Gene: CXCL11

6373
H174|I-TAC|IP-9|IP9|SCYB11|SCYB9B|b-R1
C-X-C motif chemokine ligand 11
protein-coding
4q21.1
Ensembl:ENSG00000169248 MIM:604852 Vega:OTTHUMG00000130101 UniprotKB:O14625
NC_000004.12
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.837e-1 (AD)  4.098e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCL100.861
CXCL90.803
IRF10.755
SOCS10.733
BATF20.715
ETV70.666
GBP50.662
HAPLN30.661
TAP10.658
IL320.656

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR17-0.324
NME5-0.309
HRH3-0.303
LRRC56-0.302
TMEM179-0.3
MYADML2-0.299
CRYBA2-0.296
SLC7A4-0.293
BFSP1-0.292
ADAMTSL2-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of CXCL11 mRNA19428942|1987928
C00358522-hydroxycholesterol22-hydroxycholesterol results in increased expression of CXCL11 mRNA19426978
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CXCL11 mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CXCL11 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CXCL11 mRNA]28655636
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CXCL11 mRNA"28351761
C0466933-aminofluoranthene3-aminofluoranthene results in increased expression of CXCL11 mRNA19879285
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CXCL11 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CXCL11 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of CXCL11 mRNA25929836
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CXCL11 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CXCL11 mRNA28351761
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CXCL11 mRNA20713471
D004958EstradiolEstradiol results in increased expression of CXCL11 mRNA15557169
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL11 mRNA]15557169
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of CXCL11 mRNA17404688
D001663BilirubinBilirubin results in increased expression of CXCL11 mRNA20196124
D001710BiotinBiotin results in decreased expression of CXCL11 mRNA15219929
C006780bisphenol Abisphenol A affects the expression of CXCL11 mRNA25181051
D002065BuspironeBuspirone results in increased expression of CXCL11 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of CXCL11 promoter22457795
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of CXCL11 mRNA21224055
D002809Chondroitin SulfatesChondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]25833952
D002809Chondroitin SulfatesChondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein]25833952
C000488cladosporincladosporin results in decreased expression of CXCL11 mRNA19818335
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL11 mRNA23503329
C018021cobaltous chloridecobaltous chloride results in decreased expression of CXCL11 mRNA24386269
D003520CyclophosphamideCyclophosphamide results in increased expression of CXCL11 protein18957084
D003703DemecolcineDemecolcine results in increased expression of CXCL11 mRNA23649840
D003840Deoxycholic AcidDeoxycholic Acid results in increased expression of CXCL11 mRNA21224055
C007262deoxynivalenoldeoxynivalenol results in increased expression of CXCL11 mRNA27757495
C007262deoxynivalenoldeoxynivalenol results in decreased expression of CXCL11 mRNA22968694
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL11 mRNA23503329
D002945Cisplatin[Cisplatin co-treated with TNF protein] results in increased expression of CXCL11 mRNA23103562
D002945CisplatinCisplatin results in increased expression of CXCL11 mRNA22023808
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CXCL11 mRNA18164116
D002117CalcitriolCalcitriol results in decreased expression of CXCL11 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of CXCL11 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CXCL11 mRNA21592394
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of CXCL11 mRNA22497863
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CXCL11 mRNA23649840
C020748ferrous sulfateferrous sulfate results in increased expression of CXCL11 mRNA19428942
D005557FormaldehydeFormaldehyde results in decreased expression of CXCL11 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of CXCL11 mRNA23649840
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL11 mRNA]15557169
C056933fumonisin B1fumonisin B1 results in increased expression of CXCL11 mRNA27757495
C039281furanfuran results in increased methylation of CXCL11 gene22079235
C064925gadodiamidegadodiamide results in increased expression of CXCL11 mRNA20959327
C064925gadodiamidegadodiamide results in increased secretion of CXCL11 protein20959327
D005839GentamicinsGentamicins results in increased expression of CXCL11 mRNA22061828
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of CXCL11 mRNA]17109745
C540383INCB018424INCB018424 inhibits the reaction [IFNB1 protein results in increased expression of CXCL11 mRNA]28365849
C540383INCB018424INCB018424 inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]22941906
C540383INCB018424INCB018424 results in decreased expression of CXCL11 mRNA22941906
C051890irinotecanirinotecan affects the expression of CXCL11 mRNA20097248
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL11 mRNA23503329
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CXCL11 mRNA26752646
D007840LatexLatex analog results in increased expression of CXCL11 mRNA24768652
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL11 mRNA"23090859
C433788lipopolysaccharide, E. coli O26-B6"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL11 mRNA]"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCL11 mRNA19428942
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCL11 mRNA25613284
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CXCL11 mRNA26378955
D008727MethotrexateMethotrexate results in decreased expression of CXCL11 mRNA17400583
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of CXCL11 mRNA25177542
C500085muraglitazarmuraglitazar results in decreased expression of CXCL11 mRNA21515302
D009183MycotoxinsMycotoxins results in decreased expression of CXCL11 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CXCL11 mRNA"26683310
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CXCL11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CXCL11 mRNA"25554681
C015380neoechinulinneoechinulin results in decreased expression of CXCL11 mRNA19818335
D009532NickelNickel results in increased expression of CXCL11 mRNA24768652|2558310
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL11 mRNA23503329
C022838nickel chloride"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL11 mRNA]"23090859
C022838nickel chloridenickel chloride affects the expression of CXCL11 mRNA22110744
C012655nimesulide[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL11 mRNA22561872
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of CXCL11 mRNA22561872
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CXCL11 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of CXCL11 mRNA21893156
D010269ParaquatParaquat results in increased expression of CXCL11 mRNA22230393
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CXCL11 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of CXCL11 mRNA28655636
D052638Particulate MatterParticulate Matter results in decreased expression of CXCL11 mRNA23638009
D010476PerfumePerfume results in increased expression of CXCL11 mRNA24768652
D010656PhenylephrinePhenylephrine results in decreased expression of CXCL11 mRNA18158353
C006253pirinixic acidpirinixic acid results in decreased expression of CXCL11 mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in increased expression of CXCL11 mRNA23608068
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of CXCL11 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of CXCL11 mRNA15557169|1740468
C089730rosiglitazonerosiglitazone results in decreased expression of CXCL11 mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CXCL11 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCL11 mRNA19428942
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCL11 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCL11 mRNA22431001
C017947sodium arsenitesodium arsenite results in increased expression of CXCL11 mRNA21911445
D053260SootSoot results in increased expression of CXCL11 mRNA19428942
D013241SterigmatocystinSterigmatocystin results in decreased expression of CXCL11 mRNA19818335
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CXCL11 mRNA26378955
D016559TacrolimusTacrolimus results in increased expression of CXCL11 mRNA23958496
D013656Taurocholic AcidTaurocholic Acid results in increased expression of CXCL11 mRNA21224055
C501413tesaglitazartesaglitazar results in decreased expression of CXCL11 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CXCL11 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CXCL11 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXCL11 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCL11 mRNA28351761
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXCL11 mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCL11 mRNA21889950
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CXCL11 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CXCL11 mRNA21215274
C009495titanium dioxidetitanium dioxide results in increased expression of CXCL11 mRNA19695317
C009495titanium dioxidetitanium dioxide results in increased expression of CXCL11 mRNA21259345
C402696TMC 120ATMC 120A results in decreased expression of CXCL11 mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CXCL11 mRNA20133372
C479163tofacitinibtofacitinib inhibits the reaction [TNF protein results in increased expression of CXCL11 mRNA]22941906
C479163tofacitinibtofacitinib results in decreased expression of CXCL11 mRNA22941906
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CXCL11 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CXCL11 mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CXCL11 mRNA21893156
D014520UrethaneUrethane results in decreased expression of CXCL11 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of CXCL11 gene29154799
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CXCL11 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CXCL11 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CXCL11 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CXCL11 mRNA23034163
D014750VincristineVincristine results in increased expression of CXCL11 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of CXCL11 mRNA26682919
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL11 mRNA23503329
C016837zinc chloridezinc chloride results in increased expression of CXCL11 mRNA19428942

