Gene: CCL21

6366
6Ckine|CKb9|ECL|SCYA21|SLC|TCA4
C-C motif chemokine ligand 21
protein-coding
9p13.3
Ensembl:ENSG00000137077 MIM:602737 Vega:OTTHUMG00000019838 UniprotKB:O00585
NC_000009.12
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.916e-1 (AD)  5.563e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFF30.732
SCNN1B0.711
SLC26A70.706
IYD0.705
TPO0.696
FOXE10.691
KRT70.674
SCNN1A0.662
COL14A10.657
TG0.65

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM53-0.352
CCDC24-0.317
CCDC151-0.316
B9D2-0.31
HDDC3-0.309
UCN-0.304
ASPDH-0.303
FEZF2-0.299
GDF9-0.299
FBXO15-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of CCL21 mRNA19428942
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CCL21 mRNA"23829299
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of CCL21 mRNA25088246
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CCL21 gene27153756
D001151ArsenicArsenic affects the expression of CCL21 protein24675094
D001151Arsenic[Arsenic co-treated with Fluorides] results in decreased expression of CCL21 mRNA19962721
D001151ArsenicArsenic results in decreased expression of CCL21 mRNA19962721
D017636Asbestos, Amphibole"Asbestos, Amphibole affects the expression of CCL21 protein"20855422
D004958EstradiolEstradiol results in decreased expression of CCL21 mRNA18692832
C006780bisphenol Abisphenol A results in decreased expression of CCL21 mRNA25181051
C016274bromoacetatebromoacetate results in decreased expression of CCL21 mRNA19753638
D004041Dietary FatsDietary Fats affects the expression of CCL21 mRNA18457598
D004237DiuronDiuron results in increased expression of CCL21 mRNA21551480
D015025ZearalenoneZearalenone results in increased expression of CCL21 mRNA27757495
D005290Ferric CompoundsFerric Compounds results in increased expression of CCL21 mRNA24035972
C020748ferrous sulfateferrous sulfate results in decreased expression of CCL21 mRNA19428942
D005459Fluorides[Arsenic co-treated with Fluorides] results in decreased expression of CCL21 mRNA19962721
D005459FluoridesFluorides results in decreased expression of CCL21 mRNA19962721
C039281furanfuran results in increased expression of CCL21 mRNA27387713
D017313FenretinideFenretinide results in increased expression of CCL21 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of CCL21 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCL21 mRNA25613284
D007840LatexLatex analog results in increased expression of CCL21 mRNA24768652
D008070Lipopolysaccharides[usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL21 mRNA22777745
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of CCL21 mRNA22563483
D008727MethotrexateMethotrexate results in decreased expression of CCL21 mRNA17400583
D009532NickelNickel results in increased expression of CCL21 mRNA24768652|2558310
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of CCL21 mRNA22563483
D010269ParaquatParaquat results in increased expression of CCL21 mRNA22563483
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CCL21 mRNA18804290
D010476PerfumePerfume results in increased expression of CCL21 mRNA24768652
D011372ProgestinsProgestins results in decreased expression of CCL21 mRNA19609016
C005556propionaldehydepropionaldehyde results in decreased expression of CCL21 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CCL21 mRNA24780913
C059514resveratrolresveratrol results in increased expression of CCL21 mRNA25905778
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CCL21 mRNA19428942
D018038Sodium SeleniteSodium Selenite results in increased expression of CCL21 mRNA18175754
D053260SootSoot results in decreased expression of CCL21 mRNA19428942
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCL21 mRNA25613284
C073339usnic acid[usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL21 mRNA22777745
C073339usnic acidusnic acid results in increased expression of CCL21 mRNA21953288|2277774
D014635Valproic AcidValproic Acid results in decreased methylation of CCL21 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of CCL21 mRNA23034163
D017967Zinc CompoundsZinc Compounds results in increased expression of CCL21 mRNA24035972

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14978162  
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA15778365  18308860  
GO:0031732CCR7 chemokine receptor binding-ISS-  
GO:0042379chemokine receptor binding-IDA23341447  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001768establishment of T cell polarity-IDA12729902  
GO:0001771immunological synapse formation-ISS-  
GO:0001954positive regulation of cell-matrix adhesion-IDA15569314  18308860  
GO:0002407dendritic cell chemotaxis-IDA15778365  
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0002606positive regulation of dendritic cell antigen processing and presentation-ISS-  
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-NAS14592837  
GO:0006955immune response-TAS10861057  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IDA18308860  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007267cell-cell signaling-TAS9235955  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010560positive regulation of glycoprotein biosynthetic process-ISS-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0030838positive regulation of actin filament polymerization-IDA11242036  
GO:0031274positive regulation of pseudopodium assembly-IDA11242036  
GO:0031295T cell costimulation-ISS-  
GO:0031529ruffle organization-IDA15569314  
GO:0033630positive regulation of cell adhesion mediated by integrin-IDA15569314  
GO:0034695response to prostaglandin E-IDA14592837  
GO:0035759mesangial cell-matrix adhesion-IDA15569314  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA15059845  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IDA15059845  15778365  
GO:0045860positive regulation of protein kinase activity-IDA15059845  
GO:0046330positive regulation of JNK cascade-IDA15778365  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0048260positive regulation of receptor-mediated endocytosis-ISS-  
GO:0048469cell maturation-ISS-  
GO:0050921positive regulation of chemotaxis-ISS-  
GO:0051209release of sequestered calcium ion into cytosol-IDA14592837  
GO:0051491positive regulation of filopodium assembly-IDA15569314  
GO:0051897positive regulation of protein kinase B signaling-IDA15059845  15778365  
GO:0060326cell chemotaxis-IDA18308860  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA12729902  15778365  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO:0090023positive regulation of neutrophil chemotaxis-IDA21051556  
GO:0090630activation of GTPase activity-IDA15778365  
GO:0097026dendritic cell dendrite assembly-ISS-  
GO:1903237negative regulation of leukocyte tethering or rolling-IDA18308860  
GO:2000147positive regulation of cell motility-IDA15778365  
GO:2000406positive regulation of T cell migration-IDA23620790  
GO:2000529positive regulation of myeloid dendritic cell chemotaxis-IDA14592837  
GO:2000548negative regulation of dendritic cell dendrite assembly-ISS-  
GO:2000669negative regulation of dendritic cell apoptotic process-IDA15059845  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005623cell-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23895590Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells. (2013 Dec)Parlet CPAlcohol Clin Exp Res
28753646Associations between self-reported diabetes and 78 circulating markers of inflammation, immunity, and metabolism among adults in the United States. (2017)Van Dyke ALPLoS One
23758732Increased number and altered phenotype of lymphatic vessels in peripheral lung compartments of patients with COPD. (2013 Jun 11)Mori MRespir Res
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis