Gene: SEC14L1

6397
PRELID4A|SEC14L
SEC14 like lipid binding 1
protein-coding
17q25.2-q25.3
Ensembl:ENSG00000129657 MIM:601504 Vega:OTTHUMG00000177311 UniprotKB:Q92503
NG_050640.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.346e-1 (AD)  3.024e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2053568chr17:77113218 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13868393chr17:75136249SEC14L1Promoter5.374e-4Alcohol use disorders26763658
cg11348106chr17:75208807SEC14L12.480e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABLIM10.806
TPP10.805
FYN0.8
SORBS10.797
MTMR30.791
CTDSP20.79
CLU0.789
CD590.785
NTRK30.784
MGAT10.781

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.637
OR4F5-0.637
NKX2-8-0.292
TSPAN8-0.269
GHRH-0.202
CHP2-0.2
TNFRSF13B-0.195
SLC27A6-0.193
HOXD1-0.192
ZNF683-0.187

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolSEC14L1 protein results in decreased susceptibility to 1-UFT protocol16734730
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SEC14L1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SEC14L1 gene27153756
D001280AtrazineAtrazine results in increased expression of SEC14L1 mRNA25929836
D001280AtrazineAtrazine results in increased expression of SEC14L1 mRNA22378314
D001507BeclomethasoneBeclomethasone results in increased expression of SEC14L1 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SEC14L1 mRNA26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SEC14L1 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SEC14L1 mRNA"26238291
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SEC14L1 mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of SEC14L1 mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of SEC14L1 mRNA25047013
C006780bisphenol Abisphenol A results in increased methylation of SEC14L1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of SEC14L1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SEC14L1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SEC14L1 mRNA15336504
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SEC14L1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of SEC14L1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of SEC14L1 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of SEC14L1 mRNA22077320
D016572CyclosporineCyclosporine results in increased expression of SEC14L1 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of SEC14L1 mRNA21198554
D002117CalcitriolCalcitriol results in increased expression of SEC14L1 mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SEC14L1 mRNA21592394
D004237DiuronDiuron results in increased expression of SEC14L1 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SEC14L1 mRNA22079256
D005472FluorouracilSEC14L1 protein affects the susceptibility to Fluorouracil16217747
D004397FonofosFonofos results in decreased methylation of SEC14L1 promoter22847954
C069837fullerene C60fullerene C60 results in increased expression of SEC14L1 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of SEC14L1 mRNA22061828
C410337K 7174K 7174 results in increased expression of SEC14L1 mRNA24086573
D008694MethamphetamineMethamphetamine affects the methylation of SEC14L1 promoter26307267
D008694MethamphetamineMethamphetamine results in increased expression of SEC14L1 mRNA26307267
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SEC14L1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SEC14L1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of SEC14L1 mRNA19167457
D010278ParathionParathion results in decreased methylation of SEC14L1 promoter22847954
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SEC14L1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SEC14L1 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of SEC14L1 mRNA23018184
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SEC14L1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of SEC14L1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of SEC14L1 mRNA18037150|1807036
D011441PropylthiouracilPropylthiouracil results in decreased expression of SEC14L1 mRNA24780913
C059514resveratrolresveratrol results in increased expression of SEC14L1 mRNA23419489
C078903seocalcitolseocalcitol results in increased expression of SEC14L1 mRNA12040012
D012906SmokeSmoke results in increased expression of SEC14L1 mRNA21095227
C012568terbufosterbufos results in decreased methylation of SEC14L1 promoter22847954
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SEC14L1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SEC14L1 mRNA21592394
C004648testosterone enanthatetestosterone enanthate affects the expression of SEC14L1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SEC14L1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SEC14L1 mRNA21570461|2468072
D019772TopotecanSEC14L1 protein affects the susceptibility to Topotecan16217747
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SEC14L1 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SEC14L1 mRNA"24407104
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SEC14L1 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of SEC14L1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of SEC14L1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SEC14L1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SEC14L1 mRNA23034163
D002762CholecalciferolCholecalciferol results in increased expression of SEC14L1 mRNA16508948

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17092608  
GO:0039552RIG-I binding-IPI23843640  
GO:0098772molecular function regulator-IDA23843640  
GO ID GO Term Qualifier Evidence PubMed
GO:0015871choline transport-IDA17092608  
GO:0039536negative regulation of RIG-I signaling pathway-IMP23843640  
GO:0045087innate immune response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IC23843640  
GO:0005737cytoplasm-IDA17092608  
GO:0005794Golgi apparatuscolocalizes_withIDA17092608  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal