Gene: SDHA

6389
CMD1GG|FP|PGL5|SDH1|SDH2|SDHF
succinate dehydrogenase complex flavoprotein subunit A
protein-coding
5p15.33
Ensembl:ENSG00000073578 MIM:600857 Vega:OTTHUMG00000090275 UniprotKB:P31040
NG_012339.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.103e-1 (AD)  8.201e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06060868chr5:231934SDHA1.800e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDUFV10.956
IDH3B0.955
UQCRC10.954
PDHA10.95
UQCRC20.949
DCTN20.946
NDUFS20.945
ACTR1A0.943
PKM0.941
AARS0.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.745
OR4F29-0.712
MTRNR2L6-0.408
MTRNR2L9-0.382
MTRNR2L10-0.369
KCNJ15-0.351
PABPC4L-0.346
KLRB1-0.344
SIX1-0.344
TFPI2-0.343

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of SDHA mRNA"21856379
C0447551-methyl-4-phenyl-2,3-dihydropyridinium"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of SDHA protein"21856379
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of SDHA protein"21673325
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SDHA mRNA"21346803
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in decreased expression of SDHA mRNA"11227219
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SDHA mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in increased oxidation of SDHA protein25716674
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in decreased acetylation of SDHA protein]"24178296
C5294318-2 fluorotelomer alcohol8-2 fluorotelomer alcohol results in increased expression of SDHA mRNA21984479
D000082AcetaminophenAcetaminophen results in decreased expression of SDHA mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of SDHA protein21329376
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of SDHA protein25499718
D000496AlloxanAlloxan results in decreased expression of SDHA protein28483572
D000496Alloxanimisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SDHA protein]28483572
D000517alpha-Chlorohydrinalpha-Chlorohydrin affects the expression of SDHA protein27732882
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SDHA mRNA27732882
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SDHA protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SDHA mRNA16483693
D001151ArsenicArsenic results in increased expression of SDHA protein21514422
C006632arsenic trioxidearsenic trioxide results in increased expression of SDHA protein25419056
C006632arsenic trioxidearsenic trioxide results in decreased expression of SDHA mRNA19422848|2483196
C006632arsenic trioxidearsenic trioxide results in decreased expression of SDHA protein19422848
C006632arsenic trioxidearsenic trioxide results in increased expression of SDHA mRNA19422848
C006632arsenic trioxideAscorbic Acid inhibits the reaction [arsenic trioxide results in decreased expression of SDHA protein]19422848
C006632arsenic trioxideTaurine inhibits the reaction [arsenic trioxide results in decreased expression of SDHA protein]19422848
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [arsenic trioxide results in decreased expression of SDHA protein]19422848
D001280AtrazineAtrazine results in decreased expression of SDHA mRNA27114639
D001280AtrazineAtrazine results in increased expression of SDHA mRNA22378314
D001280AtrazineAtrazine results in increased expression of SDHA mRNA22982499
D001280AtrazineAtrazine affects the expression of SDHA mRNA27114639
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in decreased expression of SDHA protein modified form24464499
D004958EstradiolEstradiol results in increased expression of SDHA mRNA17823450|1870914
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SDHA mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SDHA mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SDHA mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SDHA mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SDHA mRNA28628672
C017092bromopyruvatebromopyruvate results in decreased expression of SDHA mRNA28433571
D002104CadmiumCadmium results in increased expression of SDHA mRNA23256528
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SDHA protein21136600
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SDHA promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SDHA mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SDHA mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of SDHA protein22886373
D002995Clofibric AcidClofibric Acid affects the expression of SDHA mRNA17602206
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SDHA mRNA20971185
D003300CopperCopper results in decreased expression of SDHA mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of SDHA mRNA19549813
D003474CurcuminCurcumin results in decreased expression of SDHA mRNA17198877
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of SDHA mRNA18709148
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SDHA mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SDHA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SDHA mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SDHA mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of SDHA mRNA27392435
D004000DichloroethylenesDichloroethylenes results in increased expression of SDHA mRNA14565619
D004041Dietary FatsDietary Fats results in decreased expression of SDHA protein26655953
D004041Dietary FatsDietary Fats results in increased expression of SDHA mRNA19030233
D004041Dietary Fatsobeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of SDHA protein]26655953
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of SDHA mRNA]"23626681
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SDHA mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SDHA protein23301498
D005419FlavonoidsFlavonoids results in increased expression of SDHA mRNA18035473
D005472FluorouracilSDHA protein affects the susceptibility to Fluorouracil15548681
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SDHA mRNA20938992
D019833GenisteinGenistein results in decreased expression of SDHA mRNA24967385
D005839GentamicinsGentamicins results in increased expression of SDHA mRNA22061828
C121876imisopasem manganeseimisopasem manganese inhibits the reaction [Alloxan results in decreased expression of SDHA protein]28483572
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SDHA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SDHA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SDHA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SDHA mRNA28628672
D007538IsoniazidIsoniazid affects the expression of SDHA mRNA24848797
C410337K 7174K 7174 results in decreased expression of SDHA mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of SDHA mRNA16807920
C008261lead acetatelead acetate results in increased expression of SDHA mRNA21891863
C052901lemongrass oillemongrass oil affects the expression of SDHA mRNA25976427
C025340manganese chloridemanganese chloride results in decreased expression of SDHA mRNA22281203
D008627Mercuric ChlorideMercuric Chloride results in increased expression of SDHA mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SDHA mRNA20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SDHA mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SDHA mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SDHA mRNA23649840
