Gene: BIK

638
BIP1|BP4|NBK
BCL2 interacting killer
protein-coding
22q13.2
Ensembl:ENSG00000100290 MIM:603392 Vega:OTTHUMG00000150703 UniprotKB:Q13323
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.459e-1 (AD)  9.912e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04304450chr22:43525431BIK7.800e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL160.464
HIST1H2BD0.431
S100Z0.414
SOWAHD0.401
HIST1H2BO0.4
HIST1H2BJ0.397
HIST1H2BK0.391
ZC3H12D0.389
HIST1H1E0.388
PRRG40.381

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EFHB-0.246
CIB4-0.239
OR6S1-0.239
TMC1-0.2
SERPINA11-0.193
MC3R-0.191
SYT9-0.189
NBPF6-0.189
TAS2R10-0.186
OR7D4-0.182

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased expression of BIK mRNA19435785
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIK mRNA"28903501
C0292162-amino-3-methylimidazo(4,5-f)quinoline"2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of BIK mRNA"26198647
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased expression of BIK mRNA12208782
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of BIK mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BIK mRNA"27188386
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of BIK mRNA27589474
D000082AcetaminophenAcetaminophen results in increased expression of BIK mRNA25704631|2906747
C016601afimoxifeneafimoxifene results in increased expression of BIK mRNA23373633
D016604Aflatoxin B1Aflatoxin B1 affects the expression of BIK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BIK mRNA21641981|2619864
D000447AldehydesAldehydes results in increased expression of BIK mRNA25014914
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of BIK mRNA28070108
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BIK mRNA16483693
D001151ArsenicArsenic affects the expression of BIK protein24675094
C006632arsenic trioxidearsenic trioxide results in increased expression of BIK mRNA24345465
C006632arsenic trioxide[sanguinarine co-treated with arsenic trioxide] results in increased expression of BIK mRNA24345465
C006632arsenic trioxidearsenic trioxide results in increased expression of BIK mRNA19730151
D001374Azacitidine[Azacitidine co-treated with entinostat] results in increased expression of BIK mRNA21224363
D001374AzacitidineAzacitidine results in increased expression of BIK mRNA21224363
C029876benzidinebenzidine results in increased expression of BIK mRNA26198647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BIK mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BIK mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BIK mRNA"19150397
D004958EstradiolEstradiol affects the expression of BIK mRNA21826169
D004958Estradiol[Estradiol co-treated with EGF protein] results in decreased expression of BIK mRNA24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BIK mRNA19619570
D004958EstradiolEstradiol results in decreased expression of BIK mRNA19619570|2337363
D004958EstradiolEstradiol results in increased expression of BIK protein17638070
C006780bisphenol Abisphenol A affects the expression of BIK mRNA21826169
C006780bisphenol Abisphenol A results in decreased expression of BIK mRNA24062438
C006780bisphenol Abisphenol A results in decreased expression of BIK mRNA24066056
C006780bisphenol Abisphenol A results in increased expression of BIK mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of BIK mRNA26198647
D000069286BortezomibBIK results in increased susceptibility to Bortezomib18566236
D000069286BortezomibBortezomib results in increased activity of BIK protein16446371
D000069286BortezomibBortezomib results in increased expression of BIK protein18566236
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of BIK mRNA23410634
C026105butylidenephthalidebutylidenephthalide results in increased expression of BIK protein23770345
C018475butyraldehydebutyraldehyde results in increased expression of BIK mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of BIK mRNA25979313
D002251Carbon Tetrachloride[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BIK mRNA16610055
D002699ChlorambucilChlorambucil results in increased expression of BIK mRNA26198647
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BIK mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of BIK mRNA26272509
D004390ChlorpyrifosBIK gene mutant form results in decreased susceptibility to Chlorpyrifos26299976
D004390ChlorpyrifosChlorpyrifos results in decreased expression of BIK mRNA26299976
D002784CholesterolCholesterol analog results in increased expression of BIK mRNA19477266
D003024ClozapineClozapine results in increased expression of BIK mRNA16160616
