Gene: SDHB

6390
CWS2|IP|PGL4|SDH|SDH1|SDH2|SDHIP
succinate dehydrogenase complex iron sulfur subunit B
protein-coding
1p36.13
Ensembl:ENSG00000117118 MIM:185470 Vega:OTTHUMG00000002289 UniprotKB:P21912
NG_012340.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.202e-1 (AD)  5.863e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMC40.955
C1QBP0.954
UQCRFS10.953
VDAC20.952
MRPS70.949
CYC10.948
SUPT4H10.947
RHEB0.945
COX7B0.945
PRDX20.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.792
OR4F29-0.746
MTRNR2L6-0.344
MTRNR2L9-0.323
P2RY14-0.31
MTRNR2L10-0.298
CXCR2-0.296
KCNJ15-0.295
VNN3-0.294
IL18RAP-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in decreased expression of SDHB mRNA"11227219
D000082AcetaminophenAcetaminophen results in decreased expression of SDHB mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SDHB mRNA17562736
D001151ArsenicArsenic affects the methylation of SDHB gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of SDHB protein25419056
D001280AtrazineAtrazine results in decreased expression of SDHB mRNA25929836
D001280AtrazineAtrazine results in increased expression of SDHB mRNA22378314
D001280AtrazineAtrazine results in increased expression of SDHB mRNA18522720
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SDHB mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SDHB mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of SDHB protein25772901
C006780bisphenol Abisphenol A affects the expression of SDHB mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SDHB mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of SDHB protein28903499
D002104CadmiumCadmium results in increased expression of SDHB mRNA26187450
C100187chloropicrinchloropicrin results in increased expression of SDHB mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SDHB gene20938992
D003300CopperCopper results in decreased expression of SDHB mRNA22465980
D016572CyclosporineCyclosporine results in decreased expression of SDHB mRNA20106945
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of SDHB mRNA28659758
D064730DexrazoxaneDexrazoxane results in decreased expression of SDHB mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SDHB mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SDHB mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SDHB mRNA26924002
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA18313992
D004317DoxorubicinDoxorubicin results in decreased expression of SDHB mRNA26873546
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SDHB protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SDHB mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHB mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SDHB gene20938992
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of SDHB protein]20884965
D019833GenisteinGenistein results in decreased expression of SDHB protein20884965
D005839GentamicinsGentamicins results in increased expression of SDHB mRNA22061828
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein23293585
D006861Hydrogen Peroxideresveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein]23293585
D007538IsoniazidIsoniazid affects the expression of SDHB mRNA24848797
C008261lead acetatelead acetate results in decreased expression of SDHB mRNA21829687
C052901lemongrass oillemongrass oil affects the expression of SDHB mRNA25976427
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of SDHB mRNA18386188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SDHB gene20938992
D008767Methylmercury CompoundsCCL2 protein affects the reaction [Methylmercury Compounds results in decreased expression of SDHB mRNA]22837723
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SDHB mRNA22837723
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SDHB mRNA12463572
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SDHB mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SDHB protein26102036
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SDHB mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SDHB mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SDHB mRNA"25554681
C022838nickel chloridenickel chloride results in increased expression of SDHB mRNA26378417
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of SDHB protein19716841
C030110oxaliplatinoxaliplatin results in decreased expression of SDHB mRNA17762391
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of SDHB mRNA18386188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SDHB protein26879310
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of SDHB mRNA28659758
D010695PhlorhizinPhlorhizin results in increased expression of SDHB mRNA22538082
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of SDHB mRNA28659758
C059514resveratrolresveratrol results in increased expression of SDHB protein24365713
C059514resveratrolresveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein]23293585
C059514resveratrolresveratrol results in increased expression of SDHB mRNA22610192
C059514resveratrolresveratrol results in increased expression of SDHB protein25394648|2550515
C089730rosiglitazonerosiglitazone affects the expression of SDHB mRNA22013433
C049705S-1,2-dichlorovinyl-N-acetylcysteine"S-1,2-dichlorovinyl-N-acetylcysteine affects the expression of SDHB mRNA"16844155
C541923sandostatinLARsandostatinLAR results in decreased expression of SDHB mRNA17210224
C017947sodium arsenitesodium arsenite results in increased expression of SDHB protein27908234
D018038Sodium SeleniteSodium Selenite results in increased expression of SDHB mRNA18175754
D019311Staurosporine[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein23293585
D019311Staurosporineresveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SDHB protein]23293585
D013311StreptozocinStreptozocin results in increased expression of SDHB protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of SDHB protein]19634143
D013629TamoxifenTamoxifen affects the expression of SDHB mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SDHB mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SDHB mRNA21215274
C066340tolcaponetolcapone binds to SDHB protein19783845
D014050TolueneToluene affects the expression of SDHB mRNA21827849
D014212TretinoinTretinoin results in increased expression of SDHB mRNA17218384
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of SDHB protein]19634143
D014635Valproic AcidValproic Acid results in increased expression of SDHB mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SDHB gene25560391
D015215ZidovudineZidovudine results in decreased expression of SDHB mRNA16894629
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15961414  19688755  24606901  26749241  28380382  
GO:0008177succinate dehydrogenase (ubiquinone) activity-IEA-  
GO:0009055electron transfer activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0048039ubiquinone binding-ISS-  
GO:00515372 iron, 2 sulfur cluster binding-ISS-  
GO:00515383 iron, 4 sulfur cluster binding-ISS-  
GO:00515394 iron, 4 sulfur cluster binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006099tricarboxylic acid cycle-IEA-  
GO:0006105succinate metabolic process-IEA-  
GO:0009060aerobic respiration-IBA21873635  
GO:0009060aerobic respiration-TAS2302193  
GO:0022904respiratory electron transport chain-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-ISS-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005749mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)-ISS-  
GO:0005886plasma membrane-IDA-  
GO:0031966mitochondrial membrane-IBA21873635  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.IEA
R-HSA-611105Respiratory electron transportIEA
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301715Hereditary Paraganglioma-Pheochromocytoma Syndromes (1993)Kirmani S-
21561594[SDHB expression in Warthin's tumour]. (2011 Sep-Oct)Vera-Sirera BActa Otorrinolaringol Esp
27667312Oxidative stress and ageing. (2016 Oct)Birch-Machin MABr J Dermatol