Gene: SELP

6403
CD62|CD62P|GMP140|GRMP|LECAM3|PADGEM|PSEL
selectin P
protein-coding
1q24.2
Ensembl:ENSG00000174175 MIM:173610 Vega:OTTHUMG00000034685 UniprotKB:P16109
NG_012125.1
PubMed
0   ANCO-SNPs
ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.587e-1 (AD)  9.119e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PKHD1L10.797
OR52I20.693
INMT0.683
SMR3B0.65
FGF70.649
STEAP40.647
COL8A10.63
C70.626
GDF30.59
DPPA20.579

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.323
HES6-0.313
HAGHL-0.311
BAIAP2L2-0.277
THAP8-0.27
KCNIP3-0.265
SPATA2L-0.264
LRFN4-0.258
CCDC85B-0.255
PACSIN3-0.254

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01109HeparinSmall Molecule9005-49-6Approved|InvestigationalTarget
DB03721N-acetyl-alpha-neuraminic acidSmall MoleculeExperimentalTarget
DB06779DalteparinSmall Molecule9005-49-6ApprovedTarget
DB08813NadroparinSmall Molecule9041-08-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SELP mRNA"22698814
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 results in decreased expression of SELP protein12087064
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]"18291361
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]"18291361
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"resveratrol promotes the reaction [1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]"18291361
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SELP mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SELP mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SELP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SELP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SELP mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SELP mRNA"25510870
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELP mRNA"19608276
C0284513,4,3',4'-tetrachlorobiphenyl"Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELP mRNA]"19608276
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SELP protein]"28973532
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased secretion of SELP protein"29216392
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SELP protein"28973532
D000079AcetaldehydeAcetaldehyde results in increased expression of SELP protein19036374
D000082AcetaminophenAcetaminophen affects the expression of SELP mRNA17562736
D000117Acetylglucosamine[Acetylglucosamine analog binds to Biotin] which binds to SELP protein12191509
D000117AcetylglucosamineAcetylglucosamine analog binds to SELP protein12191509
D000171AcroleinAcrolein results in increased expression of SELP mRNA17982132
D000171AcroleinAcrolein results in increased expression of SELP protein17982132
D000244Adenosine DiphosphateAdenosine Diphosphate results in increased expression of SELP protein23249183
D000244Adenosine Diphosphatecangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]18404433
D000244Adenosine DiphosphateCYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein]18394438
D000244Adenosine DiphosphateHeparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]9740346
D000244Adenosine Diphosphate"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]"18404433
D000244Adenosine Diphosphate"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]"18404433
D000244Adenosine DiphosphateP2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]18404433
D000244Adenosine DiphosphateQuercetin inhibits the reaction [Adenosine Diphosphate results in increased expression of SELP protein]23249183
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SELP gene27153756
D017311AmlodipineAmlodipine results in decreased expression of SELP protein15513305
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SELP mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SELP mRNA24449571
D016718Arachidonic AcidArachidonic Acid results in increased expression of SELP protein18413191|2324918
D016718Arachidonic AcidAspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]17543677|1841319
D016718Arachidonic AcidGlucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]]18413191
D016718Arachidonic AcidQuercetin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]23249183
C026987aroclor 1260[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in increased expression of SELP protein28163111
C006632arsenic trioxidearsenic trioxide results in decreased expression of SELP protein11775254|1620667
C006632arsenic trioxidearsenic trioxide results in increased expression of SELP mRNA22422340
C006632arsenic trioxideSodium Fluoride inhibits the reaction [arsenic trioxide results in increased expression of SELP mRNA]22422340
D001241AspirinAspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]17543677|1841319
D001241AspirinAspirin results in decreased expression of SELP protein15140583|1538105
D001241AspirinAspirin results in increased expression of SELP protein16756193
D001241AspirinGlucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]]18413191
D000068342Aspirin, Dipyridamole Drug Combination"Aspirin, Dipyridamole Drug Combination results in decreased expression of SELP protein"15381054
D001280AtrazineAtrazine results in increased expression of SELP mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SELP mRNA22300585
D004958EstradiolEstradiol inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein]19553526
D001710Biotin[Acetylglucosamine analog binds to Biotin] which binds to SELP protein12191509
