Gene info: ID 64065

Gene: PERP

GENE ID: 64065

Synonyms: KCP1|KRTCAP1|PIGPC1|THW|dJ496H19.1

Description: PERP, TP53 apoptosis effector

Gene type: protein-coding

Location: 6q23.3

dbXrefs: Ensembl:ENSG00000112378 MIM:609301 Vega:OTTHUMG00000015668 UniprotKB:Q96FX8

RefSeq: NC_000006.12

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : 6.870e-2 (AD) 6.912e-1 (ND) (Frontal_Cortex)

Pascal p-value : 3.848e-1 (AD) 1.527e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2484066	chr6:138095981 (GRCh38.p7)	T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2506843	chr6:138095943 (GRCh38.p7)	C>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MECOM	0.843
ELOVL7	0.841
GNG11	0.84
CYYR1	0.835
ITGA1	0.83
TGFBR2	0.828
FLI1	0.817
CFH	0.815
SLC19A3	0.814
CFI	0.812

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EXTL1	-0.492
BCL11A	-0.492
NEUROD6	-0.49
LRTM2	-0.488
SLC7A4	-0.486
MARCH4	-0.484
SPRN	-0.478
LRFN2	-0.475
KCNIP3	-0.472
ABCC12	-0.47

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of PERP mRNA	25088246
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PERP mRNA	16788091
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of PERP mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C477187	5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole	"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of PERP mRNA"	22745752
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of PERP mRNA	25704631\|2669055
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PERP gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PERP mRNA	21641981
C077990	alvocidib	alvocidib results in increased expression of PERP mRNA	21382384
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PERP mRNA	24449571
C015001	arsenite	arsenite results in decreased expression of PERP mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of PERP mRNA]	18929588
D001507	Beclomethasone	Beclomethasone results in increased expression of PERP mRNA	23656298
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of PERP mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PERP mRNA	20064835\|2231617
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PERP mRNA	19770486\|2171566
D004958	Estradiol	Estradiol affects the expression of PERP mRNA	22574217
D004958	Estradiol	Estradiol results in increased expression of PERP mRNA	19484750
C006780	bisphenol A	bisphenol A affects the expression of PERP mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PERP gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of PERP mRNA	21382384
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PERP mRNA	23650126
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of PERP mRNA	26272509
C100187	chloropicrin	chloropicrin results in increased expression of PERP mRNA	26352163
D002857	Chromium	Chromium results in increased expression of PERP mRNA	21437242
D003035	Cobalt	[tungsten carbide co-treated with Cobalt] results in increased expression of PERP mRNA	18078969
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PERP mRNA	19549813
D003375	Coumestrol	Coumestrol results in decreased expression of PERP mRNA	19167446
D016572	Cyclosporine	Cyclosporine results in increased methylation of PERP promoter	27989131
D013759	Dronabinol	Dronabinol results in increased expression of PERP mRNA	12237329
D003976	Diazinon	Diazinon affects the expression of PERP mRNA	22546817
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of PERP mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PERP mRNA	24280081\|2739243
D002945	Cisplatin	Cisplatin results in increased expression of PERP mRNA	21382384\|2428008
D004041	Dietary Fats	Dietary Fats results in increased expression of PERP mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in decreased expression of PERP mRNA	21852083
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PERP mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PERP mRNA]	17854601
D004317	Doxorubicin	Doxorubicin results in increased expression of PERP mRNA	16243910\|2138238
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PERP mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PERP mRNA	17557909
D005047	Etoposide	Etoposide results in increased expression of PERP mRNA	21382384\|2527062
D018120	Finasteride	Finasteride results in increased expression of PERP mRNA	24136188
D015073	2-Acetylaminofluorene	TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PERP mRNA]	17317680
D005485	Flutamide	Flutamide results in decreased expression of PERP mRNA	19442681
D005485	Flutamide	Flutamide results in increased expression of PERP mRNA	24136188
D005897	Glafenine	Glafenine results in decreased expression of PERP mRNA	24136188
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of PERP mRNA	22634610
