Gene: CXCL6

6372
CKA-3|GCP-2|GCP2|SCYB6
C-X-C motif chemokine ligand 6
protein-coding
4q13.3
Ensembl:ENSG00000124875 MIM:138965 Vega:OTTHUMG00000130010 UniprotKB:P80162
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.914e-2 (AD)  1.977e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VGLL30.641
SMR3A0.618
ODAM0.578
LMCD10.563
DEC10.558
FAM47B0.553
MEDAG0.553
AWAT10.546
TNFRSF12A0.541
MTHFD20.532

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC25A45-0.401
KCNQ4-0.398
CHRM1-0.394
SCRT1-0.389
EXTL1-0.38
KCNJ4-0.375
MARCH4-0.373
DLGAP3-0.363
AMER3-0.362
SPRN-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in decreased expression of CXCL6 mRNA19428942
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCL6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCL6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CXCL6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCL6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCL6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CXCL6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CXCL6 mRNA26690555
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of CXCL6 protein]26138014
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CXCL6 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CXCL6 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CXCL6 mRNA24449571
C004984apocarotenalapocarotenal results in increased expression of CXCL6 mRNA17034753
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CXCL6 mRNA"24160326|2575705
D001205Ascorbic AcidAscorbic Acid deficiency results in increased expression of CXCL6 mRNA19932582
D001205Ascorbic AcidAscorbic Acid results in decreased expression of CXCL6 mRNA19932582
D019207beta Carotenebeta Carotene results in increased expression of CXCL6 mRNA17034753
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of CXCL6 mRNA26496021
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of CXCL6 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of CXCL6 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of CXCL6 mRNA28736254
C006780bisphenol Abisphenol A affects the expression of CXCL6 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of CXCL6 mRNA26496021
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of CXCL6 protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in increased expression of and results in increased secretion of CXCL6 protein26138014
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CXCL6 promoter22457795
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCL6 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CXCL6 mRNA26272509
D016572CyclosporineCyclosporine results in decreased expression of CXCL6 mRNA22147139|2798913
D003907DexamethasoneDexamethasone results in decreased expression of CXCL6 mRNA25047013
D004041Dietary FatsDietary Fats results in decreased expression of CXCL6 mRNA21852083
D004317DoxorubicinDoxorubicin results in decreased expression of CXCL6 mRNA16404146
D005419FlavonoidsFlavonoids results in decreased expression of CXCL6 mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of CXCL6 mRNA28937961
C579046GDC-0152GDC-0152 results in increased expression of CXCL6 protein22956632
C031895lead chromatelead chromate results in increased expression of CXCL6 mRNA23584427
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL6 mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCL6 mRNA22235868
C106335macrophage stimulatory lipopeptide 2macrophage stimulatory lipopeptide 2 results in increased expression of CXCL6 mRNA18832182
C106335macrophage stimulatory lipopeptide 2nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL6 mRNA]18832182
D008345ManganeseManganese results in increased expression of CXCL6 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of CXCL6 mRNA17175027
D008610Menthol[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of CXCL6 protein27818348
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CXCL6 mRNA23103053
D009532NickelNickel results in increased expression of CXCL6 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of CXCL6 mRNA17312168
C029938nickel sulfatenickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL6 mRNA]18832182
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CXCL6 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CXCL6 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CXCL6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CXCL6 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of CXCL6 mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of CXCL6 mRNA21297082
C059514resveratrolresveratrol results in decreased expression of CXCL6 mRNA23224687
D019438RitonavirRitonavir results in decreased expression of CXCL626626330
C049705S-1,2-dichlorovinyl-N-acetylcysteine"S-1,2-dichlorovinyl-N-acetylcysteine affects the expression of CXCL6 mRNA"16844155
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of CXCL6 mRNA"24160326
C017947sodium arsenitesodium arsenite results in increased expression of CXCL6 mRNA28595984
D053260SootSoot results in decreased expression of CXCL6 mRNA19428942
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCL6 mRNA15644576
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CXCL6 mRNA16979875
D014028Tobacco Smoke Pollution[Tobacco Smoke Pollution co-treated with Menthol] results in increased expression of and results in increased secretion of CXCL6 protein27818348
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CXCL6 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CXCL6 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of CXCL6 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CXCL6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CXCL6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CXCL6 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of CXCL6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CXCL6 mRNA23179753|2438349
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CXCL6 mRNA16979875
C016837zinc chloridezinc chloride results in decreased expression of CXCL6 mRNA19428942

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA8399143  
GO:0008201heparin binding-IEA-  
GO:0045236CXCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-TAS9164944  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-IBA21873635  
GO:0007165signal transduction-TAS9164944  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007267cell-cell signaling-TAS9164944  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0030593neutrophil chemotaxis-IDA8399143  
GO:0030595leukocyte chemotaxis-IBA21873635  
GO:0042119neutrophil activation-IDA8399143  
GO:0042742defense response to bacterium-IEA-  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IBA21873635  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA8399143  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0071222cellular response to lipopolysaccharide-IBA21873635  
GO:0071222cellular response to lipopolysaccharide-IDA8399143  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25249326Body mass index, physical activity, and serum markers of inflammation, immunity, and insulin resistance. (2014 Dec)Kitahara CMCancer Epidemiol Biomarkers Prev