C006780bisphenol Abisphenol A results in decreased expression of SELP mRNA26364221
C006780bisphenol Abisphenol A affects the expression of SELP mRNA25181051
C074619bivalirudinbivalirudin inhibits the reaction [F2 protein results in increased expression of SELP protein]16845256
C506830boldine methineboldine methine inhibits the reaction [AGT protein modified form results in increased expression of SELP protein]15944212
D019819Budesonide"Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELP mRNA]"15734790
D000001CalcimycinCalcimycin results in increased expression of SELP protein24466103
C117446cangrelorcangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]18404433
C117446cangrelor"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]"18404433
D002248Carbon MonoxideCarbon Monoxide results in increased expression of SELP protein modified form18629312
D002351CarrageenanCarrageenan results in increased expression of SELP protein11181422
D002351Carrageenanimisopasem manganese inhibits the reaction [Carrageenan results in increased expression of SELP protein]11181422
C016300chloramine-Tchloramine-T results in decreased expression of SELP protein11441983
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of SELP mRNA18636392
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of SELP protein"21574786
D002791Cholesterol, Dietary"resveratrol inhibits the reaction [Cholesterol, Dietary results in increased expression of SELP protein]"21574786
D002794Choline"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SELP protein]"28973532
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in increased expression of SELP protein28163111
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SELP protein28973532
C418118CI 1044CI 1044 results in increased expression of SELP mRNA17569694
D002927CimetidineCimetidine results in decreased expression of SELP protein17189874
C055162clopidogrelclopidogrel inhibits the reaction [F2 protein results in increased expression of SELP protein]17043144
C055162clopidogrelclopidogrel results in decreased expression of SELP mRNA19155974
C055162clopidogrelclopidogrel results in decreased expression of SELP protein19155974
C018021cobaltous chloridecobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of SELP protein]18635243|2129607
D003042CocaineCocaine affects the localization of SELP protein10814631|7689042
C028890convulxinconvulxin results in increased expression of SELP protein26482867
C028890convulxinresveratrol inhibits the reaction [convulxin results in increased expression of SELP protein]26482867
D003474CurcuminCurcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]18565277
D003474CurcuminCurcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]18565277
C038459curdlancurdlan results in decreased expression of SELP mRNA23543010
C036901defibrotidedefibrotide results in decreased expression of SELP protein9121223
D004008DiclofenacDiclofenac results in decreased expression of SELP protein14716214
D004008DiclofenacEnalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]14716214
D004041Dietary FatsDietary Fats results in increased expression of SELP mRNA25016146
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of SELP mRNA21852083
D019422Dietary SucroseDietary Sucrose results in increased expression of SELP mRNA26033743
C007488dinitrobenzenesulfonic acidALOX5 protein affects the reaction [dinitrobenzenesulfonic acid results in increased expression of SELP protein]15821759
C007488dinitrobenzenesulfonic aciddinitrobenzenesulfonic acid results in increased expression of SELP protein15821759
C007488dinitrobenzenesulfonic acidzileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of SELP protein]15821759
D004656EnalaprilEnalapril results in decreased expression of SELP mRNA25037058
D004656EnalaprilEnalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]14716214
D004967EstrogensEstradiol inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein]19553526
D004967EstrogensEstrogens deficiency results in increased expression of SELP protein19553526
D004967EstrogensLosartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein]19553526
D004970EstroneEstrone results in increased expression of SELP mRNA22903158
D000431EthanolEthanol results in decreased expression of SELP protein21574786
D009240N-Formylmethionine Leucyl-PhenylalanineALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
D009240N-Formylmethionine Leucyl-PhenylalanineForopafant inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
D009240N-Formylmethionine Leucyl-PhenylalanineITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
D009240N-Formylmethionine Leucyl-PhenylalanineMK-886 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
D009240N-Formylmethionine Leucyl-PhenylalanineN-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein11116075
D009240N-Formylmethionine Leucyl-PhenylalaninePTAFR protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
D009240N-Formylmethionine Leucyl-PhenylalanineSR 121566 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
D009240N-Formylmethionine Leucyl-Phenylalaninezileuton inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
C071317ForopafantForopafant inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
C071317ForopafantForopafant inhibits the reaction [Platelet Activating Factor results in increased expression of SELP protein]11116075
