Gene: BLM

641
BS|RECQ2|RECQL2|RECQL3
Bloom syndrome RecQ like helicase
protein-coding
15q26.1
Ensembl:ENSG00000197299 MIM:604610 Vega:OTTHUMG00000149834 UniprotKB:P54132
NG_007272.1
PubMed
0   ANCO-SNPs
ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.703e-1 (AD)  4.248e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LHFPL30.788
STK32A0.744
TMEM255A0.713
SEMA5A0.713
STK32B0.709
LUZP20.7
CCDC500.679
BCHE0.671
HAS20.665
CCND10.649

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIPK4-0.378
ADPRHL1-0.351
KSR2-0.338
CA7-0.335
PLXNA2-0.332
VWA7-0.327
ABCG8-0.324
BAAT-0.324
CYP4A22-0.321
CRHR2-0.321

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of BLM mRNA"19167446
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of BLM mRNA19191707
D000082AcetaminophenAcetaminophen results in increased expression of BLM mRNA22230336
D000082AcetaminophenAcetaminophen results in decreased expression of BLM mRNA17942131
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BLM mRNA22100608
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of BLM mRNA"22863853
D001151ArsenicArsenic results in decreased expression of BLM mRNA19945496
D001280AtrazineAtrazine results in decreased expression of BLM mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BLM mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BLM mRNA17942131
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BLM mRNA"19150397|2038263
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of BLM mRNA]24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of BLM mRNA21453500
D004958EstradiolEstradiol results in increased expression of BLM mRNA17268063|2475840
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of BLM mRNA]17268063
C006780bisphenol Abisphenol A results in decreased expression of BLM mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of BLM mRNA17268063|2212120
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of BLM mRNA]17268063
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of BLM mRNA17942131
C584509C646 compoundC646 compound results in decreased expression of BLM mRNA23698071
D000068579CelecoxibCelecoxib results in increased expression of BLM mRNA28201806
D002922CiguatoxinsCiguatoxins affects the expression of BLM mRNA18353800
D003078ColchicineColchicine results in decreased expression of BLM mRNA24211769
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of BLM mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of BLM mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of BLM mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of BLM mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of BLM mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of BLM mRNA21878529
D003471CuprizoneCuprizone results in increased expression of BLM mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of BLM mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of BLM mRNA17942131
D003703DemecolcineDemecolcine results in decreased expression of BLM mRNA23649840
D002945CisplatinCisplatin results in decreased expression of BLM mRNA24211769
D002945CisplatinCisplatin results in increased expression of BLM mRNA27594783
D002945CisplatinCisplatin results in increased expression of BLM mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of BLM mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of BLM mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of BLM mRNA21592394
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of BLM mRNA24211769
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of BLM exon17156454
D005047EtoposideEtoposide results in decreased expression of BLM mRNA24211769
D005472FluorouracilFluorouracil results in decreased expression of BLM mRNA19272435
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of BLM mRNA]17268063
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of BLM mRNA]17268063
D005839GentamicinsGentamicins results in decreased expression of BLM mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of BLM mRNA20044591
D006918HydroxyureaHydroxyurea results in decreased expression of BLM mRNA24211769
D006918HydroxyureaHydroxyurea results in increased expression of BLM mRNA18647660
D007052IbuprofenIbuprofen results in increased expression of BLM mRNA28201806
C056493imiquimodimiquimod results in decreased expression of BLM mRNA21878529
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BLM mRNA25613284
C544151jinfukangjinfukang results in increased expression of BLM mRNA27392435
D007854LeadLead results in decreased expression of BLM mRNA19921347
C533894LG 100815LG 100815 results in decreased expression of BLM mRNA16951191
D008154LucanthoneLucanthone results in decreased expression of BLM mRNA21148553
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of BLM mRNA21641980
D008628MercuryMercury binds to and results in decreased activity of BLM protein21440839
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of BLM mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of BLM mRNA24211769
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of BLM mRNA23649840
D016685MitomycinMitomycin results in decreased expression of BLM mRNA24211769
