Gene: THADA

63892
ARMC13|GITA
THADA, armadillo repeat containing
protein-coding
2p21
Ensembl:ENSG00000115970 MIM:611800 Vega:OTTHUMG00000152398 UniprotKB:Q6YHU6
NG_051580.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.474e-1 (AD)  9.691e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10101600chr2:43478743THADA4.100e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UTP200.812
CNOT100.797
NUP2140.785
SETX0.781
GEMIN50.78
NUDT50.776
MSH60.774
RRP1B0.774
NOL80.774
SMC60.773

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.464
OR4F29-0.449
DIO2-0.237
MUC7-0.214
TNNT1-0.199
ENDOU-0.199
OR4F16-0.197
SEC14L3-0.196
GSDMC-0.195
KLRC2-0.189

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of THADA mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of THADA gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of THADA mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of THADA mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of THADA mRNA"20382639|2623829
C018021cobaltous chloridecobaltous chloride results in decreased expression of THADA mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of THADA mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of THADA mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of THADA mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of THADA mRNA27392435
D002945CisplatinCisplatin results in decreased expression of THADA mRNA19561079
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of THADA gene23968726
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of THADA mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of THADA mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of THADA mRNA22634610
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of THADA mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of THADA mRNA"24972896
C042720mercuric bromidemercuric bromide results in decreased expression of THADA mRNA26272509
D008694MethamphetamineMethamphetamine results in decreased expression of THADA mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of THADA mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of THADA mRNA26011545
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of THADA gene23968726
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of THADA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of THADA mRNA20159946
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of THADA mRNA28065790
C012589trichostatin Atrichostatin A results in decreased expression of THADA mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of THADA mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions affects the methylation of THADA gene25560391
D014750VincristineVincristine results in increased expression of THADA mRNA23649840
D014810Vitamin EVitamin E results in increased expression of THADA mRNA19244175
C111237vorinostatvorinostat results in decreased expression of THADA mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0030488tRNA methylation-IBA21873635  
GO:0032471negative regulation of endoplasmic reticulum calcium ion concentration-IMP28399403  
GO:0055088lipid homeostasis-IGI28399403  
GO:1901895negative regulation of calcium-transporting ATPase activity-ISS-  
GO:1990845adaptive thermogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IBA21873635  
GO:0098554cytoplasmic side of endoplasmic reticulum membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6782315tRNA modification in the nucleus and cytosolTAS
R-HSA-72306tRNA processingTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23512105Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)Beaty THHum Genet