Gene: CX3CL1

6376
ABCD-3|C3Xkine|CXC3|CXC3C|NTN|NTT|SCYD1|fractalkine|neurotactin
C-X3-C motif chemokine ligand 1
protein-coding
16q21
Ensembl:ENSG00000006210 MIM:601880 Vega:OTTHUMG00000133469 UniprotKB:P78423
NC_000016.10
PubMed
0   ANCO-SNPs
CD|ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.885e-2 (AD)  5.553e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNRF10.931
TBC1D250.931
FAM131A0.927
PGBD50.925
SYNGR10.921
MEF2D0.92
CLSTN30.919
MAPT0.918
MADD0.917
PPME10.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.51
PHEX-0.501
CXCR2-0.493
YES1-0.488
RNF135-0.484
REST-0.482
OR4F29-0.478
FCGR3B-0.478
ASB4-0.472
IL18RAP-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of CX3CL1 mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CX3CL1 mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]19132243
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]19132243
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CX3CL1 mRNA"19114083
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CX3CL1 mRNA"17547211
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of CX3CL1 mRNA"20713471
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CX3CL1 mRNA"28351761
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CX3CL1 mRNA"23196670
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CX3CL1 mRNA"19692669
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of CX3CL1 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CX3CL1 mRNA"27188386
C0325384-cresol4-cresol inhibits the reaction [IL1B protein results in increased expression of CX3CL1 protein]16954166
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CX3CL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CX3CL1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of CX3CL1 mRNA17562736
D000082Acetaminophen[MST1R protein mutant form co-treated with Acetaminophen] results in increased expression of CX3CL1 mRNA22575169
D020106AcrylamideAcrylamide results in increased expression of CX3CL1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CX3CL1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CX3CL1 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CX3CL1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of CX3CL1 mRNA17547211
C015001arsenitearsenite results in decreased expression of CX3CL1 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of CX3CL1 mRNA]18929588
D001241AspirinAspirin inhibits the reaction [TNF results in increased expression of CX3CL1 mRNA]19493461
D001241AspirinAspirin inhibits the reaction [TNF results in increased expression of CX3CL1 protein]19493461
D001241AspirinAspirin results in decreased expression of CX3CL1 mRNA19997773
D001241AspirinAspirin results in decreased expression of CX3CL1 protein19997773
C006703benzo(b)fluoranthenebenzo(b)fluoranthene affects the expression of CX3CL1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CX3CL1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CX3CL1 mRNA28351761
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CX3CL1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CX3CL1 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [TNF protein results in increased expression of CX3CL1 mRNA]11698246
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CX3CL1 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of CX3CL1 mRNA21179406
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CX3CL1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CX3CL1 mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of CX3CL1 mRNA19818335
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CX3CL1 mRNA22079614
C584509C646 compoundC646 compound results in increased expression of CX3CL1 mRNA26191083
D002211CapsaicinCapsaicin affects the expression of CX3CL1 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]22150557
D002737ChloropreneChloroprene results in decreased expression of CX3CL1 mRNA23125180
D002857ChromiumChromium results in decreased expression of CX3CL1 mRNA17547211
D002922CiguatoxinsCiguatoxins affects the expression of CX3CL1 mRNA18353800
C000488cladosporincladosporin results in increased expression of CX3CL1 mRNA19818335
D002994ClofibrateClofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]19132243
D002994ClofibrateClofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]19132243
D003035CobaltTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]23503329
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA23503329
D003042CocaineCocaine results in increased expression of CX3CL1 mRNA16076954
D019327Copper SulfateCopper Sulfate results in decreased expression of CX3CL1 mRNA19549813
C038459curdlancurdlan affects the expression of CX3CL1 mRNA19904525
D003520CyclophosphamideCyclophosphamide results in increased expression of CX3CL1 protein16651033
D016572CyclosporineCyclosporine results in decreased expression of CX3CL1 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CX3CL1 mRNA20106945
D013759DronabinolDronabinol results in decreased expression of CX3CL1 mRNA12237329
C007262deoxynivalenoldeoxynivalenol results in increased expression of CX3CL1 mRNA22846391
C007262deoxynivalenoldeoxynivalenol results in increased expression of CX3CL1 mRNA23326479
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of CX3CL1 mRNA22733784
D003907DexamethasoneDexamethasone results in increased expression of CX3CL1 mRNA21041162
D003907DexamethasoneTetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA]16054899
D003907DexamethasoneTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]23503329
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA23503329
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CX3CL1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CX3CL1 mRNA21266533
C121718dicyclanildicyclanil results in increased expression of CX3CL1 mRNA15664270
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CX3CL1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CX3CL1 mRNA23830814
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CX3CL1 mRNA17547211