D009151Mustard GasMustard Gas results in decreased expression of BLM mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BLM mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BLM mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of BLM mRNA19812364
D009532NickelNickel results in increased expression of BLM mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of BLM mRNA20971185
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of BLM mRNA"16951191
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of BLM mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of BLM mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of BLM mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of BLM mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of BLM mRNA]26476374
D010433PentylenetetrazolePentylenetetrazole affects the expression of BLM mRNA21503142
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of BLM mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of BLM mRNA23091169
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of BLM mRNA21453500
C005556propionaldehydepropionaldehyde results in decreased expression of BLM mRNA26079696
D011794QuercetinQuercetin results in increased expression of BLM mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of BLM mRNA]26476374
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of BLM mRNA19167446
C547185riccardin Driccardin D results in decreased expression of and results in decreased activity of BLM protein24069304
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of BLM mRNA21641980
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of BLM mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of BLM mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BLM mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BLM mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of BLM protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of BLM mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of BLM mRNA27404394
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of BLM mRNA25729387
D019772TopotecanTopotecan results in decreased expression of BLM mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of BLM mRNA"17951470
D014212TretinoinTretinoin results in increased expression of BLM mRNA20488242
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of BLM mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BLM mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of BLM mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of BLM mRNA23179753|2718838
D014750VincristineVincristine results in decreased expression of BLM mRNA23649840
D000225AdenineAdenine results in decreased expression of BLM mRNA24211769

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000400four-way junction DNA binding-IBA21873635  
GO:0000400four-way junction DNA binding-IDA11735402  20639533  25901030  
GO:0000403Y-form DNA binding-IBA21873635  
GO:0000403Y-form DNA binding-IDA11735402  
GO:0000405bubble DNA binding-IBA21873635  
GO:0000405bubble DNA binding-IDA11433031  11735402  
GO:0002039p53 binding-IBA21873635  
GO:0002039p53 binding-IPI11781842  
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-IDA24816114  
GO:0003678DNA helicase activity-IDA19734539  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-IDA12818200  20639533  
GO:0004003ATP-dependent DNA helicase activity-IDA9388193  24816114  25901030  
GO:0004003ATP-dependent DNA helicase activity-IMP21325134  
GO:0004386helicase activity-IDA10871376  12181313  17878217  
GO:0005515protein binding-IPI10728666  10825162  11309417  11919194  12181313  12975363  
14688284  15229185  15775963  15965237  16030011  16864798  
17961633  20360068  20711169  20826342  21240188  21325134  
23509288  23708797  24126761  26496610  
GO:0005524ATP binding-IBA21873635  
GO:0005524ATP binding-IDA17878217  24816114  25901030  
GO:0008026ATP-dependent helicase activity-IDA12818200  
GO:0008094DNA-dependent ATPase activity-IDA24816114  25901030  
GO:0008270zinc ion binding-IBA21873635  
GO:0008270zinc ion binding-IDA24816114  25901030  
GO:0009378four-way junction helicase activity-IBA21873635  
GO:0009378four-way junction helicase activity-IDA11433031  11735402  12818200  25901030  
GO:0016887ATPase activity-IDA17878217  
GO:0036310annealing helicase activity-IBA21873635  
GO:0036310annealing helicase activity-IDA17878217  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0042803protein homodimerization activity-IDA28228481  
GO:0043140ATP-dependent 3'-5' DNA helicase activity-IBA21873635  
GO:0051880G-quadruplex DNA binding-IDA11433031  11735402  
GO:0061749forked DNA-dependent helicase activity-IBA21873635  
GO:0061749forked DNA-dependent helicase activity-IDA11735402  25901030  
GO:0061821telomeric D-loop binding-IBA21873635  
GO:0061821telomeric D-loop binding-IDA19734539  
GO:0061849telomeric G-quadruplex DNA binding-IC19734539  
GO:19057738-hydroxy-2'-deoxyguanosine DNA binding-IBA21873635  
GO:19057738-hydroxy-2'-deoxyguanosine DNA binding-IDA19734539  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IMP15604258  
GO:0000712resolution of meiotic recombination intermediates-IBA21873635  
GO:0000724double-strand break repair via homologous recombination-IBA21873635  
GO:0000724double-strand break repair via homologous recombination-NAS11309417  
GO:0000729DNA double-strand break processing-IDA21325134  
GO:0000731DNA synthesis involved in DNA repair-IBA21873635  
GO:0000732strand displacement-IBA21873635  
GO:0000733DNA strand renaturation-IEA-  
GO:0006260DNA replication-ISS-  
GO:0006260DNA replication-TAS-  
GO:0006281DNA repair-IBA21873635  
GO:0006281DNA repair-NAS7585968  
GO:0006303double-strand break repair via nonhomologous end joining-IBA21873635  
GO:0006310DNA recombination-IBA21873635  
GO:0006310DNA recombination-NAS7585968  10728666  
GO:0006974cellular response to DNA damage stimulus-IDA23509288  
GO:0006974cellular response to DNA damage stimulus-IMP12818200  
GO:0007095mitotic G2 DNA damage checkpoint-IBA21873635  
GO:0007095mitotic G2 DNA damage checkpoint-IDA11309417  
GO:0010165response to X-ray-IBA21873635  
GO:0010165response to X-ray-IDA11309417  
GO:0010705meiotic DNA double-strand break processing involved in reciprocal meiotic recombination-IBA21873635  
GO:0031297replication fork processing-IBA21873635  
GO:0031297replication fork processing-IDA17115688  
GO:0032508DNA duplex unwinding-IBA21873635  
GO:0032508DNA duplex unwinding-IDA11735402  24816114  25901030  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0044806G-quadruplex DNA unwinding-IBA21873635  
GO:0044806G-quadruplex DNA unwinding-IDA11735402  
GO:0044806G-quadruplex DNA unwinding-ISS-  
GO:0045003double-strand break repair via synthesis-dependent strand annealing-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IDA11781842  
GO:0045910negative regulation of DNA recombination-IMP9671747  
GO:0045950negative regulation of mitotic recombination-IBA21873635  
GO:0046632alpha-beta T cell differentiation-IBA21873635  
GO:0046641positive regulation of alpha-beta T cell proliferation-IBA21873635  
GO:0048478replication fork protection-NAS10779560  
GO:0051259protein complex oligomerization-IDA10359700  28228481  
GO:0051260protein homooligomerization-IBA21873635  
GO:0051260protein homooligomerization-IDA28228481  
GO:0051307meiotic chromosome separation-IBA21873635  
GO:0051782negative regulation of cell division-IBA21873635  
GO:0051782negative regulation of cell division-IMP11781842  
GO:0061820telomeric D-loop disassembly-IBA21873635  
GO:0061820telomeric D-loop disassembly-IDA19734539  
GO:0070244negative regulation of thymocyte apoptotic process-IBA21873635  
GO:0071139resolution of recombination intermediates-IBA21873635  
GO:0071479cellular response to ionizing radiation-IBA21873635  
GO:0071479cellular response to ionizing radiation-IDA23509288  
GO:0072711cellular response to hydroxyurea-IBA21873635  
GO:0072711cellular response to hydroxyurea-IDA23509288  
GO:0072757cellular response to camptothecin-IDA23509288  
GO:0090329regulation of DNA-dependent DNA replication-IBA21873635  
GO:0090329regulation of DNA-dependent DNA replication-IMP25901030  
GO:0090656t-circle formation-TAS27918544  
GO:1901291negative regulation of double-strand break repair via single-strand annealing-IBA21873635  
GO:1905168positive regulation of double-strand break repair via homologous recombination-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-IBA21873635  
GO:0000228nuclear chromosome-IDA23509288  
GO:0000781chromosome, telomeric regionCOLOCALIZES_WITHIBA21873635  
GO:0000781chromosome, telomeric regioncolocalizes_withIDA10779560  
GO:0000800lateral element-IBA21873635  
GO:0000800lateral element-IDA10728666  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9388480  11500040  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication fork-IBA21873635  
GO:0005657replication fork-ISS-  
GO:0005694chromosome-IBA21873635  
GO:0005730nucleolus-IBA21873635  
GO:0005730nucleolus-IDA10779560  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0016363nuclear matrix-IBA21873635  
GO:0016363nuclear matrix-IDA11309417  
GO:0016605PML bodyCOLOCALIZES_WITHIBA21873635  
GO:0016605PML body-IDA10728666  
GO:0016605PML bodycolocalizes_withIDA10779560  
GO:0045120pronucleus-IBA21873635  
KEGG ID KEGG Term
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2990846SUMOylationTAS
R-HSA-3108214SUMOylation of DNA damage response and repair proteinsTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21861943Folate malabsorption is associated with down-regulation of folate transporter expression and function at colon basolateral membrane in rats. (2012 Mar)Wani NABr J Nutr
22956120Decreased activity of folate transporters in lipid rafts resulted in reduced hepatic folate uptake in chronic alcoholism in rats. (2013 Mar)Wani NAGenes Nutr
18008023Decreased expression of transporters reduces folate uptake across renal absorptive surfaces in experimental alcoholism. (2007 Dec)Hamid AJ Membr Biol
24924712[Study on gene-gene, gene-environmental interactions of DNA repair genes related with age-related cataract]. (2014 Apr 22)Yang MZhonghua Yi Xue Za Zhi
10826102The effect of trifluoperazine on the genotoxicity of bleomycin in cultured human lymphocytes. (2000 May)Sadiq MFDrug Chem Toxicol
17953974Inherited susceptibility to bleomycin-induced micronuclei: correlating polymorphisms in GSTT1, GSTM1 and DNA repair genes with mutagen sensitivity. (2008 Feb 1)Angelini SMutat Res