D019833GenisteinGenistein results in decreased expression of SELP mRNA21048042
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of SELP mRNA21782745
D005947GlucoseGlucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]]18413191
D005947Glucose[Glucose results in increased susceptibility to sodium arsenite] which results in increased expression of SELP protein28264687
D006493HeparinHeparin inhibits the reaction [F2 protein affects the localization of SELP protein]9740346
D006493HeparinHeparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]9740346
D006493HeparinHeparin results in increased expression of SELP protein10544909
D017313FenretinideFenretinide results in increased expression of SELP mRNA28973697
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein"11116075|1829136
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]"18291361
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]"18291361
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"ICI 192605 inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]"11116075
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]"18291361
D01979615-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid"resveratrol promotes the reaction [1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]"18291361
C057498ICI 192605"ICI 192605 inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]"11116075
C121876imisopasem manganeseimisopasem manganese inhibits the reaction [Carrageenan results in increased expression of SELP protein]11181422
D007213IndomethacinSELP protein affects the susceptibility to Indomethacin10486359
C008261lead acetatelead acetate results in increased expression of SELP mRNA20542052
C008288LipofundinLipofundin inhibits the reaction [Lipopolysaccharides results in increased expression of SELP protein]16804125
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of SELP protein"21664406
C440499lipopolysaccharide, Escherichia coli O111 B4"Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELP mRNA]"15734790
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELP mRNA"15734790
C440499lipopolysaccharide, Escherichia coli O111 B4"resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELP mRNA]"15734790
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SELP mRNA22135065
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SELP protein21135813
D008070LipopolysaccharidesNR1H4 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of SELP mRNA]22135065
D008070LipopolysaccharidesLipofundin inhibits the reaction [Lipopolysaccharides results in increased expression of SELP protein]16804125
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SELP mRNA22903158
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SELP protein16020654|1680412
C040527lipoxin A4SELP protein affects the susceptibility to lipoxin A47602232
D019808LosartanLosartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein]19553526
D017997Leukotriene C4Leukotriene C4 results in increased expression of SELP protein9152370
D017998Leukotriene D4Leukotriene D4 results in increased expression of SELP protein9152370
D008627Mercuric ChlorideMercuric Chloride affects the expression of SELP mRNA20353558
D008715Methionine"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SELP protein]"28973532
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] results in increased expression of SELP protein28163111
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SELP protein28973532
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of SELP mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of SELP mRNA21782745
C060893MK-886MK-886 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
C111914N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]"18404433
C111914N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate"N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]]"18404433
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SELP mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SELP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SELP"19698757
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SELP mRNA"25554681
D000068577NebivololNebivolol results in decreased expression of SELP mRNA17310107
D009532NickelNickel affects the expression of SELP mRNA14575637
D009532NickelNickel results in increased expression of SELP mRNA25583101
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of SELP mRNA]14575637
C029938nickel sulfatenickel sulfate results in increased expression of SELP mRNA16166746
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of SELP protein modified form18629312
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of SELP mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SELP mRNA27935865
C010722nylestriolnylestriol results in decreased expression of SELP protein12934402
C464660obeticholic acidNR1H4 gene mutant form inhibits the reaction [obeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]]22135065
C464660obeticholic acidobeticholic acid inhibits the reaction [TNF results in increased expression of SELP mRNA]22135065
D010081OxazoloneOxazolone results in increased expression of SELP mRNA21893156
D010100Oxygencobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of SELP protein]18635243|2129607
D010100OxygenOxygen deficiency results in increased expression of SELP protein18635243|2129607
