Gene: SDC4

6385
SYND4
syndecan 4
protein-coding
20q13.12
Ensembl:ENSG00000124145 MIM:600017 Vega:OTTHUMG00000033083 UniprotKB:P31431
NC_000020.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.310e-2 (AD)  2.127e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPON10.9
ETNPPL0.894
PBXIP10.888
AGT0.886
METTL7A0.878
NTSR20.872
FGFR30.871
SOX90.87
NTRK20.868
ZNRF30.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TC2N-0.468
LGI2-0.445
SCARA5-0.439
PAQR9-0.412
ADCY7-0.411
TRIM58-0.41
CCDC68-0.402
GPR85-0.4
PLS1-0.398
TDRD1-0.396

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SDC4 mRNA"21354444
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SDC4 mRNA"25614096
C499807(2R, 3S)-2-(((4-(2-butynyloxy)phenyl)sulfonyl)amino)-N,3-dihydroxybutanamide"(2R, 3S)-2-(((4-(2-butynyloxy)phenyl)sulfonyl)amino)-N,3-dihydroxybutanamide results in decreased secretion of SDC4 protein"19875451
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SDC4 mRNA16788091
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of SDC4 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SDC4 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of SDC4 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of SDC4 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SDC4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SDC4 mRNA]17585979
D000086AcetazolamideAcetazolamide results in increased expression of SDC4 mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SDC4 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of SDC4 mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SDC4 mRNA16483693
C484302apratastatapratastat results in decreased secretion of SDC4 protein19875451
D001104ArbutinArbutin results in decreased expression of SDC4 mRNA17103032
C006632arsenic trioxidearsenic trioxide results in decreased expression of SDC4 mRNA15761015
D001241AspirinAspirin results in decreased expression of SDC4 mRNA15928584
D001280AtrazineAtrazine results in increased expression of SDC4 mRNA25929836
D001280AtrazineAtrazine results in increased expression of SDC4 mRNA18585445|2237831
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SDC4 mRNA"19150397
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of SDC4 mRNA20404318
D004958EstradiolEstradiol results in decreased expression of SDC4 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SDC4 mRNA28628672
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of SDC4 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of SDC4 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SDC4 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SDC4 mRNA25181051
C025703bleomycetinbleomycetin results in increased expression of SDC4 mRNA21040473
D002065BuspironeBuspirone results in increased expression of SDC4 mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of SDC4 mRNA26079696
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of SDC4 mRNA20360939
D000074262Canola OilCanola Oil metabolite results in decreased expression of SDC4 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SDC4 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SDC4 mRNA17056239
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SDC4 mRNA20938992
C418118CI 1044CI 1044 results in increased expression of SDC4 mRNA17569694
D002922CiguatoxinsCiguatoxins affects the expression of SDC4 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SDC4 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of SDC4 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SDC4 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of SDC4 mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of SDC4 mRNA15755911
D003471CuprizoneCuprizone results in increased expression of SDC4 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of SDC4 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of SDC4 mRNA21198554
C014347decitabinedecitabine results in increased expression of SDC4 mRNA19151715
D013759DronabinolDronabinol results in increased expression of SDC4 mRNA21955143
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SDC4 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of SDC4 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of SDC4 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SDC4 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SDC4 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SDC4 mRNA28962523
D002945CisplatinCisplatin results in increased expression of SDC4 mRNA24280081|2739243
D002945CisplatinCisplatin results in increased expression of SDC4 mRNA24280081
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of SDC4 mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of SDC4 mRNA"21785161
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SDC4 mRNA20064776
D000431EthanolEthanol results in increased expression of SDC4 mRNA21955143
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SDC4 mRNA17108234
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SDC4 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of SDC4 mRNA19167457
C039281furanfuran results in increased expression of SDC4 mRNA26194646
D005897GlafenineGlafenine results in increased expression of SDC4 mRNA24136188
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of SDC4 mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of SDC4 mRNA17109745