D003024ClozapineCSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]16160616
D003042CocaineCocaine affects the expression of BIK mRNA15681117
D019327Copper SulfateCopper Sulfate results in increased expression of BIK mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of BIK mRNA19167446
D003520CyclophosphamideCyclophosphamide results in decreased expression of BIK mRNA17403535
D016572CyclosporineCyclosporine results in increased expression of BIK mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of BIK mRNA23914054
C014347decitabine[decitabine co-treated with Depsipeptides] results in increased expression of BIK mRNA17064661
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of BIK mRNA]21095227
C014347decitabinedecitabine results in increased expression of BIK protein17064661
C014347decitabineDepsipeptides promotes the reaction [decitabine results in increased expression of BIK protein]17064661
D047630Depsipeptides[decitabine co-treated with Depsipeptides] results in increased expression of BIK mRNA17064661
D047630DepsipeptidesDepsipeptides promotes the reaction [decitabine results in increased expression of BIK protein]17064661
D047630DepsipeptidesDepsipeptides results in increased expression of BIK mRNA17064661
D047630DepsipeptidesDepsipeptides results in increased expression of BIK protein17064661
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of BIK mRNA]27941970
D003976DiazinonDiazinon affects the expression of BIK mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BIK mRNA17361019|2126653
D002945CisplatinCisplatin affects the localization of and affects the expression of BIK protein26059411
D002945CisplatinCisplatin results in increased expression of BIK mRNA20878077|2739243
D002945CisplatinY 27632 inhibits the reaction [Cisplatin results in increased expression of BIK mRNA]20878077
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the expression of BIK mRNA24576310
D004026DieldrinDieldrin results in increased expression of BIK mRNA28385952
D004026DieldrinDieldrin affects the expression of BIK mRNA22546817
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BIK mRNA24535843
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of BIK mRNA28939011
D004147DioxinsDioxins affects the expression of BIK mRNA20463971
D004237DiuronDiuron results in increased expression of BIK mRNA25152437
C521792DMU-212DMU-212 results in increased expression of BIK mRNA24055891
D004317DoxorubicinBIK protein results in increased susceptibility to Doxorubicin16007125
D004317DoxorubicinDoxorubicin results in decreased expression of BIK mRNA16705698
C118739entinostatentinostat results in increased expression of BIK mRNA27188386
C118739entinostat[Azacitidine co-treated with entinostat] results in increased expression of BIK mRNA21224363
D000431Ethanol[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BIK mRNA16610055
D005047EtoposideBIK protein results in increased susceptibility to Etoposide16007125
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of BIK mRNA23208426
D005419FlavonoidsFlavonoids results in increased expression of BIK mRNA18035473
D004397FonofosFonofos results in increased methylation of BIK promoter22847954
C039281furanfuran results in decreased expression of BIK mRNA24183702
C039281furanfuran results in increased expression of BIK mRNA20562052|2207923
D005665FurosemideFurosemide affects the expression of BIK mRNA17497460
D017313FenretinideFenretinide results in increased expression of BIK mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of BIK mRNA23410634
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of and affects the expression of BIK protein26059411
D006861Hydrogen PeroxideHydrogen Peroxide affects the localization of BIK protein26059411
D006918HydroxyureaHydroxyurea results in increased expression of BIK mRNA27208086
C045463leflunomideleflunomide results in increased expression of BIK mRNA28988120
D008344ManebManeb results in increased expression of BIK mRNA18266926
D008344ManebManeb results in increased expression of BIK protein18266926
D008344Maneb[Paraquat co-treated with Maneb] results in increased expression of BIK protein18266926
D008727Methotrexate[Methotrexate co-treated with CDKN1A protein] results in decreased expression of BIK mRNA18483502
D008727MethotrexateMethotrexate results in increased expression of BIK mRNA18483502
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of BIK mRNA18266926
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of BIK protein18266926
C500085muraglitazarmuraglitazar results in decreased expression of BIK mRNA21515302
C022838nickel chloridenickel chloride results in decreased expression of BIK mRNA24612858