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of SELP mRNA18636392
D017239PaclitaxelPaclitaxel results in increased expression of SELP mRNA18754875
C002669parthenolideparthenolide results in decreased expression of SELP mRNA16921510
D052638Particulate MatterParticulate Matter results in increased expression of SELP protein modified form18629312
D052638Particulate MatterParticulate Matter results in decreased expression of SELP mRNA23638009
D052638Particulate MatterParticulate Matter results in increased expression of SELP mRNA21708214
D052638Particulate MatterParticulate Matter results in increased expression of SELP protein23451061
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SELP mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SELP mRNA22269386
C005435phenylmethylpyrazolonephenylmethylpyrazolone results in decreased expression of SELP protein16041266
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of SELP mRNA27935865
C006253pirinixic acidpirinixic acid results in decreased expression of SELP mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of SELP mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of SELP mRNA16912651
D010972Platelet Activating FactorForopafant inhibits the reaction [Platelet Activating Factor results in increased expression of SELP protein]11116075
D010972Platelet Activating FactorPlatelet Activating Factor results in increased expression of SELP protein11116075
D017035PravastatinPravastatin results in decreased expression of SELP protein11189483
D011374ProgesteroneProgesterone results in decreased expression of SELP mRNA22903158
D011441PropylthiouracilPropylthiouracil results in decreased expression of SELP mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [Adenosine Diphosphate results in increased expression of SELP protein]23249183
D011794QuercetinQuercetin inhibits the reaction [Arachidonic Acid results in increased expression of SELP protein]23249183
D011794QuercetinQuercetin inhibits the reaction [F2 protein results in increased expression of SELP protein]14628445
D011794QuercetinQuercetin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein]20093625
D011794Quercetin"Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELP mRNA]"19608276
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SELP protein15964915
C059514resveratrol"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione promotes the reaction [resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]"18291361
C059514resveratrol"resveratrol inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]"18291361
C059514resveratrolresveratrol inhibits the reaction [convulxin results in increased expression of SELP protein]26482867
C059514resveratrolresveratrol inhibits the reaction [F2 protein results in increased expression of SELP protein]16051184
C059514resveratrol"resveratrol promotes the reaction [1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of SELP protein]]"18291361
C059514resveratrol"resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELP mRNA]"15734790
C059514resveratrol"resveratrol inhibits the reaction [Cholesterol, Dietary results in increased expression of SELP protein]"21574786
C059514resveratrolresveratrol results in decreased expression of SELP protein20709957
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of SELP mRNA21852083
C089730rosiglitazonerosiglitazone results in decreased expression of SELP mRNA18093596
C089730rosiglitazonerosiglitazone results in decreased expression of SELP mRNA17394460
D000068718Rosuvastatin CalciumRosuvastatin Calcium results in decreased expression of SELP mRNA15681303
C109135secoboldinesecoboldine inhibits the reaction [AGT protein modified form results in increased expression of SELP protein]15944212
D020280SertralineSertraline results in decreased expression of SELP protein12912814|1593281
D012822Silicon DioxideSilicon Dioxide results in increased expression of SELP mRNA23221170
D019821SimvastatinSimvastatin inhibits the reaction [staphylococcal alpha-toxin results in increased expression of SELP protein]12379581
D019821SimvastatinSimvastatin results in decreased expression of SELP mRNA16414398
D020123SirolimusSirolimus inhibits the reaction [Zymosan analog results in increased expression of SELP protein]16797888
C009277sodium arsenatesodium arsenate results in decreased expression of SELP mRNA23922661
C009277sodium arsenatesodium arsenate results in increased expression of SELP mRNA21795629
C017947sodium arsenite[Glucose results in increased susceptibility to sodium arsenite] which results in increased expression of SELP protein28264687
D012969Sodium FluorideSodium Fluoride inhibits the reaction [arsenic trioxide results in increased expression of SELP mRNA]22422340
D012969Sodium FluorideSodium Fluoride results in increased expression of SELP mRNA22422340
D053260SootSoot results in increased expression of SELP mRNA22461453|2655175
C106774SR 121566SR 121566 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
C021091staphylococcal alpha-toxinSimvastatin inhibits the reaction [staphylococcal alpha-toxin results in increased expression of SELP protein]12379581
C021091staphylococcal alpha-toxinstaphylococcal alpha-toxin results in increased expression of SELP protein12379581
C049411stephenanthrinestephenanthrine inhibits the reaction [AGT protein modified form results in increased expression of SELP protein]14559857
