Gene: NPFFR1

64106
GPR147|NPFF1|NPFF1R1|OT7T022
neuropeptide FF receptor 1
protein-coding
10q22.1
Ensembl:ENSG00000148734 MIM:607448 Vega:OTTHUMG00000018404 UniprotKB:Q9GZQ6
NC_000010.11
PubMed
0   ANCO-SNPs
OD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.869e-1 (AD)  5.036e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPAM0.759
ETNPPL0.73
MMP280.716
EYA10.707
PLIN50.705
CABLES10.699
EGFR0.699
GJB60.697
SPON10.692
ATP13A40.683

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FHL2-0.449
SH3BP1-0.42
SYNPO2-0.413
FAM162B-0.403
MUM1L1-0.402
HS3ST1-0.397
PLEKHA8P1-0.396
OSBPL10-0.394
HRK-0.394
GALNTL5-0.393

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NPFFR1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NPFFR1 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of NPFFR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NPFFR1 gene28505145
C039281furanfuran results in decreased expression of NPFFR1 mRNA25539665
D005839GentamicinsGentamicins results in decreased expression of NPFFR1 mRNA22061828
D010936Plant ExtractsPlant Extracts results in decreased expression of NPFFR1 mRNA23557933
C025643vinclozolinvinclozolin results in decreased expression of NPFFR1 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-NAS11024015  
GO:0008188neuropeptide receptor activity-NAS11024015  
GO:0042277peptide binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0008150biological_process-ND-  
GO:0032870cellular response to hormone stimulus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-389397Orexin and neuropeptides FF and QRFP bind to their respective receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27533886Anti-opioid Effects of RFRP-3 on Magnocellular Neuron Activity in Morphine-naive and Morphine-treated Female Rats. (2016 Oct)Kim JSEndocrinology