Gene: SAMSN1

64092
HACS1|NASH1|SASH2|SH3D6B|SLy2
SAM domain, SH3 domain and nuclear localization signals 1
protein-coding
21q11.2
Ensembl:ENSG00000155307 MIM:607978 Vega:OTTHUMG00000074317 UniprotKB:Q9NSI8
NC_000021.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.605e-1 (AD)  1.566e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs760347chr21:14568068 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A70.931
CMTM70.926
CCR10.925
SASH30.925
PIK3AP10.923
TLR10.922
LAIR10.921
PTPRC0.918
C3AR10.918
HAVCR20.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.474
WNT7A-0.456
TMEM179-0.452
ATP2C2-0.448
ZNF835-0.438
MARCH4-0.434
KCNK4-0.433
EXTL1-0.428
BDH1-0.425
SPRN-0.419

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SAMSN1 mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of SAMSN1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SAMSN1 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of SAMSN1 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SAMSN1 mRNA24449571
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SAMSN1 mRNA]22228805
C006780bisphenol Abisphenol A results in decreased expression of SAMSN1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SAMSN1 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of SAMSN1 mRNA25979313
D002737ChloropreneChloroprene results in increased expression of SAMSN1 mRNA23125180
D003703DemecolcineDemecolcine results in increased expression of SAMSN1 mRNA23649840
D002945CisplatinCisplatin results in increased expression of SAMSN1 mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SAMSN1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of SAMSN1 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of SAMSN1 mRNA26485663
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SAMSN1 mRNA17942748
D005419FlavonoidsFlavonoids results in decreased expression of SAMSN1 mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of SAMSN1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SAMSN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SAMSN1 mRNA"25554681
D009532NickelNickel results in increased expression of SAMSN1 mRNA23195993|2558310
C029938nickel sulfatenickel sulfate results in increased expression of SAMSN1 mRNA16780908
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SAMSN1 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SAMSN1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of SAMSN1 mRNA20880076
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SAMSN1 mRNA27153767
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SAMSN1 mRNA22698814
D015474IsotretinoinIsotretinoin results in increased expression of SAMSN1 mRNA20436886
D012822Silicon DioxideSilicon Dioxide results in increased expression of SAMSN1 mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SAMSN1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SAMSN1 mRNA17942748
C009495titanium dioxidetitanium dioxide results in increased expression of SAMSN1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SAMSN1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SAMSN1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SAMSN1 mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SAMSN1 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of SAMSN1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SAMSN1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SAMSN1 mRNA23034163
D014750VincristineVincristine results in increased expression of SAMSN1 mRNA23649840
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SAMSN1 mRNA27935865
D015032ZincZinc deficiency results in increased expression of SAMSN1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IBA21873635  
GO:0001784phosphotyrosine residue binding-IDA15381729  
GO:0003723RNA binding-HDA22658674  
GO ID GO Term Qualifier Evidence PubMed
GO:0002820negative regulation of adaptive immune response-ISS-  
GO:0009966regulation of signal transduction-IBA21873635  
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation-IBA21873635  
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation-ISS-  
GO:0050869negative regulation of B cell activation-IBA21873635  
GO:0050869negative regulation of B cell activation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11594764  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal