Gene: RTP4

64108
IFRG28|Z3CXXC4
receptor transporter protein 4
protein-coding
3q27.3
Ensembl:ENSG00000136514 MIM:609350 Vega:OTTHUMG00000156459 UniprotKB:Q96DX8
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.552e-1 (AD)  4.639e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX60L0.887
IFIH10.867
IFIT20.857
USP180.849
OAS10.846
OASL0.845
HERC50.841
DDX580.84
IFIT30.839
SAMD90.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCRT1-0.38
ADAMTSL2-0.367
ELFN2-0.365
ADRA1D-0.355
KIF21B-0.355
HRH3-0.35
INPP5J-0.344
GABRA5-0.344
FADS6-0.343
HCN2-0.341

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of RTP4 mRNA"28903501
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of RTP4 mRNA"20713471
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RTP4 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of RTP4 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of RTP4 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RTP4 mRNA27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RTP4 mRNA19770486|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RTP4 mRNA22228805|2373587
D004958EstradiolEstradiol results in increased expression of RTP4 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of RTP4 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RTP4 mRNA25993096
D002737ChloropreneChloroprene results in decreased expression of RTP4 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RTP4 mRNA28472532
C031180chrysenechrysene results in decreased expression of RTP4 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in decreased expression of RTP4 mRNA24386269
D003471CuprizoneCuprizone results in increased expression of RTP4 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of RTP4 mRNA22147139
D016572CyclosporineCyclosporine results in decreased expression of RTP4 mRNA19770486
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of RTP4 mRNA18242016|1964705
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RTP4 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of RTP4 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of RTP4 mRNA22061828
D017313FenretinideFenretinide results in increased expression of RTP4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RTP4 mRNA20044591
C051890irinotecanirinotecan affects the expression of RTP4 mRNA20097248
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RTP4 mRNA26752646
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RTP4 mRNA22235868
D008070LipopolysaccharidesLipopolysaccharides affects the expression of RTP4 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of RTP4 mRNA]28070326
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RTP4 mRNA25890327
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of RTP4 mRNA21641980
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of RTP4 mRNA20713471
C523799MRK 003RTP4 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RTP4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RTP4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RTP4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RTP4 mRNA"25554681
D009532NickelNickel results in increased expression of RTP4 mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RTP4 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of RTP4 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of RTP4 mRNA18242016|1964705
D010081OxazoloneOxazolone results in increased expression of RTP4 mRNA21893156
D010416PentachlorophenolPentachlorophenol results in increased expression of RTP4 mRNA23892564
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RTP4 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of RTP4 mRNA23811191
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of RTP4 mRNA]28070326
D010936Plant ExtractsPlant Extracts results in increased expression of RTP4 mRNA21297082
D011441PropylthiouracilPropylthiouracil results in increased expression of RTP4 mRNA24780913
D012834SilverSilver affects the expression of RTP4 mRNA27131904
D012906SmokeSmoke results in decreased expression of RTP4 mRNA21095227
D053260SootSoot results in increased expression of RTP4 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of RTP4 mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of RTP4 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of RTP4 mRNA20937368
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of RTP4 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RTP4 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of RTP4 mRNA23411599
D013853ThioacetamideThioacetamide results in increased methylation of RTP4 promoter27914986
C009495titanium dioxidetitanium dioxide affects the expression of RTP4 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of RTP4 mRNA23557971
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of RTP4 mRNA"18242016|1964705
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RTP4 mRNA25729387
D019772TopotecanTopotecan results in increased expression of RTP4 mRNA25729387
D014212TretinoinTretinoin results in increased expression of RTP4 mRNA23830798
D014241TrichloroethyleneTrichloroethylene results in increased methylation of RTP4 gene27618143
D014635Valproic AcidValproic Acid results in decreased expression of RTP4 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the expression of RTP4 mRNA23940539
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RTP4 gene25560391
C025643vinclozolinvinclozolin affects the expression of RTP4 mRNA19015723|2303416

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16720576  
GO:0031849olfactory receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste-IBA21873635  
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste-IDA16720576  
GO:0006612protein targeting to membrane-IBA21873635  
GO:0006612protein targeting to membrane-IDA16720576  
GO:0051205protein insertion into membrane-IBA21873635  
GO:0051607defense response to virus-IDA21478870  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA16720576  
GO:0009986cell surface-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-381753Olfactory Signaling PathwayTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27980621Analysis of gene expression to predict dynamics of future hypertension incidence in type 2 diabetic patients. (2016)Radkowski PBMC Proc