Gene: MYO1G

64005
HA2|HLA-HA2|MHAG
myosin IG
protein-coding
7p13
Ensembl:ENSG00000136286 MIM:600642 Vega:OTTHUMG00000155821 UniprotKB:B0I1T2
NC_000007.14
PubMed
0   ANCO-SNPs
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.116e-1 (AD)  2.104e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12803068chr7:45002919MYO1G2.800e-90Maternal smoking in pregnancy27040690
cg04180046chr7:45002736MYO1G6.300e-91Maternal smoking in pregnancy27040690
cg22132788chr7:45002486MYO1G4.300e-64Maternal smoking in pregnancy27040690
cg19089201chr7:45002287MYO1G3.880e-48Maternal smoking in pregnancy27040690
cg12803068chr7:45002919MYO1G2.640e-134Maternal smoking in pregnancy27040690
cg04180046chr7:45002736MYO1G4.180e-124Maternal smoking in pregnancy27040690
cg22132788chr7:45002486MYO1G2.850e-100Maternal smoking in pregnancy27040690
cg19089201chr7:45002287MYO1G3.560e-78Maternal smoking in pregnancy27040690
cg12803068chr7:45002919MYO1G5.570e-128Maternal smoking in pregnancy27040690
cg04180046chr7:45002736MYO1G1.990e-123Maternal smoking in pregnancy27040690
cg22132788chr7:45002486MYO1G2.070e-100Maternal smoking in pregnancy27040690
cg19089201chr7:45002287MYO1G2.400e-78Maternal smoking in pregnancy27040690
cg12803068chr7:45002919MYO1G1.310e-22Maternal smoking in pregnancy27040690
cg04180046chr7:45002736MYO1G3.250e-18Maternal smoking in pregnancy27040690
cg22132788chr7:45002486MYO1G1.860e-20Maternal smoking in pregnancy27040690
cg19089201chr7:45002287MYO1G1.330e-20Maternal smoking in pregnancy27040690
cg12803068chr7:45002919MYO1G9.100e-23Smoking27651444
cg22132788chr7:45002486MYO1G8.100e-19Smoking27651444
cg04180046chr7:45002736MYO1G1.300e-17Smoking27651444
cg19089201chr7:45002287MYO1G1.600e-15Smoking27651444
cg07826859chr7:45020086MYO1G1.300e-12Smoking27651444
cg22132788chr7:45002486MYO1G9.410e-23Tobacco smoking28225026
cg12803068chr7:45002919MYO1G9.560e-22Tobacco smoking28225026
cg04180046chr7:45002736MYO1G8.490e-14Tobacco smoking28225026
cg19089201chr7:45002287MYO1G2.500e-12Tobacco smoking28225026
cg07826859chr7:45020086MYO1G6.480e-11Tobacco smoking28225026
cg12803068chr7:45002919MYO1G8.560e-14Smoking28686328
cg22132788chr7:45002486MYO1G2.100e-13Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL2A10.905
PIK3AP10.891
IL4I10.877
TLR10.876
RAC20.873
RUNX10.869
SLC11A10.867
LILRB10.866
PTPRC0.862
CD300A0.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.466
KCNIP3-0.46
TMEM179-0.451
NEUROD6-0.446
ZNF835-0.436
MARCH4-0.43
KCNA2-0.428
RNFT2-0.428
SCRT1-0.419
ANKRD34A-0.417

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5736932-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in increased expression of MYO1G mRNA22193206
D000082AcetaminophenAcetaminophen affects the expression of MYO1G mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MYO1G gene28458013
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MYO1G mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of MYO1G mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MYO1G mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MYO1G mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MYO1G mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MYO1G mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MYO1G mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYO1G mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MYO1G mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of MYO1G mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MYO1G gene28505145
D002104CadmiumCadmium results in decreased expression of MYO1G mRNA23358151
D019256Cadmium ChlorideCadmium Chloride affects the expression of MYO1G mRNA22110744
D002737ChloropreneChloroprene results in decreased expression of MYO1G mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MYO1G mRNA27858113
D003367CotinineCotinine affects the methylation of MYO1G gene22851337
D003471CuprizoneCuprizone results in increased expression of MYO1G mRNA27523638
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of MYO1G mRNA22193206
D005485FlutamideFlutamide results in increased expression of MYO1G mRNA24136188
D005839GentamicinsGentamicins results in increased expression of MYO1G mRNA22061828
D005897GlafenineGlafenine results in increased expression of MYO1G mRNA24136188
D017313FenretinideFenretinide results in decreased expression of MYO1G mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MYO1G mRNA23086925
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of MYO1G mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MYO1G mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of MYO1G mRNA19812364
C051752nefazodonenefazodone results in increased expression of MYO1G mRNA24136188
D009532NickelNickel results in increased expression of MYO1G mRNA25583101
C012655nimesulidenimesulide results in increased expression of MYO1G mRNA24136188
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MYO1G mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of MYO1G mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of MYO1G mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MYO1G mRNA19162173
C016104sodium bichromatesodium bichromate affects the expression of MYO1G mRNA22110744
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYO1G mRNA26377647
C009495titanium dioxidetitanium dioxide results in decreased expression of MYO1G mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of MYO1G mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of MYO1G gene26756918|2686493
D014520UrethaneUrethane results in decreased expression of MYO1G mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of MYO1G gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MYO1G gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IEA-  
GO:0003779actin binding-IEA-  
GO:0005516calmodulin binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-ISS-  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-ISS-  
GO:0008017microtubule binding-IEA-  
GO:0043325phosphatidylinositol-3,4-bisphosphate binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002456T cell mediated immunity-ISS-  
GO:0006887exocytosis-IEA-  
GO:0007018microtubule-based movement-IEA-  
GO:0031589cell-substrate adhesion-IEA-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-ISS-  
GO:0071976cell gliding-IEA-  
GO:0072678T cell migration-ISS-  
GO:0120117T cell meandering migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001891phagocytic cup-ISS-  
GO:0005886plasma membrane-IDA19968988  
GO:0005902microvillus-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016459myosin complex-IEA-  
GO:0030027lamellipodium-IEA-  
GO:0030175filopodium-IEA-  
GO:0031256leading edge membrane-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24485148Differences in smoking associated DNA methylation patterns in South Asians and Europeans. (2014 Feb 3)Elliott HRClin Epigenetics
25862628DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring. (2015 Aug)Kupers LKInt J Epidemiol
28494218Maternal cigarette smoking during pregnancy and offspring DNA methylation in midlife. (2018)Tehranifar PEpigenetics
27403598Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. (2016 Sep)Gonseth SEpigenetics
25552657Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). (2015 Apr 15)Richmond RCHum Mol Genet
26580635Assessment of Offspring DNA Methylation across the Lifecourse Associated with Prenatal Maternal Smoking Using Bayesian Mixture Modelling. (2015 Nov 13)de Vocht FInt J Environ Res Public Health
27171005Maternal Smoking during Pregnancy and DNA-Methylation in Children at Age 5.5 Years: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study. (2016)Rzehak PPLoS One
25325234Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age. (2015 Feb)Lee KWEnviron Health Perspect
29695247Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation. (2018 Apr 25)Witt SHBMC Genomics