C022838nickel chloridenickel chloride affects the expression of BIK mRNA22546817
C025589ochratoxin Aochratoxin A results in increased expression of BIK mRNA23208426|2335814
C076029olanzapineolanzapine results in increased expression of BIK mRNA16160616
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of BIK mRNA"22937105
C016340o,p'-DDT"o,p'-DDT results in increased expression of BIK mRNA"22937105
C019248pamidronateBIK protein results in increased susceptibility to pamidronate16007125
D010269Paraquat[Paraquat co-treated with Maneb] results in increased expression of BIK protein18266926
D010269ParaquatParaquat results in increased expression of BIK mRNA18836921
D010278ParathionParathion results in increased methylation of BIK promoter22847954
C046012pentanalpentanal results in increased expression of BIK mRNA26079696
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of BIK mRNA24535843
D010634PhenobarbitalPhenobarbital results in increased expression of BIK mRNA19482888|2309116
C006253pirinixic acidpirinixic acid results in increased expression of BIK mRNA23811191
D010938Plant OilsPlant Oils results in increased expression of BIK mRNA23370395
C045950propiconazolepropiconazole results in decreased expression of BIK mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of BIK mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of BIK mRNA24780913
C031280pyrazole[Ethanol co-treated with pyrazole co-treated with Carbon Tetrachloride] results in increased expression of BIK mRNA16610055
D011794QuercetinQuercetin results in increased expression of BIK mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of BIK mRNA19167446
C089730rosiglitazonerosiglitazone results in decreased expression of BIK mRNA21515302
C005705sanguinarine[sanguinarine co-treated with arsenic trioxide] results in increased expression of BIK mRNA24345465
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of BIK mRNA23806026|2589566
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of BIK mRNA]21095227
D012906SmokeSmoke results in decreased expression of BIK mRNA21095227
D018038Sodium SeleniteSodium Selenite results in decreased expression of BIK mRNA18175754
D013629TamoxifenESR2 protein promotes the reaction [Tamoxifen results in increased expression of BIK protein]17638070
C012568terbufosterbufos results in increased methylation of BIK promoter22847954
C501413tesaglitazartesaglitazar results in decreased expression of BIK mRNA21515302
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BIK mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BIK mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BIK mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BIK mRNA14718646
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BIK mRNA19520675
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of BIK mRNA26198647
C009495titanium dioxidetitanium dioxide results in decreased expression of BIK mRNA23409001
C012589trichostatin Atrichostatin A results in increased expression of BIK mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of BIK mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of BIK mRNA28973697
C057693troglitazonetroglitazone results in decreased expression of BIK mRNA21515302
D014520UrethaneUrethane results in increased expression of BIK mRNA28818685
D014520UrethaneUrethane results in increased expression of BIK mRNA16978161
D014635Valproic AcidValproic Acid affects the expression of BIK mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of BIK mRNA23179753|2493525
D024483Vitamin K 3Vitamin K 3 results in increased expression of BIK mRNA23410634
C108830Y 27632Y 27632 inhibits the reaction [Cisplatin results in increased expression of BIK mRNA]20878077
C108830Y 27632Y 27632 results in decreased expression of BIK mRNA20878077
D015032ZincZinc deficiency results in increased expression of BIK mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9027312  9463381  15694340  16189514  16697956  17289999  
18953687  20010695  21516116  23235460  25416956  26871637  
27107012  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-TAS10381623  
GO:0008584male gonad development-IBA21873635  
GO:0008637apoptotic mitochondrial changes-IBA21873635  
GO:0032464positive regulation of protein homooligomerization-IDA21041309  
GO:0090200positive regulation of release of cytochrome c from mitochondria-IDA21041309  
GO ID GO Term Qualifier Evidence PubMed
GO:0012505endomembrane system-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031966mitochondrial membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26361040HIF-1alpha Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. (2015)Singh SPPLoS One