Gene: SRR

63826
ILV1|ISO1
serine racemase
protein-coding
17p13.3
Ensembl:ENSG00000167720 MIM:606477 Vega:OTTHUMG00000090583 UniprotKB:Q9GZT4
NC_000017.11
PubMed
0   ANCO-SNPs
ND|AD
3   
8.380e-1 (AD)  4.521e-1 (ND)   (Frontal_Cortex)
7.723e-1 (AD)  3.567e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM2310.762
SDHC0.757
MED290.756
IVD0.755
PAICS0.747
ADH50.747
PEX190.745
TK20.743
PDE6D0.743
BBS40.741

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.544
OR4F29-0.495
PPBP-0.329
KLRK1-0.278
LBX2-0.274
FMO3-0.274
OR6C74-0.265
FCER2-0.248
SERPINC1-0.245
KRT38-0.243

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00133SerineSmall Molecule56-45-1Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of SRR mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of SRR mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SRR mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SRR mRNA]17585979
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SRR mRNA19770486
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SRR promoter23359474
C006780bisphenol Abisphenol A results in increased expression of SRR mRNA25181051
D002104CadmiumCadmium results in increased expression of SRR mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SRR mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SRR mRNA17484886
C026690cerous chloridecerous chloride results in increased expression of SRR mRNA23573234
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SRR mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SRR mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SRR mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of SRR mRNA22300585
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SRR mRNA19167446
D003513CycloheximideCycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
D003513CycloheximideCycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
D016572CyclosporineCyclosporine results in increased expression of SRR mRNA27989131
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SRR promoter23359474
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SRR promoter23359474
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SRR mRNA25380136
D004533Egtazic Acid[methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein24012499
D004533Egtazic Acid[methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein24012499
D000431EthanolEthanol results in increased expression of SRR mRNA20655511
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SRR mRNA23649840
D005492Folic AcidFolic Acid results in increased expression of SRR mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SRR mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SRR mRNA23649840
D005839GentamicinsGentamicins results in increased expression of SRR mRNA22061828
D005897GlafenineGlafenine results in decreased expression of SRR mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRR mRNA25613284
C008261lead acetatelead acetate results in decreased expression of SRR mRNA25242007
C008261lead acetatelead acetate results in decreased expression of SRR protein25242007
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SRR mRNA20938992
D008727MethotrexateMethotrexate affects the expression of SRR mRNA18502557
D008731MethoxychlorMethoxychlor results in increased methylation of SRR gene23303685
C054634methyllycaconitine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitineAKT1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitineCycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitineMAPK1 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitineMAPK3 mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitine[methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein24012499
C054634methyllycaconitinemethyllycaconitine results in increased expression of SRR protein24012499
C054634methyllycaconitineMTOR mutant form inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitineSirolimus inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitineU 0126 inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitineCycloheximide inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C054634methyllycaconitine[methyllycaconitine co-treated with Egtazic Acid] results in increased expression of SRR protein24012499
C054634methyllycaconitinemethyllycaconitine results in increased expression of SRR protein24012499
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SRR mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SRR mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SRR mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of SRR promoter"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SRR mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SRR mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SRR mRNA25380136
C051752nefazodonenefazodone results in decreased expression of SRR mRNA24136188
D009532NickelNickel results in increased expression of SRR mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of SRR mRNA22714537
C012655nimesulidenimesulide results in decreased expression of SRR mRNA24136188
C033419norketaminenorketamine analog results in increased expression of SRR protein24012499
C033419norketaminenorketamine analog results in increased expression of SRR protein24012499
C006253pirinixic acidpirinixic acid results in increased expression of SRR mRNA17426115|1830175
C045950propiconazolepropiconazole results in increased expression of SRR mRNA21278054
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SRR mRNA19167446
D020123SirolimusSirolimus inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
C017947sodium arsenitesodium arsenite results in increased expression of SRR mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRR mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRR mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRR mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRR mRNA25613284
D013806TheophyllineTheophylline results in decreased expression of SRR mRNA18951874
C113580U 0126U 0126 inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]24012499
D014520UrethaneUrethane results in decreased expression of SRR mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SRR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SRR mRNA19101580|2915479
D014640VancomycinVancomycin results in increased expression of SRR mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SRR gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SRR mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA20106978  
GO:0003941L-serine ammonia-lyase activity-IBA21873635  
GO:0003941L-serine ammonia-lyase activity-IDA18812225  
GO:0005509calcium ion binding-ISS-  
GO:0005524ATP binding-IDA20106978  
GO:0005524ATP binding-ISS-  
GO:0008721D-serine ammonia-lyase activity-IBA21873635  
GO:0008721D-serine ammonia-lyase activity-TAS-  
GO:0016594glycine binding-ISS-  
GO:0018114threonine racemase activity-ISS-  
GO:0030165PDZ domain binding-IPI16314870  
GO:0030170pyridoxal phosphate binding-IDA20106978  
GO:0030170pyridoxal phosphate binding-ISS-  
GO:0030378serine racemase activity-IBA21873635  
GO:0030378serine racemase activity-IDA11054547  15193426  20106978  
GO:0030378serine racemase activity-TAS-  
GO:0042803protein homodimerization activity-IDA15681805  
GO:0042803protein homodimerization activity-IPI20106978  
GO ID GO Term Qualifier Evidence PubMed
GO:0006563L-serine metabolic process-IBA21873635  
GO:0006563L-serine metabolic process-IDA11054547  15193426  20106978  
GO:0006564L-serine biosynthetic process-TAS-  
GO:0007420brain development-IBA21873635  
GO:0007420brain development-IEA-  
GO:0007568aging-IEA-  
GO:0009069serine family amino acid metabolic process-ISS-  
GO:0032496response to lipopolysaccharide-IEP15681805  
GO:0042866pyruvate biosynthetic process-IDA18812225  
GO:0043278response to morphine-IEA-  
GO:0051289protein homotetramerization-ISS-  
GO:0070178D-serine metabolic process-IDA20106978  
GO:0070179D-serine biosynthetic process-IBA21873635  
GO:0070179D-serine biosynthetic process-IDA11054547  15193426  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA16314870  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0043025neuronal cell body-IBA21873635  
GO:0043025neuronal cell body-IDA17880399  
GO:0045177apical part of cell-IEA-  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70614Amino acid synthesis and interconversion (transamination)TAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-977347Serine biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25743187Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence. (2015 Mar 2)Pickering CPharmacol Biochem Behav
24722538Meta-analysis of prospective cohort studies of cigarette smoking and the incidence of colon and rectal cancers. (2015 Jan)Cheng JEur J Cancer Prev
29476432Cigarette smoking and risk of albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis of observational studies. (2018 May)Xu HInt Urol Nephrol