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of SELP mRNA16214533
C024075styrofoamstyrofoam results in increased expression of SELP protein21123846
D013739TestosteroneTestosterone results in decreased expression of SELP mRNA22903158
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SELP mRNA20055451
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SELP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of SELP mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SELP mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SELP mRNA27562557
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of SELP protein16797888
C056068theaflavintheaflavin inhibits the reaction [APOE gene mutant form results in increased expression of SELP protein]20093625
D013917ThrombinThrombin results in increased expression of SELP21034320
C009495titanium dioxidetitanium dioxide results in increased expression of SELP protein22352400
C009495titanium dioxidetitanium dioxide results in decreased expression of SELP mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SELP mRNA20133372
C479163tofacitinibtofacitinib results in decreased expression of SELP mRNA22899318
D014118Toxins, Biological"Toxins, Biological affects the expression of SELP mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of SELP protein11775254|1620667
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of SELP mRNA]14575637
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SELP mRNA19042947
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SELP mRNA21893156
C488565uvariopsineuvariopsine inhibits the reaction [AGT protein modified form results in increased expression of SELP protein]14559857
D014635Valproic AcidValproic Acid results in decreased methylation of SELP gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased expression of SELP14738208
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SELP gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SELP mRNA27935865
C063449zileutonzileuton inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]11116075
C063449zileutonzileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of SELP protein]15821759
D015054ZymosanALOX5 protein affects the reaction [Zymosan results in increased expression of SELP protein]15241586
D015054ZymosanZymosan results in increased expression of SELP protein15241586
D015054ZymosanSirolimus inhibits the reaction [Zymosan analog results in increased expression of SELP protein]16797888
D015054ZymosanZymosan analog results in increased expression of SELP protein16797888

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IMP16514062  
GO:0005509calcium ion binding-IDA11081633  
GO:0005515protein binding-IPI9129046  11081633  11237770  15633604  18606703  19118202  
26627825  28011641  
GO:0008201heparin binding-IDA7680663  
GO:0033691sialic acid binding-IDA7680663  
GO:0042806fucose binding-IDA7680663  
GO:0043208glycosphingolipid binding-TAS7680663  
GO:0048306calcium-dependent protein binding-IEA-  
GO:0070492oligosaccharide binding-IDA7680663  11081633  28011641  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0002687positive regulation of leukocyte migration-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0007155cell adhesion-TAS2466574  
GO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-IEA-  
GO:0007159leukocyte cell-cell adhesion-IDA7680663  
GO:0010572positive regulation of platelet activation-ISS16514062  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA17632516  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IMP28011641  
GO:0032496response to lipopolysaccharide-IC16514062  
GO:0033623regulation of integrin activation-IMP17632516  
GO:0035584calcium-mediated signaling using intracellular calcium source-IGI15879141  
GO:0050829defense response to Gram-negative bacterium-IC16514062  
GO:0050900leukocyte migration-TAS-  
GO:0050901leukocyte tethering or rolling-IMP28011641  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA9290466  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA28011641  
GO:0009897external side of plasma membrane-IDA16514062  
GO:0031088platelet dense granule membrane-TAS-  
GO:0031092platelet alpha granule membrane-IDA15297306  
GO:0031092platelet alpha granule membrane-TAS-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa05144Malaria
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17944986Clinical and genetic correlates of soluble P-selectin in the community. (2008 Jan)Lee DSJ Thromb Haemost
25185791Gender-specific distribution of selenium to serum selenoproteins: associations with total selenium levels, age, smoking, body mass index, and physical activity. (2014 Sep-Oct)Letsiou SBiofactors
23897225Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis. (2013 Nov)Assassi SArthritis Rheum
27334433Protective Action of Se-Supplement Against Acute Alcoholism Is Regulated by Selenoprotein P (SelP) in the Liver. (2017 Feb)Zhang ZBiol Trace Elem Res
28190280Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study. (2017 Mar)Gharipour MJ Gene Med
17634906Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach. (2007 Nov)Barbaux SJ Mol Med (Berl)
18535285Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-African young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. (2008 Aug)Reiner APArterioscler Thromb Vasc Biol