335
C016766	sulforafan	sulforafan results in increased expression of CCL20 mRNA	26833863
D013458	Sulfur Dioxide	Sulfur Dioxide results in decreased expression of CCL20 protein	27565714
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]	22150557
D016559	Tacrolimus	Tacrolimus results in increased expression of CCL20 mRNA	23958496
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in increased expression of CCL20 mRNA	19059307
D013629	Tamoxifen	Tamoxifen results in decreased expression of CCL20 mRNA	16298037
D013656	Taurocholic Acid	EGR1 promotes the reaction [Taurocholic Acid results in increased expression of CCL20 mRNA]	21224055
D013656	Taurocholic Acid	Taurocholic Acid results in increased expression of CCL20 mRNA	21224055
D000068698	Tenofovir	Tenofovir results in increased expression of and results in increased secretion of CCL20 protein	24205323
D000068698	Tenofovir	Tenofovir results in increased expression of CCL20 mRNA	24205323
D013749	Tetrachlorodibenzodioxin	[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CCL20 mRNA	26159488
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CCL20 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CCL20 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	AHR promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of and results in increased secretion of CCL20 protein]	26259605
D013749	Tetrachlorodibenzodioxin	AHR promotes the reaction [[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]	26259605
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CCL20 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of CCL20 mRNA	26259605
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA	26259605
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]	26259605
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CCL20 mRNA	19933214\|2625960
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CCL20 mRNA	19945525
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL20 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of CCL20 mRNA	21259345\|2355797
C402696	TMC 120A	TMC 120A results in decreased expression of CCL20 mRNA	19818335
C402696	TMC 120A	TMC 120A results in increased expression of CCL20 mRNA	19818335
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CCL20 mRNA	27404394
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CCL20 mRNA	27865774
D014028	Tobacco Smoke Pollution	NFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of CCL20 mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CCL20 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of and results in increased secretion of CCL20 protein	24752502
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CCL20 mRNA	24752502
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of CCL20 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of CCL20 mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CCL20 mRNA"	19682533
D014212	Tretinoin	[arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL20 mRNA	19828696
D014212	Tretinoin	Tretinoin results in increased expression of CCL20 mRNA	19828696
D014212	Tretinoin	Tretinoin results in increased expression of CCL20 protein	19828696
D014212	Tretinoin	Tretinoin results in increased expression of CCL20 mRNA	20488242
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CCL20 mRNA	19042947
C057693	troglitazone	troglitazone results in increased expression of CCL20 mRNA	19140230
C057693	troglitazone	troglitazone results in decreased expression of CCL20 mRNA	21515302
C046243	tryptanthrine	tryptanthrine promotes the reaction [[AHR protein binds to ARNT protein] which binds to CCL20 promoter]	26259605
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in increased expression of CCL20 mRNA	18078969
C022884	undecane	undecane results in increased expression of CCL20 protein	17337753
D014635	Valproic Acid	Valproic Acid results in increased expression of CCL20 mRNA	28001369\|2915479
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CCL20 protein	21906792
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of CCL20 gene	25560391
D014750	Vincristine	Vincristine results in increased expression of CCL20 mRNA	23649840
D009536	Niacinamide	Niacinamide results in increased expression of CCL20 mRNA	22385246
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCL20 mRNA"	27188386
C111237	vorinostat	vorinostat results in decreased expression of CCL20 mRNA	18769122
C111237	vorinostat	vorinostat results in increased expression of CCL20 mRNA	18769122
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of CCL20 mRNA	18593933
D015032	Zinc	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA]	23503329
D015032	Zinc	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL20 mRNA	23503329
D015032	Zinc	Zinc deficiency results in increased expression of CCL20 mRNA	11717422
C016837	zinc chloride	zinc chloride results in increased expression of CCL20 mRNA	19428942\|2154030
C088658	zoledronic acid	zoledronic acid results in increased expression of CCL20 mRNA	20977926\|2471476
D015054	Zymosan	Zymosan results in increased expression of CCL20 protein	15191912

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	17703191 18239685
GO:0008009	chemokine activity	-	IBA	21873635
GO:0031731	CCR6 chemokine receptor binding	-	IDA	12081481 20068036
GO:0048020	CCR chemokine receptor binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002548	monocyte chemotaxis	-	IBA	21873635
GO:0006935	chemotaxis	-	IDA	20068036
GO:0006954	inflammatory response	-	IBA	21873635
GO:0006955	immune response	-	TAS	10521347
GO:0007165	signal transduction	-	TAS	9038201
GO:0007186	G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007267	cell-cell signaling	-	TAS	9038201
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0030593	neutrophil chemotaxis	-	IBA	21873635
GO:0035584	calcium-mediated signaling using intracellular calcium source	-	IDA	25122636
GO:0042060	wound healing	-	IEA	-
GO:0042742	defense response to bacterium	-	IEA	-
GO:0043547	positive regulation of GTPase activity	-	IBA	21873635
GO:0048247	lymphocyte chemotaxis	-	IBA	21873635
GO:0050726	positive regulation of interleukin-1 alpha biosynthetic process	-	IEA	-
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	-	IEA	-
GO:0060326	cell chemotaxis	-	IDA	23765988
GO:0070098	chemokine-mediated signaling pathway	-	IBA	21873635
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0071222	cellular response to lipopolysaccharide	-	IEA	-
GO:0071223	cellular response to lipoteichoic acid	-	IEA	-
GO:0071346	cellular response to interferon-gamma	-	IBA	21873635
GO:0071347	cellular response to interleukin-1	-	IBA	21873635
GO:0071356	cellular response to tumor necrosis factor	-	IBA	21873635
GO:0072678	T cell migration	-	ISS	-
GO:0072679	thymocyte migration	-	ISS	-
GO:2000406	positive regulation of T cell migration	-	IDA	23620790

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IBA	21873635
GO:0005622	intracellular	-	IEA	-

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway
hsa05323	Rheumatoid arthritis

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-380108	Chemokine receptors bind chemokines	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24780137	Smoking effect on chemokines of the human chronic periodontitis. (2014 Aug)	Souto GR	Immunobiology
21430224	The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation. (2011 May 1)	Demoor T	J Immunol
21931826	Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells. (2011)	Aldhous MC	PLoS One
20368170	Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. (2009 Oct 28)	Shan M	Sci Transl Med
29055885	Industrial hog farming is associated with altered circulating immunological markers. (2018 Mar)	Hofmann JN	Occup Environ Med
25864589	Tobacco smoke induces production of chemokine CCL20 to promote lung cancer. (2015 Jul 10)	Wang GZ	Cancer Lett
21537330	Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT. (2011 Jul)	Verschuere S	Lab Invest
28753646	Associations between self-reported diabetes and 78 circulating markers of inflammation, immunity, and metabolism among adults in the United States. (2017)	Van Dyke AL	PLoS One
25306249	The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. (2014 Oct 12)	Carolan BJ	Respir Res
18230951	Decreased cytokine and chemokine mRNA expression in bronchoalveolar lavage in asymptomatic smoking subjects. (2008)	Meuronen A	Respiration
19445658	Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation. (2009 May 15)	De Swert KO	Respir Res