Gene: LHPP

64077
HDHD2B
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
protein-coding
10q26.13
Ensembl:ENSG00000107902 MIM:617231 Vega:OTTHUMG00000019214 UniprotKB:Q9H008
NC_000010.11
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.873e-1 (AD)  8.700e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17152064chr10:124579190 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs34997829chr10:124546821 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18593374chr10:126302546LHPP3'UTR9.235e-4Alcohol use disorders26763658
cg24759108chr10:126223401LHPP6.300e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAQR60.907
PLEKHB10.903
SEPT40.896
FBXW40.882
CENPB0.88
MID1IP10.88
TPPP30.871
MCM70.865
MARCKSL10.861
FOXO40.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.488
OR4F5-0.435
HS6ST3-0.43
HRH2-0.427
PRSS12-0.426
KCNH5-0.41
MED12L-0.406
CNTN5-0.404
MTUS2-0.401
NCR3LG1-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LHPP mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl affects the expression of LHPP mRNA"20702594
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LHPP protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LHPP mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LHPP mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LHPP mRNA20106945|2187194
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LHPP mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LHPP mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of LHPP mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LHPP mRNA28628672
C006780bisphenol Abisphenol A affects the expression of LHPP mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of LHPP mRNA26079696
C584509C646 compoundC646 compound results in increased expression of LHPP mRNA26191083
D002104CadmiumCadmium results in increased expression of LHPP mRNA24376830
C018021cobaltous chloridecobaltous chloride results in decreased expression of LHPP mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of LHPP mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of LHPP mRNA19770486
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of LHPP mRNA28659758
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LHPP mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LHPP mRNA21266533
D002945CisplatinCisplatin results in decreased expression of LHPP mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of LHPP mRNA24535843
D000431EthanolEthanol results in increased expression of LHPP mRNA19167417
D005485FlutamideFlutamide results in decreased expression of LHPP mRNA24793618
D005897GlafenineGlafenine results in decreased expression of LHPP mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of LHPP mRNA20044591
C492448ICG 001ICG 001 results in increased expression of LHPP mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LHPP mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of LHPP mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of LHPP mRNA28628672
C544151jinfukangjinfukang results in increased expression of LHPP mRNA27392435
D007854LeadLead affects the splicing of LHPP mRNA28903495
D015741MetriboloneMetribolone affects the splicing of LHPP mRNA17010196
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of LHPP mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of LHPP mRNA21195148
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of LHPP promoter18448484
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LHPP mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LHPP mRNA"25554681|2562005
C012655nimesulidenimesulide results in decreased expression of LHPP mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of LHPP mRNA17616710
D010098OxycodoneOxycodone results in increased expression of LHPP mRNA23439660
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of LHPP protein26168851
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of LHPP mRNA28659758
D010634PhenobarbitalPhenobarbital affects the expression of LHPP mRNA23091169
D011374ProgesteroneProgesterone results in decreased expression of LHPP mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of LHPP mRNA21278054
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of LHPP mRNA28659758
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LHPP mRNA25895662
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of LHPP promoter18448484
C016104sodium bichromatesodium bichromate results in decreased expression of LHPP mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LHPP mRNA20702594
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LHPP mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LHPP mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LHPP mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of LHPP mRNA28973375
D013853ThioacetamideThioacetamide results in decreased expression of LHPP mRNA23411599
C057693troglitazonetroglitazone results in increased expression of LHPP mRNA28973697
C406224valdecoxibvaldecoxib results in decreased expression of LHPP mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of LHPP mRNA25979313
C025643vinclozolinvinclozolin results in decreased expression of LHPP mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-ISS-  
GO:0004427inorganic diphosphatase activity-IBA21873635  
GO:0004427inorganic diphosphatase activity-IDA12801912  
GO:0004427inorganic diphosphatase activity-TAS-  
GO:0016791phosphatase activity-IBA21873635  
GO:0042803protein homodimerization activity-IPI12801912  
GO:0101006protein histidine phosphatase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IBA21873635  
GO:0006470protein dephosphorylation-ISS-  
GO:0006796phosphate-containing compound metabolic process-IDA12801912  
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TAS-  
GO:0016311dephosphorylation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16430861  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA16430861  
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-73817Purine ribonucleoside monophosphate biosynthesisTAS
R-HSA-8956320Nucleobase biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27531626The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. (2017 Feb)Polimanti RNeuropsychopharmacology