Gene: CCL23

6368
CK-BETA-8|CKb8|Ckb-8|Ckb-8-1|MIP-3|MIP3|MPIF-1|SCYA23|hmrp-2a
C-C motif chemokine ligand 23
protein-coding
17q12
Ensembl:ENSG00000274736 MIM:602494 Vega:OTTHUMG00000188409 UniprotKB:P55773
NG_029876.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.631e-1 (AD)  3.679e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24325790chr17:34345392CCL23Promoter5.388e-4Alcohol use disorders26763658

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM129A0.587
MAP7D30.551
IQGAP20.547
TREML40.541
COL3A10.53
ECSCR0.524
NCF20.523
PLBD10.517
MYOF0.516
MNDA0.513

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROG2-0.309
C19orf73-0.307
ASPDH-0.301
ATP2C2-0.293
HAGHL-0.286
MAGIX-0.284
HYAL3-0.281
CHRNA4-0.277
MFSD3-0.274
GAL3ST3-0.273

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CCL23 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of CCL23 mRNA15761015
C006780bisphenol Abisphenol A results in decreased expression of CCL23 mRNA28079927
D017332Cetirizine[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CCL23 protein25020133
D002945CisplatinCisplatin results in increased expression of CCL23 mRNA27594783
D004041Dietary Fats[Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CCL23 protein25020133
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of CCL23 mRNA"23090859
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of CCL23 mRNA20843944
C088658zoledronic acidzoledronic acid results in increased expression of CCL23 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA10660125  
GO:0008201heparin binding-IEA-  
GO:0031726CCR1 chemokine receptor binding-IPI10660125  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0002548monocyte chemotaxis-IC10660125  
GO:0006874cellular calcium ion homeostasis-TAS9886417  
GO:0006935chemotaxis-TAS9104803  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-TAS9104803  
GO:0007165signal transduction-NAS9886417  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007267cell-cell signaling-TAS9104803  
GO:0008285negative regulation of cell proliferation-TAS9104803  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0048245eosinophil chemotaxis-IBA21873635  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0050729positive regulation of inflammatory response-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO:2001264negative regulation of C-C chemokine binding-IDA10660125  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005623cell-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-444473Formyl peptide receptors bind formyl peptides and many other ligandsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29616282A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells. (2018 Jun)Yi GInflamm Res