Gene: CCL22

6367
A-152E5.1|ABCD-1|DC/B-CK|MDC|SCYA22|STCP-1
C-C motif chemokine ligand 22
protein-coding
16q21
Ensembl:ENSG00000102962 MIM:602957 Vega:OTTHUMG00000133454 UniprotKB:O00626
NC_000016.10
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.368e-1 (AD)  6.119e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPX60.637
OR7A170.624
OR12D10.606
OR10G20.596
HOXD120.567
OR5D140.544
CYP1A20.533
CT45A10.531
C11orf530.529
CWH430.524

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH2-0.312
CCDC87-0.295
EFR3B-0.287
C10orf82-0.284
ZNF891-0.282
CLDN16-0.27
PCDHAC2-0.267
PLEKHD1-0.266
TRIM67-0.264
MARCH10-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CCL22 mRNA19191707
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CCL22 mRNA]19350554
C014949acetylhydrazineacetylhydrazine results in decreased expression of CCL22 mRNA15282401
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CCL22 mRNA16483693
D001151ArsenicCCL22 mRNA results in decreased susceptibility to Arsenic17976673
C006632arsenic trioxideAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CCL22 mRNA]19350554
C006632arsenic trioxide[arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL22 mRNA19828696
C006632arsenic trioxidearsenic trioxide results in decreased expression of CCL22 mRNA19128835|1935055
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CCL22 protein"21135415
C051597Bandrowski's baseBandrowski's base affects the expression of CCL22 mRNA18202158
C006780bisphenol Abisphenol A affects the expression of CCL22 mRNA25181051
D002211CapsaicinCapsaicin results in increased expression of CCL22 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]22150557
C023600chromic oxidechromic oxide analog results in increased secretion of CCL22 protein24885771
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of CCL22 mRNA28219650
D003471CuprizoneCuprizone results in decreased expression of CCL22 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CCL22 protein22972382
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CCL22 mRNA23914054
C007262deoxynivalenoldeoxynivalenol results in increased expression of CCL22 mRNA22968694
C451162Dermatophagoides pteronyssinus antigen p 1CD80 protein affects the reaction [Particulate Matter analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
C451162Dermatophagoides pteronyssinus antigen p 1CD80 protein affects the reaction [Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
C451162Dermatophagoides pteronyssinus antigen p 1CD86 protein affects the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]12023397
C451162Dermatophagoides pteronyssinus antigen p 1CD86 protein affects the reaction [Particulate Matter analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
C451162Dermatophagoides pteronyssinus antigen p 1CD86 protein affects the reaction [Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
C451162Dermatophagoides pteronyssinus antigen p 1Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 mRNA12023397
C451162Dermatophagoides pteronyssinus antigen p 1Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein12023397
C451162Dermatophagoides pteronyssinus antigen p 1Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 mRNA]12023397
C451162Dermatophagoides pteronyssinus antigen p 1Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]12023397
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CCL22 mRNA28962523
D004041Dietary FatsDietary Fats affects the expression of CCL22 protein19680557
C012125diisononyl phthalatediisononyl phthalate results in increased expression of CCL22 protein20064775
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CCL22 protein17719030
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of CCL22 mRNA28219650
D004298DopamineDopamine results in decreased expression of CCL22 mRNA25818600
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CCL22 mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of CCL22 mRNA27757495
C000499ferric oxideferric oxide results in increased secretion of CCL22 protein24885771
C093230fexofenadinefexofenadine results in decreased expression of CCL22 mRNA21109747
C093230fexofenadinefexofenadine results in decreased expression of CCL22 protein21109747
D005411Flame RetardantsFlame Retardants results in increased expression of CCL22 protein22972382
D005419FlavonoidsFlavonoids results in increased expression of CCL22 mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of CCL22 mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of CCL22 mRNA20471445
C579046GDC-0152GDC-0152 results in increased expression of CCL22 protein22956632
D005839GentamicinsGentamicins results in decreased expression of CCL22 mRNA22061828
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of CCL22 mRNA]17109745
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of CCL22 protein22972382
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CCL22 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL22 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CCL22 mRNA26387944
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CCL22 mRNA]26582142
D007840LatexLatex analog results in increased expression of CCL22 mRNA24768652
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CCL22 protein"23306164
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [Shiga Toxin 2 results in increased secretion of CCL22 protein]16366002
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CCL22 mRNA]26582142
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL22 mRNA15665042|2658214
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CCL22 mRNA16099135
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CCL22 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CCL22 mRNA26378955
C551151manganese ferritemanganese ferrite results in increased secretion of CCL22 protein24885771
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CCL22 mRNA23649840
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of CCL22 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CCL22 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCL22 protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of CCL22 protein"19371758
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CCL22 mRNA"24911292