D005944GlucosamineIL1B inhibits the reaction [Glucosamine results in decreased expression of SDC4 mRNA]17109745
C010974glyphosateglyphosate results in increased expression of SDC4 mRNA25636363
C492546GW280264XGW280264X inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of SDC4 protein]19875451
C492546GW280264XGW280264X inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SDC4 protein]19875451
C492546GW280264XGW280264X results in decreased secretion of and results in decreased cleavage of SDC4 protein19875451
C492546GW280264XGW280264X results in increased expression of SDC4 protein alternative form19875451
C492546GW280264XGW280264X inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of SDC4 protein]19875451
C492546GW280264XGW280264X results in decreased secretion of SDC4 protein19875451
D006493HeparinHeparin analog results in increased expression of SDC4 mRNA26476401
D017313FenretinideFenretinide results in increased expression of SDC4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SDC418687144
D002112CalcifediolCalcifediol deficiency results in increased expression of SDC4 mRNA17293106
C503753Indolinone AIndolinone A results in increased expression of SDC4 mRNA15712243
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SDC4 mRNA28628672
C051890irinotecanirinotecan metabolite results in increased expression of SDC4 mRNA15956246
C051890irinotecanirinotecan results in increased expression of SDC4 mRNA15956246
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SDC4 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SDC4 mRNA24796395
C410337K 7174K 7174 results in increased expression of SDC4 mRNA24086573
C011890kojic acidkojic acid results in decreased expression of SDC4 mRNA16595896
D007854LeadLead results in decreased expression of SDC4 mRNA19921347
C045463leflunomideleflunomide results in increased expression of SDC4 mRNA28988120
D064704LevofloxacinLevofloxacin results in increased expression of SDC4 mRNA24136188
D001556LindaneLindane results in increased expression of SDC4 mRNA17785943
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SDC4 mRNA21641980
D008627Mercuric ChlorideMercuric Chloride affects the expression of SDC4 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SDC4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SDC4 mRNA23179753
D009020MorphineMorphine results in increased expression of SDC4 mRNA21955143
C092152N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of SDC4 protein]"19875451
C092152N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SDC4 protein]"19875451
C092152N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide results in decreased secretion of SDC4 protein"19875451
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SDC4 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of SDC4 mRNA19812364
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SDC4 mRNA19812364
D009532NickelNickel results in increased expression of SDC4 mRNA23195993
C022838nickel chloridenickel chloride results in increased expression of SDC4 mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of SDC4 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of SDC4 mRNA18651567
D009538NicotineNicotine results in increased expression of SDC4 mRNA21955143
D005996NitroglycerinNitroglycerin results in decreased expression of SDC4 mRNA12102619
D000069463Olive OilOlive Oil analog affects the expression of SDC4 mRNA17349074
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in increased expression of SDC4 mRNA"16823509
D043371Fatty Acids, Omega-6"Fatty Acids, Omega-6 results in increased expression of SDC4 mRNA"16823509
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SDC4 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SDC4 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SDC4 mRNA26272509
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SDC4 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of SDC4 mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SDC4 mRNA16221955
D010634PhenobarbitalPhenobarbital affects the expression of SDC4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of SDC4 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SDC4 mRNA26272509
D010672PhenytoinPhenytoin results in decreased expression of SDC4 mRNA15136057
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SDC4 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of SDC4 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of SDC4 mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in increased expression of SDC4 mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of SDC4 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SDC4 mRNA22698814|2890350
D011374ProgesteroneProgesterone results in decreased expression of SDC4 mRNA20864642
C045950propiconazolepropiconazole results in decreased expression of SDC4 mRNA21278054
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SDC4 mRNA27029645
D011794QuercetinQuercetin results in increased expression of SDC4 mRNA21632981
C009250sevofluranesevoflurane affects the expression of SDC4 mRNA15967596
D012822Silicon DioxideSilicon Dioxide results in increased expression of SDC4 mRNA19073995
D019821SimvastatinSimvastatin results in decreased expression of SDC4 mRNA16414398