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18275857  21314817  25416956  
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA12782716  
GO:0008201heparin binding-IMP18645041  
GO:0045236CXCR chemokine receptor binding-IBA21873635  
GO:0048248CXCR3 chemokine receptor binding-IDA12782716  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IDA12782716  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-IBA21873635  
GO:0007165signal transduction-TAS10233762  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007267cell-cell signaling-TAS10233762  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010818T cell chemotaxis-IMP18645041  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0030595leukocyte chemotaxis-IBA21873635  
GO:0042127regulation of cell proliferation-IMP12782716  
GO:0043950positive regulation of cAMP-mediated signaling-IDA12782716  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IDA12782716  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IMP18645041  
GO:0071222cellular response to lipopolysaccharide-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005623cell-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa04620Toll-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24997814Differential expression of the inflammation-associated chemokines/cytokines in mouse lung after exposure to cigarette smoke and smoking cessation. (2014 Jun)Li JRZhongguo Yi Xue Ke Xue Yuan Xue Bao
19629358[Inflammatory cells and their mediators in COPD pathogenesis]. (2009 May-Jun)Costa CHRev Assoc Med Bras (1992)
26781212Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders. (2016 Feb)O'Halloran EBAlcohol
28753646Associations between self-reported diabetes and 78 circulating markers of inflammation, immunity, and metabolism among adults in the United States. (2017)Van Dyke ALPLoS One
19635926Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. (2009 Aug 15)Shaykhiev RJ Immunol
28915241The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases. (2017 Sep)Ahsan MPLoS Genet
27477800Low-grade disease activity in early life precedes childhood asthma and allergy. (2016 Aug)Chawes BLDan Med J