D004237DiuronDiuron metabolite results in increased expression of CX3CL1 mRNA24172598
D000431EthanolEthanol affects the expression of CX3CL1 mRNA11772933
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CX3CL1 mRNA17555576
D011345FenofibrateFenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]19132243
D011345FenofibrateFenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]19132243
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of CX3CL1 mRNA17187413
C039281furanfuran results in decreased methylation of CX3CL1 gene27387713
C039281furanfuran results in increased expression of CX3CL1 mRNA27387713
D005947Glucose2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]19132243
D005947Glucose2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]19132243
D005947GlucoseClofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]19132243
D005947GlucoseClofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]19132243
D005947GlucoseFenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]19132243
D005947GlucoseFenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]19132243
D005947GlucoseGlucose results in increased expression of CX3CL1 mRNA19132243
D005947GlucoseGlucose results in increased expression of CX3CL1 protein19132243
D005947GlucoseSB 203580 inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]19132243
D005947GlucoseSB 203580 inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]19132243
D017313FenretinideFenretinide results in increased expression of CX3CL1 mRNA28973697
D006861Hydrogen PeroxideCX3CL1 inhibits the reaction [Vehicle Emissions results in increased abundance of Hydrogen Peroxide]21561831
D007052IbuprofenIbuprofen affects the expression of CX3CL1 mRNA17070997
C492448ICG 001ICG 001 results in increased expression of CX3CL1 mRNA26191083
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA]16054899
D0150561-Methyl-3-isobutylxanthineTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]23503329
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA23503329
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CX3CL1 mRNA]26582142
D007649KetamineKetamine results in increased expression of CX3CL1 mRNA20080153
D007854LeadLead affects the expression of CX3CL1 mRNA28903495
C008261lead acetatelead acetate results in increased secretion of CX3CL1 protein17047031
C423914LG 268LG 268 inhibits the reaction [TNF protein results in increased expression of CX3CL1 mRNA]19850645
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CX3CL1 mRNA]26582142
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CX3CL1 mRNA26582142
D008466MechlorethamineMechlorethamine results in increased expression of CX3CL1 mRNA26273949
D008691MethadoneMethadone results in increased secretion of CX3CL1 protein20178837
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CX3CL1 mRNA20713471
D015735MifepristoneMifepristone results in increased expression of CX3CL1 mRNA17584828
D009020MorphineCX3CL1 protein affects the susceptibility to Morphine15317861
D009020MorphineMorphine results in increased secretion of CX3CL1 protein20178837
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of CX3CL1 mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of CX3CL1 mRNA19818335
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CX3CL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CX3CL1 mRNA"25554681
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]22150557
C015380neoechinulinneoechinulin results in decreased expression of CX3CL1 mRNA19818335
C015380neoechinulinneoechinulin results in increased expression of CX3CL1 mRNA19818335
C490266neoechinulin Aneoechinulin A results in increased expression of CX3CL1 mRNA19818335
D009532NickelNickel affects the expression of CX3CL1 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of CX3CL1 mRNA]14575637
D009532NickelTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]23503329
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA23503329
C022838nickel chloridenickel chloride results in increased expression of CX3CL1 mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of CX3CL1 mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of CX3CL1 mRNA17616710
C016340o,p'-DDT"o,p'-DDT results in decreased expression of CX3CL1 mRNA"18204070
D010100OxygenOxygen deficiency results in increased susceptibility to CX3CL1 protein17476338
D010126OzoneOzone results in decreased expression of CX3CL1 mRNA16716893
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CX3CL1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CX3CL1 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of CX3CL1 mRNA19159669
D010672PhenytoinPhenytoin results in increased expression of CX3CL1 mRNA20345932
D010936Plant ExtractsPlant Extracts results in decreased expression of CX3CL1 mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of CX3CL1 mRNA21297082
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CX3CL1 mRNA17547211
D011374ProgesteroneCX3CL1 protein promotes the reaction [CGB3 protein results in increased abundance of Progesterone]18292196
D011374ProgesteroneProgesterone results in decreased expression of CX3CL1 mRNA22238285
C066229prolinedithiocarbamateprolinedithiocarbamate inhibits the reaction [TNF results in increased expression of CX3CL1 mRNA]19493461
D011794QuercetinQuercetin results in decreased expression of CX3CL1 mRNA21632981
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased expression of CX3CL1 mRNA]16614140
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased expression of CX3CL1 protein]16614140
C059514resveratrolresveratrol results in decreased expression of CX3CL1 mRNA23224687
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased expression of CX3CL1 protein]16614140
C116926rofecoxibrofecoxib affects the expression of CX3CL1 mRNA17070997
C089730rosiglitazonerosiglitazone affects the localization of CX3CL1 protein19850645
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA16054899
