Gene: SLC28A3

64078
CNT3
solute carrier family 28 member 3
protein-coding
9q21.32-q21.33
Ensembl:ENSG00000197506 MIM:608269 Vega:OTTHUMG00000020117 UniprotKB:Q9HAS3
NC_000009.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.989e-1 (AD)  4.361e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17343066chr9:84331158 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf870.601
NSUN70.591
CEACAM40.581
CD300E0.573
FPR20.572
C1orf1580.569
LILRB20.563
TREML20.561
ABCA130.556
CHODL0.543

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.427
CHRNA4-0.393
MPPED1-0.391
EXTL1-0.389
PVALB-0.383
GNG13-0.383
TMEM151B-0.378
SOHLH1-0.372
TMEM155-0.367
SLC30A3-0.365

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00242CladribineSmall Molecule4291-63-8Approved|InvestigationalTransporter
DB00441GemcitabineSmall Molecule95058-81-4ApprovedTransporter
DB00640AdenosineSmall Molecule58-61-7Approved|InvestigationalTransporter
DB00811RibavirinSmall Molecule36791-04-5ApprovedTransporter
DB01033MercaptopurineSmall Molecule50-44-2ApprovedTransporter
DB01073FludarabineSmall Molecule21679-14-1ApprovedTransporter
DB04335InosineSmall Molecule58-63-9Approved|InvestigationalTransporter
DB04485DeoxythymidineSmall Molecule50-89-5Experimental|InvestigationalTransporter
DB09327Tegafur-uracilSmall Molecule74578-38-4Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC28A3 mRNA"22698814
C4879483-iodothyronamineSLC28A3 mRNA affects the uptake of 3-iodothyronamine19074582
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC28A3 mRNA"18648102
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC28A3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of SLC28A3 mRNA19128835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC28A3 mRNA20064835
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SLC28A3 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SLC28A3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SLC28A3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC28A3 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of SLC28A3 promoter22457795
D002784CholesterolCholesterol results in increased expression of SLC28A3 mRNA26296894
D002994ClofibrateClofibrate results in decreased expression of SLC28A3 mRNA22300585
C007556domiphenSLC28A3 gene SNP affects the susceptibility to domiphen25622337
C069837fullerene C60fullerene C60 results in decreased expression of SLC28A3 mRNA19167457
C039281furanfuran results in increased methylation of SLC28A3 gene22079235
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC28A3 mRNA26752646
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC28A3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC28A3 mRNA"25554681
D010126OzoneOzone results in increased expression of SLC28A3 mRNA17095637
C006253pirinixic acidpirinixic acid results in increased expression of SLC28A3 mRNA20813756
C009495titanium dioxidetitanium dioxide results in decreased expression of SLC28A3 mRNA23557971
D015215ZidovudineZidovudine results in increased expression of SLC28A3 mRNA24292225
C088658zoledronic acidzoledronic acid results in increased expression of SLC28A3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005337nucleoside transmembrane transporter activity-IBA21873635  
GO:0005415nucleoside:sodium symporter activity-IBA21873635  
GO:0005415nucleoside:sodium symporter activity-TAS-  
GO:0015389pyrimidine- and adenine-specific:sodium symporter activity-IBA21873635  
GO:0015390purine-specific nucleoside:sodium symporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0015855pyrimidine nucleobase transport-IEA-  
GO:0015860purine nucleoside transmembrane transport-IBA21873635  
GO:0015860purine nucleoside transmembrane transport-IEA-  
GO:0015864pyrimidine nucleoside transport-IBA21873635  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0072531pyrimidine-containing compound transmembrane transport-IEA-  
GO:1901642nucleoside transmembrane transport-IBA21873635  
GO:1904823purine nucleobase transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-83936Transport of nucleosides and free purine and pyrimidine bases across the plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25505599Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects. (2014 Aug)Berg TPharmacol Res Perspect