Gene info: ID 6402

Gene: SELL

GENE ID: 6402

Description: selectin L

Gene type: protein-coding

Location: 1q24.2

dbXrefs: Ensembl:ENSG00000188404 MIM:153240 Vega:OTTHUMG00000034809 UniprotKB:P14151

RefSeq: NG_016132.1

Retrived from: PubMed|SNP Mapped

SNPs: 7 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.574e-1 (AD) 8.529e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2205849	chr1:169712216 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs4987285	chr1:169708883 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs1051091	chr1:169708568 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2205847	chr1:169707082 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs2229569	chr1:169704697 (GRCh38.p7)	G>A / G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs4987314	chr1:169703202 (GRCh38.p7)	C>G / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs964555	chr1:169701947 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSF3R	0.802
EVI2B	0.794
PLBD1	0.794
C19orf38	0.785
ALPK1	0.782
SERPINA1	0.781
RNASE2	0.773
RASGRP4	0.773
PTPRC	0.769
VNN2	0.769

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEUROD6	-0.589
ADRA1D	-0.559
MARCH4	-0.558
EXTL1	-0.554
CDH22	-0.551
ABCC12	-0.551
KCNIP3	-0.549
RTN4R	-0.543
SCRT1	-0.541
KCNQ4	-0.541

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SELL mRNA"	19114083
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]"	23452621
C056498	aceclofenac	aceclofenac results in decreased expression of SELL protein	12147693
D000082	Acetaminophen	Acetaminophen results in decreased expression of SELL mRNA	29067470
D000117	Acetylglucosamine	[Acetylglucosamine analog binds to Biotin] which binds to SELL protein	12191509
D000117	Acetylglucosamine	Acetylglucosamine analog binds to SELL protein	12191509
D000255	Adenosine Triphosphate	P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein]	11003599
C016601	afimoxifene	afimoxifene results in increased expression of SELL mRNA	19901195
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of SELL gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SELL mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SELL mRNA	24449571
D001241	Aspirin	Aspirin results in decreased expression of SELL protein	12147693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SELL mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SELL mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of SELL mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SELL mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SELL mRNA	21569818
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SELL mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of SELL mRNA	19619570
D001710	Biotin	[Acetylglucosamine analog binds to Biotin] which binds to SELL protein	12191509
C006780	bisphenol A	bisphenol A results in decreased expression of SELL mRNA	25181051
D019819	Budesonide	"Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELL mRNA]"	15734790
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in decreased expression of SELL mRNA	19925653
D000001	Calcimycin	Calcimycin results in decreased expression of SELL protein	18776917
D000001	Calcimycin	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of SELL mRNA]	21331654
D000001	Calcimycin	resveratrol analog inhibits the reaction [Calcimycin results in decreased expression of SELL protein]	18776917
D000001	Calcimycin	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of SELL mRNA	21331654
D002211	Capsaicin	Capsaicin results in increased expression of SELL protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of SELL protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELL protein]	22150557
D002726	Chlorogenic Acid	"[Chlorogenic Acid co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of SELL protein"	21414398
D002726	Chlorogenic Acid	"Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein]"	21414398
D002737	Chloroprene	Chloroprene results in decreased expression of SELL mRNA	23125180
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SELL mRNA	27858113
D002951	Citrates	Citrates results in decreased expression of SELL protein	8595612
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]	23452621
D016572	Cyclosporine	Cyclosporine results in decreased expression of SELL mRNA	20106945
C014347	decitabine	decitabine results in increased expression of SELL mRNA	19194470
D004008	Diclofenac	Diclofenac results in decreased expression of SELL protein	12147693
D004008	Diclofenac	Diclofenac results in increased expression of SELL mRNA	26934552
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of SELL mRNA	26033743
D004492	Edetic Acid	Edetic Acid results in decreased expression of SELL protein	8595612
D004656	Enalapril	[Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA	25037058
D004917	Erythromycin	Erythromycin results in increased expression of SELL protein	16297520
C004912	ethylbenzene	ethylbenzene results in increased expression of SELL mRNA	20955722
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of SELL mRNA	23649840
