Gene info: ID 63950

Gene: DMRTA2

GENE ID: 63950

Synonyms: -

Description: DMRT like family A2

Gene type: protein-coding

Location: 1p32.3

dbXrefs: Ensembl:ENSG00000142700 MIM:614804 Vega:OTTHUMG00000007884 UniprotKB:Q96SC8

RefSeq: NC_000001.11

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.504e-2 (AD) 2.208e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1278530	chr1:50423583 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DMBT1	0.775
TMEM139	0.758
LRRC63	0.747
NIPAL4	0.746
DNAH17	0.745
TRIM59	0.744
SMIM5	0.743
MYO1D	0.733
ST18	0.726
SH3TC2	0.724

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TNNT1	-0.3
SLC29A4	-0.271
NHS	-0.27
GRB14	-0.27
MS4A8	-0.269
CALB2	-0.267
CUX2	-0.265
NR2F2	-0.264
MT1H	-0.261
ARHGAP10	-0.251

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DMRTA2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DMRTA2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DMRTA2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DMRTA2 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of DMRTA2 gene	27153756
D001151	Arsenic	Arsenic results in increased methylation of DMRTA2 promoter	21291286
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DMRTA2 mRNA	22228805
C006780	bisphenol A	bisphenol A affects the methylation of DMRTA2 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of DMRTA2 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of DMRTA2 mRNA	26079696
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DMRTA2 gene	20938992
D003471	Cuprizone	Cuprizone results in increased expression of DMRTA2 mRNA	26577399
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DMRTA2 gene	20938992
C069837	fullerene C60	fullerene C60 results in increased expression of DMRTA2 mRNA	19167457
D008344	Maneb	[Paraquat co-treated with Maneb] affects the expression of DMRTA2 mRNA	22563483
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DMRTA2 gene	20938992
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DMRTA2 mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DMRTA2 mRNA"	20188158
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DMRTA2 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of DMRTA2 mRNA	26272509
D010269	Paraquat	[Paraquat co-treated with Maneb] affects the expression of DMRTA2 mRNA	22563483
D010269	Paraquat	Paraquat results in decreased expression of DMRTA2 mRNA	22563483
C046012	pentanal	pentanal results in increased expression of DMRTA2 mRNA	26079696
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of DMRTA2 mRNA	27029645
C428725	pyridaben	pyridaben results in decreased expression of DMRTA2 mRNA	22563483
C017947	sodium arsenite	sodium arsenite results in increased expression of DMRTA2 mRNA	16014739
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DMRTA2 mRNA	24058054
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of DMRTA2 mRNA	28065790
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DMRTA2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of DMRTA2 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid results in increased expression of DMRTA2 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in decreased expression of DMRTA2 mRNA	21427059
D014635	Valproic Acid	Valproic Acid results in increased expression of DMRTA2 mRNA	21427059
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of DMRTA2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0042803	protein homodimerization activity	-	IBA	21873635
GO:0042803	protein homodimerization activity	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002052	positive regulation of neuroblast proliferation	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	-
GO:0007548	sex differentiation	-	IBA	21873635
GO:0021796	cerebral cortex regionalization	-	IEA	-
GO:0035914	skeletal muscle cell differentiation	-	IEA	-
GO:0048665	neuron fate specification	-	IEA	-
GO:0071542	dopaminergic neuron differentiation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal