Gene: NPAS3

64067
MOP6|PASD6|bHLHe12
neuronal PAS domain protein 3
protein-coding
14q13.1
Ensembl:ENSG00000151322 MIM:609430 Vega:OTTHUMG00000140215 UniprotKB:Q8IXF0
NG_013036.1
SNP Mapped
4   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.980e-1 (AD)  4.364e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17571355chr14:33400670 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17101003chr14:33399174 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10483422chr14:33009299 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs12586198chr14:32972410 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BMPR1B0.928
METTL7A0.915
TP53BP20.914
PBXIP10.908
SOX90.906
AGT0.902
STK330.9
GJA10.893
STON20.891
PON20.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGMAT-0.484
MCHR1-0.474
TYRP1-0.461
OSBPL10-0.461
CALHM1-0.46
TRABD2A-0.458
CACNA1F-0.454
DUSP27-0.453
THEM5-0.452
IL12RB2-0.451

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NPAS3 mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPAS3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPAS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPAS3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPAS3 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of NPAS3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPAS3 gene27153756
D0150571-NaphthylamineNPAS3 gene SNP affects the susceptibility to 1-Naphthylamine25622337
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NPAS3 mRNA20713471
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NPAS3 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of NPAS3 mRNA19167446|1961957
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NPAS3 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NPAS3 mRNA26496021
C054133casticincasticin results in decreased expression of NPAS3 mRNA28444820
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NPAS3 gene20938992
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NPAS3 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of NPAS3 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of NPAS3 mRNA19167446
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NPAS3 gene20938992
D019833GenisteinGenistein results in decreased expression of NPAS3 mRNA26865667
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NPAS3 mRNA17183730
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NPAS3 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of NPAS3 mRNA23179753
C028007nickel monoxidenickel monoxide results in decreased expression of NPAS3 mRNA19167457
D009538NicotineNicotine results in decreased expression of NPAS3 mRNA23825647
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPAS3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of NPAS3 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of NPAS3 mRNA23557933
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of NPAS3 mRNA19167446
C116926rofecoxibrofecoxib results in increased expression of NPAS3 mRNA17070997
D012834SilverSilver results in decreased expression of NPAS3 mRNA26551752
D012834SilverSilver results in decreased expression of NPAS3 mRNA27131904
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of NPAS3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPAS3 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPAS3 mRNA21570461
D013849ThimerosalThimerosal results in increased expression of NPAS3 mRNA24675092
C009495titanium dioxidetitanium dioxide results in decreased expression of NPAS3 mRNA23557971
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NPAS3 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPAS3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of NPAS3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of NPAS3 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased methylation of NPAS3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NPAS3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003677DNA binding-IEA-  
GO:0046982protein heterodimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal