Gene: BCAN

63827
BEHAB|CSPG7
brevican
protein-coding
1q23.1
Ensembl:ENSG00000132692 MIM:600347 Vega:OTTHUMG00000033322 UniprotKB:Q96GW7
NG_030013.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.780e-1 (AD)  2.982e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25773262chr1:156616855BCAN8.800e-12Smoking27651444
cg16269733chr1:156616804BCAN5.700e-10Smoking27651444
cg09182138chr1:156612436BCAN3.600e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNTA10.865
TTYH10.843
EMID10.831
OLFM20.829
ALDH20.827
HTRA10.826
NDRG20.824
MTSS1L0.823
VEGFB0.817
MT30.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.709
OR4F29-0.673
CD163L1-0.295
PTGS2-0.257
GSDMA-0.254
CDCP1-0.254
GADL1-0.251
FER1L6-0.249
FAM20A-0.248
PLA2G4A-0.24

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of BCAN mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BCAN mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCAN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCAN mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of BCAN mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of BCAN mRNA16483693
C015001arsenitearsenite results in increased methylation of BCAN promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of BCAN mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BCAN mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BCAN mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of BCAN mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of BCAN mRNA25181051
D002211CapsaicinCapsaicin results in decreased expression of BCAN mRNA16278290
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of BCAN mRNA27188386
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAN gene20938992
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of BCAN mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of BCAN mRNA26577399
C014347decitabinedecitabine affects the expression of BCAN mRNA23300844
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of BCAN mRNA]27941970
D002945CisplatinCisplatin affects the expression of BCAN mRNA23300844
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAN gene20938992
D005839GentamicinsGentamicins results in decreased expression of BCAN mRNA22061828
D007657Ketone BodiesKetone Bodies results in decreased expression of BCAN mRNA16807920
D007854LeadLead affects the expression of BCAN mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCAN gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BCAN mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of BCAN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BCAN mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of BCAN mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of BCAN mRNA20971185
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCAN mRNA"27188386
D010936Plant ExtractsPlant Extracts results in decreased expression of BCAN mRNA23557933
D011441PropylthiouracilPropylthiouracil affects the expression of BCAN mRNA24780913
D053260SootSoot results in decreased expression of BCAN mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCAN mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCAN mRNA22298810
C009495titanium dioxidetitanium dioxide results in increased expression of BCAN mRNA19695317
C009495titanium dioxidetitanium dioxide results in decreased expression of BCAN mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of BCAN mRNA20133372
D014212TretinoinTretinoin results in decreased expression of BCAN mRNA20530235
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of BCAN mRNA19042947
D014520UrethaneUrethane results in decreased expression of BCAN mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of BCAN mRNA23179753|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IBA21873635  
GO:0007155cell adhesion-IEA-  
GO:0007417central nervous system development-IBA21873635  
GO:0021766hippocampus development-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030206chondroitin sulfate biosynthetic process-TAS-  
GO:0030207chondroitin sulfate catabolic process-TAS-  
GO:0030208dermatan sulfate biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0031225anchored component of membrane-IEA-  
GO:0043202lysosomal lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-1971475A tetrasaccharide linker sequence is required for GAG synthesisTAS
R-HSA-2022870Chondroitin sulfate biosynthesisTAS
R-HSA-2022923Dermatan sulfate biosynthesisTAS
R-HSA-2024101CS/DS degradationTAS
R-HSA-3000178ECM proteoglycansTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3560783Defective B4GALT7 causes EDS, progeroid typeTAS
R-HSA-3560801Defective B3GAT3 causes JDSSDHDTAS
R-HSA-3595172Defective CHST3 causes SEDCJDTAS
R-HSA-3595174Defective CHST14 causes EDS, musculocontractural typeTAS
R-HSA-3595177Defective CHSY1 causes TPBSTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-4420332Defective B3GALT6 causes EDSP2 and SEMDJL1TAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20439032BCAN Think Tank session 1: Overview of risks for and causes of bladder cancer. (2010 May-Jun)Zlotta ARUrol Oncol
20439034BCAN Think Tank session 3: Prevention of bladder cancer. (2010 May-Jun)Lerner SPUrol Oncol