C089730rosiglitazoneTetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA]16054899
D012431RutinRutin results in decreased expression of CX3CL1 mRNA28693884
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CX3CL1 mRNA21427059
C093642SB 203580SB 203580 inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]19132243
C093642SB 203580SB 203580 inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]19132243
D012822Silicon DioxideSilicon Dioxide results in increased expression of CX3CL1 mRNA22431001
D012834SilverSilver results in increased secretion of CX3CL1 protein26702581
C017947sodium arsenitesodium arsenite results in decreased expression of CX3CL1 mRNA21911445
D013241SterigmatocystinSterigmatocystin results in increased expression of CX3CL1 mRNA19818335
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]22150557
D013629TamoxifenTamoxifen affects the expression of CX3CL1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CX3CL1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CX3CL1 mRNA28351761
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of CX3CL1 mRNA]15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CX3CL1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CX3CL1 mRNA22298810
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of CX3CL1 mRNA19850645
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CX3CL1 mRNA23830814
C009495titanium dioxidetitanium dioxide results in decreased expression of CX3CL1 mRNA27760801
C402696TMC 120ATMC 120A results in increased expression of CX3CL1 mRNA19818335
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CX3CL1 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CX3CL1 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CX3CL1 protein24632068
D014107Tosyllysine Chloromethyl KetoneTosyllysine Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CX3CL1 mRNA]11698246
D014212TretinoinTretinoin results in decreased expression of CX3CL1 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of CX3CL1 mRNA20488242
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of CX3CL1 mRNA]14575637
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CX3CL1 mRNA15973123
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CX3CL1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CX3CL1 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of CX3CL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CX3CL1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of CX3CL1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of CX3CL1 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of CX3CL1 mRNA21427059
D014640VancomycinVancomycin results in decreased expression of CX3CL1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CX3CL1 gene25560391
D001335Vehicle EmissionsCX3CL1 inhibits the reaction [Vehicle Emissions results in increased abundance of Hydrogen Peroxide]21561831
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CX3CL1 protein21561831
D015032ZincTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]23503329
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA23503329
C088658zoledronic acidzoledronic acid results in increased expression of CX3CL1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS12714508  
GO:0005178integrin binding-IDA23125415  
GO:0005515protein binding-IPI9931005  23125415  24789099  25745166  
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA21829356  
GO:0008009chemokine activity-TAS12714508  
GO:0031737CX3C chemokine receptor binding-IDA23125415  
GO:0048020CCR chemokine receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002523leukocyte migration involved in inflammatory response-IMP23125415  
GO:0002548monocyte chemotaxis-IBA21873635  
GO:0006935chemotaxis-IDA21829356  
GO:0006935chemotaxis-IMP23125415  
GO:0006952defense response-TAS12714508  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-TAS12714508  
GO:0007155cell adhesion-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0019221cytokine-mediated signaling pathway-TAS11777952  
GO:0030336negative regulation of cell migration-IDA25435433  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0030595leukocyte chemotaxis-TAS11777952  
GO:0032914positive regulation of transforming growth factor beta1 production-IEA-  
GO:0033622integrin activation-IMP23125415  
GO:0043547positive regulation of GTPase activity-IBA21873635  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0048245eosinophil chemotaxis-IBA21873635  
GO:0048246macrophage chemotaxis-IEA-  
GO:0048247lymphocyte chemotaxis-IBA21873635  
GO:0050729positive regulation of inflammatory response-IEP11777952  
GO:0050902leukocyte adhesive activation-TAS12714508  
GO:0051041positive regulation of calcium-independent cell-cell adhesion-IDA12714508  
GO:0060055angiogenesis involved in wound healing-IEA-  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071346cellular response to interferon-gamma-IBA21873635  
GO:0071347cellular response to interleukin-1-IBA21873635  
GO:0071356cellular response to tumor necrosis factor-IBA21873635  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA12714508  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0009986cell surface-IDA12714508  
GO:0016021integral component of membrane-IDA12714508  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24854157Plasma profile of pro-inflammatory cytokines and chemokines in cocaine users under outpatient treatment: influence of cocaine symptom severity and psychiatric co-morbidity. (2015 Jul)Araos PAddict Biol
19372452Fractalkine receptor/ligand genetic variants and carotid intima-media thickness. (2009 Jun)Debette SStroke
23143793Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium. (2013 Feb)Rius CThorax
29380447Differential impact of CX3CL1 on lung cancer prognosis in smokers and non-smokers. (2018 May)Su YCMol Carcinog
25734326Plasma concentrations of BDNF and IGF-1 in abstinent cocaine users with high prevalence of substance use disorders: relationship to psychiatric comorbidity. (2015)Pedraz MPLoS One