D005217	Fat Emulsions, Intravenous	"Fat Emulsions, Intravenous results in decreased expression of SELL protein"	26162596
D005419	Flavonoids	Flavonoids results in increased expression of SELL mRNA	15465739
D005419	Flavonoids	Flavonoids results in decreased expression of SELL mRNA	18035473
D005439	Flufenamic Acid	Flufenamic Acid results in decreased expression of SELL protein	12147693
D005480	Flurbiprofen	Flurbiprofen results in decreased expression of SELL protein	12147693
D005557	Formaldehyde	Formaldehyde results in decreased expression of SELL mRNA	23649840
D009240	N-Formylmethionine Leucyl-Phenylalanine	N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELL protein	21664406
C005023	fulvic acid	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of SELL mRNA]	21331654
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]	23452621
D005839	Gentamicins	Gentamicins results in increased expression of SELL mRNA	22061828
D006118	Griseofulvin	Griseofulvin results in decreased expression of SELL protein	11367519
D006493	Heparin	Heparin results in decreased expression of SELL protein	8595612
D006493	Heparin	Heparin results in increased expression of SELL protein	8993250
D007975	Leukotriene B4	Leukotriene B4 results in increased expression of SELL protein	14716214
D017313	Fenretinide	Fenretinide results in increased expression of SELL mRNA	28973697
D016285	Iloprost	Iloprost results in decreased expression of SELL protein	16363279
D007213	Indomethacin	Indomethacin results in decreased expression of SELL protein	11980903\|1214769
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SELL mRNA	25613284
D007545	Isoproterenol	Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]	9762784
D007660	Ketoprofen	Ketoprofen results in decreased expression of SELL protein	12147693
D008012	Lidocaine	Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]	9336308
C008288	Lipofundin	Lipofundin results in decreased expression of SELL protein	26162596
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein"	16389571
C433788	lipopolysaccharide, E. coli O26-B6	"Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein]"	16389571
C433788	lipopolysaccharide, E. coli O26-B6	"[Chlorogenic Acid co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of SELL protein"	21414398
C433788	lipopolysaccharide, E. coli O26-B6	"Chlorogenic Acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein]"	21414398
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein"	21414398
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELL mRNA]"	15734790
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELL mRNA"	15734790
C440499	lipopolysaccharide, Escherichia coli O111 B4	"resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELL mRNA]"	15734790
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of SELL	18639531
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of SELL protein	12734376
D008469	Meclofenamic Acid	Meclofenamic Acid results in decreased expression of SELL protein	12147693
D008528	Mefenamic Acid	Mefenamic Acid results in decreased expression of SELL protein	12147693
C065757	meloxicam	meloxicam affects the expression of SELL protein	12147693
D008727	Methotrexate	Methotrexate results in decreased expression of SELL mRNA	17400583\|2444957
D008752	Methylene Chloride	Methylene Chloride results in increased expression of SELL mRNA	20955722
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SELL mRNA	23649840
D009020	Morphine	Morphine results in decreased expression of SELL protein alternative form	10070497
D009020	Morphine	Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]	10070497
D009020	Morphine	phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]	10070497
D009151	Mustard Gas	Mustard Gas results in increased expression of SELL mRNA	25275893
C035605	nabumetone	nabumetone affects the expression of SELL protein	12147693
D009270	Naloxone	Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]	10070497
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of SELL mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SELL mRNA"	25554681
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of SELL protein]	22150557
D009532	Nickel	Nickel results in increased expression of SELL mRNA	25583101
C022838	nickel chloride	nickel chloride results in increased expression of SELL protein	12028813
C012655	nimesulide	nimesulide results in decreased expression of SELL protein	12147693
C056709	N,N-diacetylcystine	"N,N-diacetylcystine results in decreased expression of SELL protein"	17157857
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SELL mRNA	27935865
D009853	Omeprazole	Omeprazole results in decreased expression of SELL protein	17652263
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of SELL mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]	23452621
D010126	Ozone	Ozone results in increased expression of SELL mRNA	16330353
C084656	paricalcitol	[Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA	25037058
