Gene: SDHC

6391
CYB560|CYBL|PGL3|QPS1|SDH3
succinate dehydrogenase complex subunit C
protein-coding
1q23.3
Ensembl:ENSG00000143252 MIM:602413 Vega:OTTHUMG00000034468 UniprotKB:Q99643
NG_012767.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.649e-1 (AD)  1.764e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLNS1A0.914
PDE6D0.909
RAB5C0.893
FAM120AOS0.89
ADH50.884
MED290.884
SRP90.884
DAZAP20.883
ETFA0.882
PRDX30.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.827
OR4F29-0.813
RAX2-0.214
C17orf112-0.198
MMP23B-0.193
OR6C74-0.175
NANOS2-0.175
PRAMEF8-0.171
KRTAP4-8-0.166
EPPIN-0.165

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0069834-chlorobiphenyl4-chlorobiphenyl metabolite results in decreased expression of SDHC mRNA25417049
D000082AcetaminophenAcetaminophen results in decreased expression of SDHC mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SDHC mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SDHC gene27153756
D000638AmiodaroneAmiodarone affects the expression of SDHC mRNA19483382
C006632arsenic trioxidearsenic trioxide results in increased expression of SDHC mRNA22521957
D001280AtrazineAtrazine results in decreased expression of SDHC mRNA22378314|2711463
D001280AtrazineAtrazine results in decreased expression of SDHC mRNA27114639
D001553BenzbromaroneBenzbromarone affects the expression of SDHC mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SDHC mRNA22209252
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SDHC mRNA]22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of SDHC mRNA21179406
C006780bisphenol Abisphenol A affects the expression of SDHC mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SDHC mRNA29027980
C006780bisphenol Abisphenol A results in increased expression of SDHC mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SDHC gene28505145
D000069286BortezomibBortezomib results in decreased expression of SDHC mRNA20977926
D002104CadmiumCadmium results in increased expression of SDHC mRNA26187450
D002994ClofibrateClofibrate results in decreased expression of SDHC mRNA17585979
D002994ClofibrateClofibrate affects the expression of SDHC mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of SDHC mRNA19376846
D003300CopperCopper results in decreased expression of SDHC mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of SDHC mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SDHC mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SDHC mRNA]27941970
D064730DexrazoxaneDexrazoxane affects the expression of SDHC mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SDHC mRNA17361019|2126653
D002945CisplatinCisplatin results in decreased expression of SDHC mRNA27594783
D002945CisplatinCisplatin results in increased expression of SDHC mRNA27392435
D004317DoxorubicinDoxorubicin results in decreased expression of SDHC mRNA26873546
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SDHC mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHC mRNA17942748
D005001EthionineEthionine affects the expression of SDHC mRNA19483382
D005485FlutamideFlutamide results in increased expression of SDHC mRNA21126777
D005485FlutamideFlutamide results in increased expression of SDHC mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of SDHC mRNA23649840
C010974glyphosateglyphosate results in decreased expression of SDHC mRNA26302742
D007213IndomethacinIndomethacin results in increased expression of SDHC mRNA28201806
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of SDHC mRNA15476862
C410337K 7174K 7174 results in decreased expression of SDHC mRNA24086573
D007854LeadLead affects the splicing of SDHC mRNA28903495
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of SDHC protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of SDHC protein26558463
D008777MethyltestosteroneMethyltestosterone results in increased expression of SDHC mRNA29191790
C051752nefazodonenefazodone results in increased expression of SDHC mRNA24136188
C012655nimesulidenimesulide results in increased expression of SDHC mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of SDHC mRNA19483382
D010634PhenobarbitalPhenobarbital affects the expression of SDHC mRNA19159669
C006253pirinixic acidpirinixic acid affects the expression of SDHC mRNA19483382
C422648pluronic block copolymer p85pluronic block copolymer p85 results in decreased expression of SDHC mRNA16579640
D011441PropylthiouracilPropylthiouracil affects the expression of SDHC mRNA19483382
D011794QuercetinQuercetin results in decreased expression of SDHC mRNA15309432
D011794QuercetinQuercetin results in decreased expression of SDHC protein14750173|1522177
D015474IsotretinoinIsotretinoin results in decreased expression of SDHC mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of SDHC mRNA22013433
D012715Sesame OilSesame Oil results in decreased expression of SDHC mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SDHC mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SDHC mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SDHC mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHC mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SDHC mRNA21354282
D013792ThalidomideThalidomide results in decreased expression of SDHC mRNA26217789
D019284ThapsigarginThapsigargin results in decreased expression of SDHC mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of SDHC mRNA19483382
D014050TolueneToluene affects the expression of SDHC mRNA21827849
D014241TrichloroethyleneTrichloroethylene affects the expression of SDHC mRNA21135412
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SDHC gene27618143
D014415TunicamycinTunicamycin results in decreased expression of SDHC mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of SDHC mRNA17292431
D014810Vitamin EVitamin E results in increased expression of SDHC mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000104succinate dehydrogenase activity-IEA-  
GO:0008177succinate dehydrogenase (ubiquinone) activityCONTRIBUTES_TOIBA21873635  
GO:0009055electron transfer activity-IBA21873635  
GO:0009055electron transfer activity-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0048039ubiquinone binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006099tricarboxylic acid cycle-IEA-  
GO:0006099tricarboxylic acid cycle-TAS9533030  
GO:0006121mitochondrial electron transport, succinate to ubiquinone-IBA21873635  
GO:0006979response to oxidative stress-IBA21873635  
GO:0009060aerobic respiration-TAS9533030  
GO:0055114oxidation-reduction process-TAS9533030  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-TAS2302193  
GO:0005743mitochondrial inner membrane-ISS-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005749mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)-IBA21873635  
GO:0005749mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)-ISS-  
GO:0016021integral component of membrane-TAS9533030  
GO:0045273respiratory chain complex II-TAS9533030  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.IEA
R-HSA-611105Respiratory electron transportIEA
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301715Hereditary Paraganglioma-Pheochromocytoma Syndromes (1993)Kirmani S-
28542447Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women. (2017)Wang XPLoS One