D017313	Fenretinide	Fenretinide results in decreased expression of PERP mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of PERP mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PERP mRNA	21382384
D006918	Hydroxyurea	Hydroxyurea results in increased expression of PERP mRNA	27208086
D007052	Ibuprofen	Ibuprofen results in decreased expression of PERP mRNA	28201806
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of PERP mRNA	27392435
C045463	leflunomide	leflunomide results in increased expression of PERP mRNA	24136188
C042720	mercuric bromide	mercuric bromide results in increased expression of PERP mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
D008727	Methotrexate	Methotrexate results in increased expression of PERP mRNA	21678067
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PERP mRNA	23179753\|2718838
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PERP mRNA	21382384
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of PERP mRNA	21382384\|2527062
D016685	Mitomycin	Mitomycin results in increased expression of PERP mRNA	21382384
C523799	MRK 003	MRK 003 results in decreased expression of PERP mRNA	21169257
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PERP mRNA"	25554681
C029938	nickel sulfate	nickel sulfate results in increased expression of PERP mRNA	22714537
C482205	nutlin 3	nutlin 3 results in increased expression of PERP mRNA	16949053
D017239	Paclitaxel	Paclitaxel results in increased expression of PERP mRNA	18058816
D000073878	Palm Oil	Palm Oil results in increased expression of PERP mRNA	18042831
D010634	Phenobarbital	Phenobarbital affects the expression of PERP mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PERP mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of PERP mRNA	18301758\|2381119
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of PERP mRNA	22714537
D011441	Propylthiouracil	Propylthiouracil results in increased expression of PERP mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of PERP mRNA	27029645
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of PERP mRNA"	21152443
D011794	Quercetin	Quercetin results in increased expression of PERP mRNA	21632981
C059514	resveratrol	resveratrol results in increased expression of PERP mRNA	15767336
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PERP mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PERP mRNA	16214954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PERP mRNA	17035482\|1879615
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PERP mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PERP mRNA	18796159\|2121527
C009495	titanium dioxide	titanium dioxide results in decreased expression of PERP mRNA	23557971
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of PERP mRNA	24935251\|2627250
C080163	trovafloxacin	trovafloxacin results in decreased expression of PERP mRNA	24136188
C002802	tungsten carbide	[tungsten carbide co-treated with Cobalt] results in increased expression of PERP mRNA	18078969
D014520	Urethane	Urethane results in increased expression of PERP mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of PERP mRNA	15885361
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PERP mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PERP mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of PERP gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PERP mRNA	23179753\|2438349
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of PERP mRNA	21382384
C070417	Win 55212-2	Win 55212-2 results in increased expression of PERP mRNA	12237329

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002934	desmosome organization	-	IBA	21873635
GO:0007219	Notch signaling pathway	-	IEA	-
GO:0034113	heterotypic cell-cell adhesion	-	IEA	-
GO:0042981	regulation of apoptotic process	-	TAS	-
GO:0045862	positive regulation of proteolysis	-	IDA	18387192
GO:0070268	cornification	-	TAS	-
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	-	IEA	-
GO:0097186	amelogenesis	-	IEA	-
GO:0097202	activation of cysteine-type endopeptidase activity	-	IDA	18387192

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IEA	-
GO:0005794	Golgi apparatus	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IEA	-
GO:0030054	cell junction	-	IBA	21873635
GO:0030057	desmosome	-	IEA	-

KEGG ID	KEGG Term
hsa04115	p53 signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	TAS
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	TAS
R-HSA-6805567	Keratinization	TAS
R-HSA-6809371	Formation of the cornified envelope	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21212151	Interactions between genetic polymorphisms in the apoptotic pathway and environmental factors on esophageal adenocarcinoma risk. (2011 Apr)	Wu IC	Carcinogenesis