Gene: GOLPH3

64083
GOPP1|GPP34|MIDAS|Vps74
golgi phosphoprotein 3
protein-coding
5p13.3
Ensembl:ENSG00000113384 MIM:612207 Vega:OTTHUMG00000090679 UniprotKB:Q9H4A6
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.535e-1 (AD)  2.772e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE2D30.935
SDCBP0.928
CAP10.926
ARF40.923
TMED20.922
RAB100.921
UBE2A0.92
HNRNPK0.919
CRK0.917
DEGS10.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.819
OR4F29-0.782
TCL1A-0.161
OR6C74-0.133
IL25-0.132
RNASE8-0.129
HMHB1-0.127
TNFRSF13B-0.123
TSPY2-0.121
SPRR2D-0.117

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GOLPH3 mRNA"19114083
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to GOLPH3 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GOLPH3 protein]26598702
D000082AcetaminophenAcetaminophen results in decreased expression of GOLPH3 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of GOLPH3 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GOLPH3 mRNA16483693
D001151ArsenicArsenic affects the methylation of GOLPH3 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GOLPH3 protein]26598702
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GOLPH3 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of GOLPH3 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GOLPH3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of GOLPH3 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of GOLPH3 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GOLPH3 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of GOLPH3 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of GOLPH3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GOLPH3 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GOLPH3 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GOLPH3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GOLPH3 mRNA21266533
D004147DioxinsDioxins affects the expression of GOLPH3 mRNA20463971
C100264enniatinsenniatins results in decreased expression of GOLPH3 mRNA27163883
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GOLPH3 protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GOLPH3 mRNA17942748
D005485FlutamideFlutamide results in increased expression of GOLPH3 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GOLPH3 gene20938992
C039281furanfuran results in increased methylation of GOLPH3 gene22079235
D005839GentamicinsGentamicins results in decreased expression of GOLPH3 mRNA22061828
D008694MethamphetamineMethamphetamine results in increased expression of GOLPH3 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GOLPH3 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GOLPH3 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of GOLPH3 mRNA29191790
C051752nefazodonenefazodone results in increased expression of GOLPH3 mRNA24136188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GOLPH3 protein26879310
D010634PhenobarbitalPhenobarbital results in decreased expression of GOLPH3 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of GOLPH3 mRNA19270015
C006253pirinixic acidpirinixic acid results in decreased expression of GOLPH3 mRNA16940010
D012822Silicon DioxideSilicon Dioxide results in increased expression of GOLPH3 mRNA22431001
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GOLPH3 mRNA17942748
C009495titanium dioxidetitanium dioxide results in increased expression of GOLPH3 mRNA27760801
D014415TunicamycinTunicamycin results in increased expression of GOLPH3 mRNA17127020
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GOLPH3 gene25560391
C025643vinclozolinvinclozolin affects the expression of GOLPH3 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of GOLPH3 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19553991  19837035  22190034  23027862  24485452  25416956  
GO:0019899enzyme binding-IPI23027862  
GO:0070273phosphatidylinositol-4-phosphate binding-IBA21873635  
GO:0070273phosphatidylinositol-4-phosphate binding-IDA19837035  23345592  
GO ID GO Term Qualifier Evidence PubMed
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-IBA21873635  
GO:0007030Golgi organization-IBA21873635  
GO:0007030Golgi organization-IMP19837035  23345592  
GO:0008283cell proliferation-IMP19553991  
GO:0009101glycoprotein biosynthetic process-IMP23027862  
GO:0009306protein secretion-IMP23500462  
GO:0010467gene expression-IMP23500462  
GO:0010821regulation of mitochondrion organization-IDA16263763  
GO:0016477cell migration-IMP23500462  
GO:0030032lamellipodium assembly-IMP23500462  
GO:0032008positive regulation of TOR signaling-IMP19553991  
GO:0043001Golgi to plasma membrane protein transport-IBA21873635  
GO:0043001Golgi to plasma membrane protein transport-IMP19837035  
GO:0043066negative regulation of apoptotic process-IMP24485452  
GO:0045053protein retention in Golgi apparatus-IMP23027862  
GO:0048194Golgi vesicle budding-IBA21873635  
GO:0048194Golgi vesicle budding-IMP19837035  
GO:0050714positive regulation of protein secretion-IMP23345592  
GO:0050901leukocyte tethering or rolling-IMP23027862  
GO:0060352cell adhesion molecule production-IMP23027862  
GO:0090161Golgi ribbon formation-IMP19837035  
GO:0090164asymmetric Golgi ribbon formation-IMP19837035  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA16263763  
GO:0005758mitochondrial intermembrane space-IEA-  
GO:0005768endosome-IEA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005794Golgi apparatus-IMP18410729  
GO:0005802trans-Golgi network-IBA21873635  
GO:0005802trans-Golgi network-IDA16263763  19553991  19837035  23027862  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA16263763  
GO:0005886plasma membrane-IEA-  
GO:0031985Golgi cisterna-IBA21873635  
GO:0031985Golgi cisterna-IDA23027862  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27611309Cigarette Smoking Condensate Disrupts Endoplasmic Reticulum-Golgi Network Homeostasis Through GOLPH3 Expression in Normal Lung Epithelial Cells. (2016 Sep)Yu KNNicotine Tob Res