Gene: SMOC2

64094
DTDP1|MST117|MSTP117|MSTP140|SMAP2|bA270C4A.1|bA37D8.1|dJ421D16.1
SPARC related modular calcium binding 2
protein-coding
6q27
Ensembl:ENSG00000112562 MIM:607223 Vega:OTTHUMG00000016050 UniprotKB:Q9H3U7
NG_032781.1
PubMed
0   ANCO-SNPs
ND
1   
8.204e-1 (AD)  5.520e-2 (ND)   (Frontal_Cortex)
1.907e-1 (AD)  1.097e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01568319chr6:168841907SMOC26.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EBF10.706
COL1A20.703
COL6A20.694
PDE5A0.661
MYL90.658
OLFML10.65
NTN10.649
DCN0.64
COL1A10.633
SLC22A30.632

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYGD-0.407
GPR150-0.405
EIF4E1B-0.4
VSTM5-0.395
RHEBL1-0.392
SLC17A6-0.388
KHDC1-0.387
C3orf80-0.385
HTR5A-0.384
GFRA2-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SMOC2 mRNA"27291303
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of SMOC2 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of SMOC2 mRNA]"19414516
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SMOC2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
D020106AcrylamideAcrylamide affects the expression of SMOC2 mRNA28959563
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of SMOC2 mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SMOC2 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SMOC2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMOC2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SMOC2 mRNA19146932
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SMOC2 mRNA21964900
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of SMOC2 mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SMOC2 mRNA20660070
D004958EstradiolEstradiol results in increased expression of SMOC2 mRNA24758408
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SMOC2 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMOC2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of SMOC2 mRNA23798566
C006780bisphenol Abisphenol A affects the expression of SMOC2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SMOC2 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMOC2 mRNA28628672
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SMOC2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SMOC2 mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SMOC2 mRNA20938992
C031180chrysenechrysene results in increased expression of SMOC2 mRNA26377693
D019327Copper SulfateCopper Sulfate results in increased expression of SMOC2 mRNA19549813
C057862cyanoginosin LRcyanoginosin LR results in increased expression of SMOC2 mRNA17654400
D016572CyclosporineCyclosporine results in increased expression of SMOC2 mRNA19770486
D003561CytarabineCytarabine results in decreased expression of SMOC2 mRNA21198554
D003907DexamethasoneDexamethasone results in increased expression of SMOC2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SMOC2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMOC2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMOC2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SMOC2 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of SMOC2 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of SMOC2 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SMOC2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of SMOC2 mRNA24880025
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of SMOC2 mRNA17490981
D004041Dietary FatsDietary Fats affects the expression of SMOC2 mRNA19680557
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SMOC2 mRNA17854601|2453584
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMOC2 mRNA]17854601
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SMOC2 mRNA28943392
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of SMOC2 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SMOC2 mRNA25380136
C118739entinostatentinostat results in increased expression of SMOC2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
D000431EthanolEthanol results in decreased expression of SMOC2 mRNA19167417
D005480FlurbiprofenFlurbiprofen results in decreased expression of SMOC2 mRNA16949054
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SMOC2 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of SMOC2 mRNA27664576
C039281furanfuran results in increased expression of SMOC2 mRNA24183702
C039281furanfuran results in increased expression of SMOC2 mRNA27387713
D005897GlafenineGlafenine results in increased expression of SMOC2 mRNA24136188
C004312glycidolglycidol results in decreased expression of SMOC2 mRNA24915197
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SMOC2 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SMOC2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMOC2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMOC2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SMOC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SMOC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMOC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SMOC2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SMOC2 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of SMOC2 mRNA20003209
D007649KetamineKetamine results in decreased expression of SMOC2 mRNA20080153
D015122MercaptopurineMercaptopurine results in decreased expression of SMOC2 mRNA23358152
C042720mercuric bromidemercuric bromide results in increased expression of SMOC2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SMOC2 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SMOC2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SMOC2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of SMOC2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SMOC2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SMOC2 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SMOC2 mRNA25380136
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SMOC2 mRNA25729387
D000073878Palm OilPalm Oil affects the expression of SMOC2 mRNA19680557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
D010656PhenylephrinePhenylephrine results in decreased expression of SMOC2 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SMOC2 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SMOC2 mRNA23811191
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SMOC2 mRNA22698814
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SMOC2 mRNA20660070
D011374ProgesteroneProgesterone affects the expression of SMOC2 mRNA17251523
D011374ProgesteroneProgesterone results in increased expression of SMOC2 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of SMOC2 mRNA24780913
C428725pyridabenpyridaben results in increased expression of SMOC2 mRNA22563483
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SMOC2 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of SMOC2 gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of SMOC2 mRNA22561333
C016104sodium bichromatesodium bichromate results in increased expression of SMOC2 mRNA22561333|2599309
D012969Sodium FluorideSodium Fluoride results in decreased expression of SMOC2 mRNA27257137
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of SMOC2 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMOC2 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SMOC2 mRNA19146932
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of SMOC2 mRNA28943392
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SMOC2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SMOC2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SMOC2 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of SMOC2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SMOC2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SMOC2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SMOC2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of SMOC2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SMOC2 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SMOC2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SMOC2 mRNA21126777
D024483Vitamin K 3Vitamin K 3 affects the expression of SMOC2 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of SMOC2 mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of SMOC2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-ISA12741954  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010595positive regulation of endothelial cell migration-IDA16774925  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0030198extracellular matrix organization-IEA-  
GO:0035470positive regulation of vascular wound healing-IDA16774925  
GO:0045766positive regulation of angiogenesis-IDA16774925  
GO:0045766positive regulation of angiogenesis-IGI16774925  
GO:0045931positive regulation of mitotic cell cycle-IDA16774925  
GO:1900748positive regulation of vascular endothelial growth factor signaling pathway-IDA16774925  
GO:2000573positive regulation of DNA biosynthetic process-IDA16774925  
GO:2000573positive regulation of DNA biosynthetic process-IGI16774925  
GO:2001028positive regulation of endothelial cell chemotaxis-IGI16774925  
GO ID GO Term Qualifier Evidence PubMed
GO:0005604basement membrane-IEA-  
GO:0005614interstitial matrix-IEA-  
GO:0005615extracellular space-IDA16774925  
GO:0071944cell periphery-IDA16774925  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17204727Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function. (2007 Mar 15)Wilk JBAm J Respir Crit Care Med