Gene: FAM111A

63901
GCLEB|KCS2
family with sequence similarity 111 member A
protein-coding
11q12.1
Ensembl:ENSG00000166801 MIM:615292 Vega:OTTHUMG00000167280 UniprotKB:Q96PZ2
NG_042835.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.240e-1 (AD)  5.052e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CFLAR0.865
CASP100.857
PARP140.853
UBA70.852
CARD80.841
TRIM380.832
BTN3A10.832
SAMD9L0.827
PARP90.816
KDELC20.813

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS1-0.486
MYADML2-0.485
BCL11A-0.475
KCNB2-0.474
SLC7A4-0.466
FBLL1-0.465
ABCC12-0.459
GSG1-0.458
SPEF1-0.454
ATOH7-0.449

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of FAM111A mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FAM111A mRNA"27291303
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of FAM111A mRNA"19167446
D000082AcetaminophenAcetaminophen results in decreased expression of FAM111A mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of FAM111A mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of FAM111A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FAM111A protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAM111A gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FAM111A mRNA23630614
D000393Air PollutantsAir Pollutants analog results in decreased expression of FAM111A mRNA21757418
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of FAM111A mRNA"22863853
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FAM111A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAM111A mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FAM111A mRNA21569818|2719552
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FAM111A mRNA"26238291
C006780bisphenol Abisphenol A results in decreased expression of FAM111A mRNA29275510
C006780bisphenol Abisphenol A affects the expression of FAM111A mRNA25181051
D002065BuspironeBuspirone results in decreased expression of FAM111A mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of FAM111A mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FAM111A mRNA27339419
D002509CephaloridineCephaloridine results in decreased expression of FAM111A mRNA18500788
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FAM111A mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of FAM111A mRNA19549813
C030123coumarincoumarin results in increased expression of FAM111A mRNA18480146
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of FAM111A mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of FAM111A mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of FAM111A mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of FAM111A mRNA20106945|2556210
D003561CytarabineCytarabine results in increased expression of FAM111A mRNA19194470
C014347decitabinedecitabine results in increased expression of FAM111A mRNA19194470
D003703DemecolcineDemecolcine results in decreased expression of FAM111A mRNA23649840
D002945CisplatinCisplatin results in increased expression of FAM111A mRNA27594783
D002945CisplatinCisplatin results in decreased expression of FAM111A mRNA22023808
D019422Dietary SucroseDietary Sucrose results in increased expression of FAM111A mRNA26033743
C118739entinostatentinostat results in increased expression of FAM111A mRNA27188386
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of FAM111A mRNA24412560
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of FAM111A mRNA24412560
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of FAM111A mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of FAM111A mRNA23649840
C039281furanfuran results in increased expression of FAM111A mRNA25539665
C492448ICG 001ICG 001 results in decreased expression of FAM111A mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FAM111A mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FAM111A mRNA24796395
C045463leflunomideleflunomide results in decreased expression of FAM111A mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FAM111A mRNA23649840
C523799MRK 003MRK 003 results in decreased expression of FAM111A mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FAM111A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FAM111A mRNA"25554681
C570897NSC668394NSC668394 results in decreased expression of FAM111A mRNA27137931
C500026palbociclibpalbociclib results in decreased expression of FAM111A mRNA22869556
C410127PCB 180PCB 180 results in increased expression of FAM111A mRNA23829299
D010416PentachlorophenolPentachlorophenol results in increased expression of FAM111A mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FAM111A mRNA22237054
C006253pirinixic acidpirinixic acid results in increased expression of FAM111A mRNA19162173
D010894PiroxicamPiroxicam results in increased expression of FAM111A mRNA21858171
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FAM111A mRNA27029645
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of FAM111A mRNA19167446
C089730rosiglitazonerosiglitazone results in decreased expression of FAM111A mRNA25572481
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of FAM111A mRNA19244175
D012643SeleniumSelenium results in decreased expression of FAM111A mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of FAM111A mRNA25351596
C016104sodium bichromatesodium bichromate affects the expression of FAM111A mRNA22110744
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM111A mRNA22574217
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FAM111A mRNA25613284
D019772TopotecanFAM111A protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of FAM111A mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of FAM111A gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FAM111A mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of FAM111A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FAM111A mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of FAM111A mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of FAM111A mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FAM111A gene25560391
C025643vinclozolinvinclozolin affects the expression of FAM111A mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of FAM111A mRNA26682919
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of FAM111A mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of FAM111A mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of FAM111A mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23093934  24561620  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-IMP24561620  
GO:0016032viral process-IEA-  
GO:0045071negative regulation of viral genome replication-IMP23093934  
GO:0051607defense response to virus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IDA24561620  
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA23093934  24561620  
GO:0005737cytoplasm-IDA23093934  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26455281Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. (2015 Dec)Stankiewicz AMPharmacol Biochem Behav