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]22150557
C015380neoechinulinneoechinulin results in decreased expression of CCL22 mRNA19818335
C015380neoechinulinneoechinulin results in increased expression of CCL22 mRNA19818335
D009532NickelNickel results in increased expression of CCL22 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased secretion of CCL22 protein18437699
C022838nickel chloridenickel chloride affects the expression of CCL22 mRNA24670797
C028007nickel monoxidenickel monoxide results in increased expression of CCL22 mRNA19167457
C029938nickel sulfatenickel sulfate affects the expression of CCL22 mRNA18202158
C029938nickel sulfatenickel sulfate results in increased expression of CCL22 mRNA12060402
C029938nickel sulfatenickel sulfate results in increased expression of CCL22 mRNA16166746
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCL22 mRNA"19013360
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CCL22 mRNA25658374
D000073878Palm OilPalm Oil affects the expression of CCL22 protein19680557
D052638Particulate MatterCD80 protein affects the reaction [Particulate Matter analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
D052638Particulate MatterCD86 protein affects the reaction [Particulate Matter analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
D052638Particulate MatterParticulate Matter results in increased expression of CCL22 mRNA21708214
D010476PerfumePerfume results in increased expression of CCL22 mRNA24768652
C539933pevonedistatpevonedistat affects the expression of CCL22 mRNA24634471
D015232DinoprostoneDinoprostone results in increased expression of CCL22 mRNA16303787
D010936Plant ExtractsPlant Extracts results in decreased expression of CCL22 mRNA23557933
D010936Plant ExtractsPlant Extracts inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL22 mRNA]24216625
D010936Plant ExtractsPlant Extracts inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL22 protein]24216625
D011441PropylthiouracilPropylthiouracil results in decreased expression of CCL22 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of CCL22 mRNA23224687
D022641Shiga Toxin 2Lipopolysaccharides promotes the reaction [Shiga Toxin 2 results in increased secretion of CCL22 protein]16366002
D022641Shiga Toxin 2Shiga Toxin 2 results in increased secretion of CCL22 protein16366002
D012822Silicon DioxideSilicon Dioxide results in increased expression of CCL22 mRNA23221170
D012838SilymarinSilymarin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL22 mRNA]24216625
D012838SilymarinSilymarin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL22 protein]24216625
D012906SmokeSmoke results in increased expression of CCL22 mRNA23306164
D012906SmokeSmoke results in increased expression of CCL22 protein23306164
D012906SmokeSmoke results in increased secretion of CCL22 protein17041012
D012969Sodium FluorideSodium Fluoride results in increased expression of CCL22 mRNA21340527
D053260SootSoot results in increased expression of CCL22 protein21135415
D013241SterigmatocystinSterigmatocystin results in increased expression of CCL22 mRNA19818335
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CCL22 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CCL22 mRNA26378955
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]22150557
C013698tallowtallow affects the expression of CCL22 protein19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCL22 mRNA21570461|2637764
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL22 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CCL22 mRNA21259345
C402696TMC 120ATMC 120A results in increased expression of CCL22 mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CCL22 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CCL22 protein24632068
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of and results in increased secretion of CCL22 protein27818348
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CCL22 protein27793746
D014212Tretinoin[arsenic trioxide co-treated with Tretinoin] results in increased expression of CCL22 mRNA19828696
D014212TretinoinTretinoin results in increased expression of CCL22 mRNA19828696
D014212TretinoinTretinoin results in increased expression of CCL22 protein19828696
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CCL22 mRNA17183730
D001335Vehicle EmissionsCD80 protein affects the reaction [Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
D001335Vehicle EmissionsCD86 protein affects the reaction [Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
D001335Vehicle EmissionsVehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 mRNA]12023397
D001335Vehicle EmissionsVehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]12023397
D014750VincristineVincristine results in increased expression of CCL22 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008009chemokine activity-IBA21873635  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0006935chemotaxis-TAS10861057  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-TAS10861057  
GO:0007165signal transduction-TAS9743322  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007267cell-cell signaling-TAS9151897  
GO:0009615response to virus-TAS9381181  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0048245eosinophil chemotaxis-IBA21873635  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27477800Low-grade disease activity in early life precedes childhood asthma and allergy. (2016 Aug)Chawes BLDan Med J
27650194Abnormalities in chemokine levels in schizophrenia and their clinical correlates. (2017 Mar)Hong SSchizophr Res
24249745Circulating inflammation markers and prospective risk for lung cancer. (2013 Dec 18)Shiels MSJ Natl Cancer Inst
26424214Plasma Chemokine signature correlates with lung goblet cell hyperplasia in smokers with and without chronic obstructive pulmonary disease. (2015 Sep 30)Kim VBMC Pulm Med
29055885Industrial hog farming is associated with altered circulating immunological markers. (2018 Mar)Hofmann JNOccup Environ Med
19968631Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)Yang KDAllergy
25970596Altered activation of innate immunity associates with white matter volume and diffusion in first-episode psychosis. (2015)Mantyla TPLoS One