Gene info: ID 63923

Gene: TNN

GENE ID: 63923

Synonyms: TN-W

Description: tenascin N

Gene type: protein-coding

Location: 1q25.1

dbXrefs: Ensembl:ENSG00000120332 MIM:617472 Vega:OTTHUMG00000034882 UniprotKB:Q9UQP3

RefSeq: NC_000001.11

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : 5.820e-1 (AD) 9.708e-1 (ND) (Frontal_Cortex)

Pascal p-value : 7.049e-5 (AD) 5.060e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2157588	chr1:175138690 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs12094153	chr1:175124889 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg20240091	chr1:175044916	TNN		1.100e-11	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GRIN3A	0.65
XKR4	0.648
IL12RB2	0.619
PPEF1	0.619
PCDHAC2	0.612
TMEM169	0.612
EPHA5	0.611
IQCJ-SCHIP1	0.604
NOV	0.604
SPHKAP	0.602

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAB13	-0.443
STON2	-0.427
ROM1	-0.424
AKR1C3	-0.422
HEBP2	-0.409
IMPA2	-0.408
CSAG1	-0.403
HVCN1	-0.398
NBPF10	-0.396
TMEM176A	-0.396

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of TNN mRNA"	26377693
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of TNN mRNA"	25710175
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of TNN gene	27153756
C547126	AZM551248	AZM551248 results in increased expression of TNN mRNA	22323515
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of TNN gene	25435355
C006780	bisphenol A	bisphenol A results in decreased expression of TNN mRNA	25181051
D003300	Copper	Copper deficiency results in increased expression of TNN mRNA	26033743
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TNN mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of TNN mRNA	21266533
D002117	Calcitriol	Calcitriol results in decreased expression of TNN mRNA	16002434
C118739	entinostat	entinostat results in increased expression of TNN mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of TNN mRNA	23649840
D005557	Formaldehyde	Formaldehyde results in increased expression of TNN mRNA	23649840
C039281	furan	furan results in increased expression of TNN mRNA	27387713
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of TNN mRNA"	24972896
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TNN mRNA	23458150
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TNN mRNA	23649840
D016686	Monocrotaline	Monocrotaline results in increased expression of TNN protein	24947524
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TNN mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TNN mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of TNN mRNA	24768652\|2558310
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of TNN mRNA	26272509
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of TNN mRNA	26705709
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TNN mRNA	24780913
D015474	Isotretinoin	Isotretinoin results in increased expression of TNN mRNA	20436886
D012402	Rotenone	Rotenone results in decreased expression of TNN mRNA	27979718
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of TNN mRNA	27257137
D053260	Soot	Soot results in decreased expression of TNN mRNA	26551751
D013893	Thiram	Thiram results in increased expression of TNN mRNA	20530235
C009495	titanium dioxide	titanium dioxide results in decreased expression of TNN mRNA	19464567
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TNN mRNA	20133372
C012589	trichostatin A	trichostatin A results in decreased expression of TNN mRNA	15901671
C012589	trichostatin A	trichostatin A results in increased expression of TNN mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of TNN mRNA	19042947
D014635	Valproic Acid	Valproic Acid results in decreased expression of TNN mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in increased expression of TNN mRNA	24383497\|2493525
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of TNN gene	25560391
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNN mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of TNN mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003674	molecular_function	-	ND	-
GO:0005178	integrin binding	-	IEA	-
GO:0042802	identical protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002076	osteoblast development	-	ISS	-
GO:0007160	cell-matrix adhesion	-	IEA	-
GO:0007409	axonogenesis	-	IEA	-
GO:0033689	negative regulation of osteoblast proliferation	-	ISS	-
GO:0045668	negative regulation of osteoblast differentiation	-	ISS	-
GO:0070593	dendrite self-avoidance	-	ISA	12812753
GO:1905240	negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation	-	ISS	-
GO:2001223	negative regulation of neuron migration	-	ISA	12812753

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005575	cellular_component	-	ND	-
GO:0005576	extracellular region	-	IEA	-
GO:0009986	cell surface	-	IEA	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0097442	CA3 pyramidal cell dendrite	-	IEA	-
GO:1990026	hippocampal mossy fiber expansion	-	IEA	-

KEGG ID	KEGG Term
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-3000178	ECM proteoglycans	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24046282	Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity. (2013 Nov 15)	Brenner M	Physiol Genomics
21956439	Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. (2012 Jan)	Zuo L	Neuropsychopharmacology