Gene: SDHD

6392
CBT1|CII-4|CWS3|PGL|PGL1|QPs3|SDH4|cybS
succinate dehydrogenase complex subunit D
protein-coding
11q23.1
Ensembl:ENSG00000204370 MIM:602690 Vega:OTTHUMG00000166997 UniprotKB:O14521
NG_012337.3
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.035e-1 (AD)  7.100e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRDX30.923
RAB100.919
PAICS0.915
SRP90.909
GLO10.909
ITM2B0.901
ADH50.9
CNBP0.892
ABI10.888
TMCO10.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.799
OR4F29-0.76
OR6C74-0.196
CETP-0.171
HMHB1-0.162
AKR1B15-0.155
SPRR2B-0.142
FCRL1-0.142
KRTAP4-8-0.141
OR7C2-0.139

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SDHD mRNA"19114083
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in decreased expression of SDHD mRNA"11227219
C0069834-chlorobiphenyl4-chlorobiphenyl metabolite results in decreased expression of SDHD mRNA25417049
D000082AcetaminophenAcetaminophen results in decreased expression of SDHD mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SDHD mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SDHD gene27153756
D000638AmiodaroneAmiodarone affects the expression of SDHD mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SDHD mRNA25339124
D001280AtrazineAtrazine results in decreased expression of SDHD mRNA25929836
D001280AtrazineAtrazine results in decreased expression of SDHD mRNA22378314
D001553BenzbromaroneBenzbromarone affects the expression of SDHD mRNA19483382
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SDHD mRNA]22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of SDHD mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of SDHD mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SDHD mRNA28628672
D002994ClofibrateClofibrate affects the expression of SDHD mRNA19483382
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SDHD mRNA17602206
D016572CyclosporineCyclosporine results in decreased expression of SDHD mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SDHD mRNA28628672
D064730DexrazoxaneDexrazoxane results in decreased expression of SDHD mRNA26873546
C000944dicrotophosdicrotophos results in decreased expression of SDHD mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SDHD mRNA17602206
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SDHD mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHD mRNA17942748
D005001EthionineEthionine affects the expression of SDHD mRNA19483382
D005839GentamicinsGentamicins results in increased expression of SDHD mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of SDHD mRNA22634610
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SDHD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SDHD mRNA28628672
D007538IsoniazidIsoniazid affects the expression of SDHD mRNA24848797
C410337K 7174K 7174 results in decreased expression of SDHD mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of SDHD mRNA16807920
C052901lemongrass oillemongrass oil affects the expression of SDHD mRNA25976427
D009853OmeprazoleOmeprazole affects the expression of SDHD mRNA19483382
D010269ParaquatParaquat results in increased expression of SDHD mRNA21371552
C006253pirinixic acidpirinixic acid affects the expression of SDHD mRNA19483382
D011441PropylthiouracilPropylthiouracil affects the expression of SDHD mRNA19483382
C059514resveratrolresveratrol results in increased expression of SDHD mRNA22610192
C089730rosiglitazonerosiglitazone affects the expression of SDHD mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of SDHD mRNA17245590
D012999SomanSoman results in decreased expression of SDHD mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SDHD mRNA17101203|2315218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SDHD mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHD mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SDHD mRNA17942748
D013853ThioacetamideThioacetamide affects the expression of SDHD mRNA19483382
D014050TolueneToluene affects the expression of SDHD mRNA21827849
D014415TunicamycinTunicamycin results in decreased expression of SDHD mRNA17127020
D015215ZidovudineZidovudine results in increased expression of SDHD mRNA16894629

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000104succinate dehydrogenase activity-IDA9533030  
GO:0008177succinate dehydrogenase (ubiquinone) activityCONTRIBUTES_TOIBA21873635  
GO:0009055electron transfer activity-TAS9533030  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0048039ubiquinone binding-IBA21873635  
GO:0048039ubiquinone binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006099tricarboxylic acid cycle-IBA21873635  
GO:0006099tricarboxylic acid cycle-IDA9533030  
GO:0006099tricarboxylic acid cycle-IEA-  
GO:0006121mitochondrial electron transport, succinate to ubiquinone-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-TAS2302193  
GO:0005740mitochondrial envelope-TAS9533030  
GO:0005743mitochondrial inner membrane-IDA9533030  
GO:0005743mitochondrial inner membrane-ISS-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005749mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)-IBA21873635  
GO:0005749mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)-ISS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportIEA
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.IEA
R-HSA-611105Respiratory electron transportIEA
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301715Hereditary Paraganglioma-Pheochromocytoma Syndromes (1993)Kirmani S-