D008743Methyl ParathionMethyl Parathion results in increased expression of SDHA mRNA22182705
D008743Methyl ParathionMethyl Parathion results in increased expression of SDHA protein22182705
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of SDHA mRNA]12710931
D009020MorphineMorphine deficiency affects the reaction [Morphine results in increased expression of SDHA protein]23056601
D009020MorphineMorphine results in increased expression of SDHA protein23056601
C510788N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine"N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine results in increased expression of SDHA protein"25487280
C031721naphthalenenaphthalene results in decreased expression of SDHA protein19438287
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of SDHA protein19716841
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SDHA mRNA20971185
C464660obeticholic acidobeticholic acid inhibits the reaction [Dietary Fats results in decreased expression of SDHA protein]26655953
C025589ochratoxin ABNIP3L protein inhibits the reaction [ochratoxin A results in decreased expression of SDHA mRNA]24755393
C025589ochratoxin ABNIP3L protein inhibits the reaction [ochratoxin A results in decreased expression of SDHA protein]24755393
C025589ochratoxin Aochratoxin A results in decreased expression of SDHA mRNA24755393
C025589ochratoxin Aochratoxin A results in decreased expression of SDHA protein24755393
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of SDHA mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of SDHA mRNA21984479
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SDHA mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SDHA mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SDHA protein23427857
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of SDHA mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SDHA mRNA23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SDHA mRNA18709148
D010695PhlorhizinPhlorhizin results in decreased expression of SDHA mRNA22538082
D045542PQQ CofactorPQQ Cofactor results in increased expression of SDHA protein28578007
C045950propiconazolepropiconazole results in increased metabolism of SDHA protein19714882
C015586propiverinepropiverine binds to SDHA protein29273565
C010313pseudocumenepseudocumene results in decreased expression of SDHA protein17337753
D011748PyrogallolPyrogallol results in increased expression of SDHA mRNA20362636
D011794QuercetinQuercetin results in decreased expression of SDHA protein19207037
C059514resveratrol"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in decreased acetylation of SDHA protein]"24178296
C059514resveratrolresveratrol results in decreased acetylation of SDHA protein24178296
C059514resveratrolresveratrol results in increased expression of SDHA protein24365713
C089730rosiglitazone[rosiglitazone co-treated with Rotenone] results in increased expression of SDHA protein24374061
C089730rosiglitazonerosiglitazone results in increased expression of SDHA protein24374061
C089730rosiglitazonerosiglitazone affects the expression of SDHA mRNA22013433
D012402Rotenone[rosiglitazone co-treated with Rotenone] results in increased expression of SDHA protein24374061
D012906SmokeSmoke results in increased metabolism of SDHA protein19133281
C009277sodium arsenatesodium arsenate results in increased expression of SDHA mRNA16882884
C009277sodium arsenatesodium arsenate results in increased expression of SDHA mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of SDHA mRNA27862939
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in decreased expression of SDHA protein modified form24464499
D013311StreptozocinStreptozocin results in increased expression of SDHA protein19634143|2113669
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of SDHA protein]19634143|2113669
D013654TaurineTaurine inhibits the reaction [arsenic trioxide results in decreased expression of SDHA protein]19422848
D019284ThapsigarginThapsigargin results in decreased expression of SDHA mRNA22378314
D013853ThioacetamideThioacetamide results in decreased expression of SDHA mRNA16297948
D013893ThiramThiram results in decreased expression of SDHA mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SDHA protein22609517
C479163tofacitinibtofacitinib results in increased expression of SDHA protein25487280
C066340tolcaponetolcapone binds to SDHA protein19783845
D014050TolueneToluene affects the expression of SDHA mRNA21827849
D014238Trichloroacetic AcidTrichloroacetic Acid results in increased expression of SDHA mRNA14565619
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SDHA gene27618143
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of SDHA protein]19634143|2113669
C057693troglitazonetroglitazone results in increased expression of SDHA protein21315101
D014415TunicamycinTunicamycin results in increased expression of SDHA mRNA22378314
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of SDHA mRNA]12710931
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SDHA gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SDHA mRNA26682919
C111237vorinostatvorinostat results in increased expression of SDHA protein20543569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000104succinate dehydrogenase activity-IBA21873635  
GO:0000104succinate dehydrogenase activitycontributes_toIMP7550341  
GO:0005515protein binding-IPI15961414  19628817  19688755  23747254  24606901  26496610  
26749241  28330616  
GO:0008177succinate dehydrogenase (ubiquinone) activity-IBA21873635  
GO:0008177succinate dehydrogenase (ubiquinone) activity-IMP24781757  
GO:0009055electron transfer activity-IBA21873635  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006099tricarboxylic acid cycle-IBA21873635  
GO:0006099tricarboxylic acid cycle-IEA-  
GO:0006099tricarboxylic acid cycle-TAS7550341  
GO:0006105succinate metabolic process-IDA7550341  
GO:0006121mitochondrial electron transport, succinate to ubiquinone-IBA21873635  
GO:0007399nervous system development-IMP16361598  
GO:0009061anaerobic respiration-IBA21873635  
GO:0022904respiratory electron transport chain-IDA7550341  
GO:0055114oxidation-reduction process-IDA7550341  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005739mitochondrion-IDA7550341  16826196  
GO:0005743mitochondrial inner membrane-ISS-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005749mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)-IBA21873635  
GO:0005749mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)-ISS-  
GO:0005749mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)-TAS7550341  
GO:0043209myelin sheath-IEA-  
GO:0045282plasma membrane succinate dehydrogenase complex-IBA21873635  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.IEA
R-HSA-611105Respiratory electron transportIEA
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301715Hereditary Paraganglioma-Pheochromocytoma Syndromes (1993)Kirmani S-
27667312Oxidative stress and ageing. (2016 Oct)Birch-Machin MABr J Dermatol
25803269Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)Filis PJ Clin Endocrinol Metab