D010653	Phenylbutazone	Phenylbutazone affects the expression of SELL protein	12147693
C008890	phosphoramidon	phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]	10070497
C006253	pirinixic acid	pirinixic acid results in decreased expression of SELL mRNA	20813756
D010894	Piroxicam	Piroxicam affects the expression of SELL protein	12147693
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]	23452621
D010936	Plant Extracts	Plant Extracts results in increased expression of SELL mRNA	15465739
D010972	Platelet Activating Factor	Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]	9762784
D010972	Platelet Activating Factor	Platelet Activating Factor results in increased secretion of SELL protein	9762784
D010972	Platelet Activating Factor	Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]	9762784
D059808	Polyphenols	Polyphenols results in increased expression of SELL mRNA	15465739
D059808	Polyphenols	Polyphenols results in decreased expression of SELL mRNA	16293270
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of SELL mRNA	19162173
D011374	Progesterone	Progesterone results in decreased expression of SELL mRNA	23012394
D011794	Quercetin	"Quercetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of SELL protein]"	16389571
C062940	quinupristin-dalfopristin	quinupristin-dalfopristin results in increased expression of SELL protein	16297520
C059514	resveratrol	resveratrol analog inhibits the reaction [Calcimycin results in decreased expression of SELL protein]	18776917
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]	23452621
C059514	resveratrol	"resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELL mRNA]"	15734790
C059514	resveratrol	resveratrol results in decreased expression of SELL protein	21962734
C037663	ropivacaine	ropivacaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]	9336308
D012643	Selenium	Selenium results in increased expression of SELL mRNA	28810182
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SELL mRNA	23221170
D012834	Silver	Silver results in increased secretion of SELL protein	26702581
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of SELL protein]	22150557
C061133	tamibarotene	tamibarotene results in increased expression of SELL mRNA	15498508
C501413	tesaglitazar	tesaglitazar results in increased expression of SELL mRNA	21515302
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SELL mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SELL mRNA	19619570\|1990119
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SELL protein	15310856\|1868492
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SELL mRNA	26290441\|2756255
D013755	Tetradecanoylphorbol Acetate	fulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of SELL mRNA]	21331654
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of SELL mRNA	21331654
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SELL mRNA	25613284
D013792	Thalidomide	Thalidomide results in decreased expression of SELL protein	16344495
D013806	Theophylline	Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]	9762784
D013806	Theophylline	Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]	9762784
C009495	titanium dioxide	titanium dioxide results in increased expression of SELL mRNA	23557971
D014212	Tretinoin	Tretinoin results in increased expression of SELL mRNA	15498508
D014241	Trichloroethylene	Trichloroethylene results in increased expression of SELL mRNA	20955722
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SELL gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of SELL gene	25560391
C111237	vorinostat	vorinostat results in increased expression of SELL mRNA	20060208
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SELL mRNA	27935865
C088658	zoledronic acid	zoledronic acid results in increased expression of SELL mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	17548643
GO:0005509	calcium ion binding	-	IDA	28011641
GO:0005515	protein binding	-	IPI	18606703
GO:0008201	heparin binding	-	TAS	7680663
GO:0030246	carbohydrate binding	-	TAS	10747985
GO:0043208	glycosphingolipid binding	-	TAS	7680663
GO:0050839	cell adhesion molecule binding	-	IEA	-
GO:0070492	oligosaccharide binding	-	IMP	28011641

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007155	cell adhesion	-	TAS	10747985
GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	-	IMP	28011641
GO:0033198	response to ATP	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0050900	leukocyte migration	-	TAS	-
GO:0050901	leukocyte tethering or rolling	-	IMP	28011641

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IDA	2663882 28011641
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0030667	secretory granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04514	Cell adhesion molecules (CAMs)

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
15730554	Permissive nicotine regulation as a complement to traditional tobacco control. (2005 Feb 24)	Sumner W 2nd	BMC Public Health
23438328	Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma. (2013 Apr)	Fu JJ	OMICS