C009277sodium arsenatesodium arsenate results in increased expression of SDC4 mRNA23922661
C009277sodium arsenatesodium arsenate results in decreased expression of SDC4 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of SDC4 mRNA21795629
D012999SomanSoman results in increased expression of SDC4 mRNA19281266
D053260SootSoot results in increased expression of SDC4 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SDC4 mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of SDC4 mRNA"26680231
D013739TestosteroneTestosterone results in increased expression of SDC4 mRNA21669218
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of SDC4 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SDC4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SDC4 mRNA19770486
D013755Tetradecanoylphorbol AcetateGW280264X inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SDC4 protein]19875451
D013755Tetradecanoylphorbol Acetate"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of SDC4 protein]"19875451
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of and results in increased cleavage of and results in increased secretion of SDC4 protein19875451
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of SDC4 protein alternative form19875451
C009495titanium dioxidetitanium dioxide results in increased expression of SDC4 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SDC4 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SDC4 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of SDC4 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SDC4 mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SDC4 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SDC4 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SDC4 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SDC4 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SDC4 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of SDC4 mRNA28973697
D014520UrethaneUrethane results in increased expression of SDC4 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of SDC4 mRNA23527032|2800136
C025643vinclozolinvinclozolin affects the expression of SDC4 mRNA23034163
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SDC4 mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of SDC4 mRNA24714768
C088658zoledronic acidzoledronic acid results in increased expression of SDC4 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001968fibronectin binding-IEA-  
GO:0005080protein kinase C binding-IEA-  
GO:0005515protein binding-IPI12571249  18093920  19350579  25416956  
GO:0042802identical protein binding-IPI18093920  
GO:0070053thrombospondin receptor activity-IMP17879962  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0001657ureteric bud development-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0006024glycosaminoglycan biosynthetic process-TAS-  
GO:0006027glycosaminoglycan catabolic process-TAS-  
GO:0007165signal transduction-IEA-  
GO:0010762regulation of fibroblast migration-IEA-  
GO:0016477cell migration-IBA21873635  
GO:0042060wound healing-IEA-  
GO:0042130negative regulation of T cell proliferation-IMP19350579  
GO:0045860positive regulation of protein kinase activity-IEA-  
GO:0050900leukocyte migration-TAS-  
GO:0051496positive regulation of stress fiber assembly-IEA-  
GO:0051894positive regulation of focal adhesion assembly-IEA-  
GO:0060122inner ear receptor cell stereocilium organization-IEA-  
GO:1903543positive regulation of exosomal secretion-IMP22660413  
GO:1903553positive regulation of extracellular exosome assembly-IMP22660413  
GO ID GO Term Qualifier Evidence PubMed
GO:0005796Golgi lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS1500433  
GO:0005925focal adhesion-IEA-  
GO:0009986cell surface-IBA21873635  
GO:0043034costamere-IEA-  
GO:0043202lysosomal lumen-TAS-  
GO:0045121membrane raft-IEA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa04512ECM-receptor interaction
hsa04514Cell adhesion molecules (CAMs)
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismIEA
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismIEA
R-HSA-1643685DiseaseTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-1971475A tetrasaccharide linker sequence is required for GAG synthesisTAS
R-HSA-2022928HS-GAG biosynthesisTAS
R-HSA-2022928HS-GAG biosynthesisIEA
R-HSA-2024096HS-GAG degradationTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-3000170Syndecan interactionsIEA
R-HSA-3000170Syndecan interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3560783Defective B4GALT7 causes EDS, progeroid typeTAS
R-HSA-3560801Defective B3GAT3 causes JDSSDHDTAS
R-HSA-3656237Defective EXT2 causes exostoses 2TAS
R-HSA-3656253Defective EXT1 causes exostoses 1, TRPS2 and CHDSTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-4420332Defective B3GALT6 causes EDSP2 and SEMDJL1TAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-71387Metabolism of carbohydratesIEA
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25567305[Detection of ROS1 gene rearrangement by FISH and analysis of its clinical features in non-small cell lung cancer patients]. (2014 Oct)Cheng HZhonghua Zhong Liu Za Zhi
27994470Identification of feature genes for smoking-related lung adenocarcinoma based on gene expression profile data. (2016)Liu YOnco Targets Ther