Gene: SLC39A8

64116
BIGM103|CDG2N|LZT-Hs6|PP3105|ZIP8
solute carrier family 39 member 8
protein-coding
4q24
Ensembl:ENSG00000138821 MIM:608732 Vega:OTTHUMG00000131120 UniprotKB:Q9C0K1
NG_047177.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.598e-1 (AD)  9.775e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFBR20.815
ABCB10.807
CYYR10.79
EMCN0.789
MYCT10.789
PAQR50.788
FOXC10.784
ITGA60.779
MECOM0.778
ITGA10.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRD5-0.442
ISLR2-0.426
DLK2-0.379
KCNG1-0.371
SLC7A4-0.367
TMEM121-0.36
KCNG2-0.359
GGN-0.358
NTSR1-0.357
HAS1-0.35

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SLC39A8 mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SLC39A8 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC39A8 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SLC39A8 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC39A8 mRNA"23146750
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of SLC39A8 protein22345571
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC39A8 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC39A8 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC39A8 mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of SLC39A8 mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC39A8 mRNA24449571
D001151ArsenicArsenic results in decreased expression of SLC39A8 mRNA19654921
C547126AZM551248AZM551248 results in decreased expression of SLC39A8 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of SLC39A8 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC39A8 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SLC39A8 mRNA20660070
D004958EstradiolEstradiol results in increased expression of SLC39A8 mRNA16474171|1916744
D004958EstradiolEstradiol results in increased expression of SLC39A8 mRNA15289156
D001639BicarbonatesBicarbonates promotes the reaction [SLC39A8 protein results in increased uptake of Cadmium]16638970
D001639BicarbonatesSLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates]16638970
C006780bisphenol Abisphenol A results in increased expression of SLC39A8 mRNA16474171
C006780bisphenol Abisphenol A results in increased expression of SLC39A8 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SLC39A8 mRNA16997883
D002104CadmiumCadmium results in decreased expression of SLC39A8 mRNA18556457
D002104Cadmium[GCLC results in decreased uptake of Cadmium] which results in decreased expression of SLC39A818556457
D002104CadmiumSLC39A8 mutant form inhibits the reaction [TNF protein results in increased uptake of Cadmium]22345571
D002104CadmiumSLC39A8 protein polymorphism affects the uptake of Cadmium26102734
D002104Cadmium[SLC39A8 protein polymorphism affects the uptake of Cadmium] which affects the phosphorylation of MAPK1 protein26102734
D002104Cadmium[SLC39A8 protein polymorphism affects the uptake of Cadmium] which affects the phosphorylation of MAPK3 protein26102734
D002104CadmiumBicarbonates promotes the reaction [SLC39A8 protein results in increased uptake of Cadmium]16638970
D002104CadmiumManganese inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]16638970
D002104CadmiumMercury inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]16638970
D002104CadmiumPotassium Cyanide inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]16638970
D002104CadmiumSLC39A8 protein affects the susceptibility to Cadmium16638970
D002104CadmiumSLC39A8 protein results in increased uptake of Cadmium16638970
D002104CadmiumSLC39A8 results in increased susceptibility to Cadmium19194888
D002104CadmiumSLC39A8 protein results in increased import of Cadmium22898811
D002104CadmiumSLC39A8 protein results in increased uptake of Cadmium22345571
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC39A8 mRNA23811327|2764747
D019256Cadmium ChlorideSLC39A8 affects the uptake of Cadmium Chloride18556457
D019256Cadmium Chloride[SLC39A8 mutant form results in decreased expression of SP1] which affects the susceptibility to Cadmium Chloride18556457
D019256Cadmium Chloride[SLC39A8 mutant form results in decreased expression of SP1] which results in decreased uptake of Cadmium Chloride18556457
D019256Cadmium ChlorideSLC39A8 protein results in increased susceptibility to Cadmium Chloride19699220
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC39A8 mRNA25653005
D019256Cadmium ChlorideSLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of Cadmium Chloride]21509381
D019256Cadmium ChlorideSLC39A8 protein results in increased uptake of Cadmium Chloride21509381
D019256Cadmium Chloridezinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of SLC39A8 mRNA]25653005
D002737ChloropreneChloroprene results in decreased expression of SLC39A8 mRNA23125180
D002994ClofibrateClofibrate affects the expression of SLC39A8 mRNA19483382
D003035CobaltCobalt inhibits the reaction [SLC39A8 protein results in increased import of Iron]22898811
D003035CobaltSLC39A8 protein results in increased import of Cobalt22898811
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC39A8 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SLC39A8 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SLC39A8 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of SLC39A8 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of SLC39A8 mRNA22147139
C017180decamethrindecamethrin results in decreased expression of SLC39A8 mRNA19017407
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SLC39A8 mRNA16997883
D004041Dietary FatsDietary Fats results in increased expression of SLC39A8 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of SLC39A8 mRNA]19030233
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SLC39A8 mRNA15289156
D002117CalcitriolCalcitriol results in decreased expression of SLC39A8 mRNA20089671
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SLC39A8 mRNA25380136
D004237DiuronDiuron results in decreased expression of SLC39A8 mRNA21551480|2515243
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of SLC39A8 mRNA19118595
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC39A8 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC39A8 mRNA17942748
D005001EthionineEthionine affects the expression of SLC39A8 mRNA19483382
D005485FlutamideFlutamide results in decreased expression of SLC39A8 mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of SLC39A8 mRNA19167457
D019833GenisteinGenistein results in increased expression of SLC39A8 mRNA16474171
D019833GenisteinGenistein results in increased expression of SLC39A8 mRNA15289156
D005897GlafenineGlafenine results in decreased expression of SLC39A8 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of SLC39A8 mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SLC39A8 mRNA25613284
D007501IronSLC39A8 protein results in increased import of Iron22898811
D007501IronProtons affects the reaction [SLC39A8 protein results in increased import of Iron]22898811
D007501IronSLC39A8 protein results in increased import of Iron22898811
D007501IronCobalt inhibits the reaction [SLC39A8 protein results in increased import of Iron]22898811
D007501IronIron inhibits the reaction [SLC39A8 protein results in increased import of Zinc]22898811
D007501IronIron results in increased expression of and affects the localization of SLC39A8 protein22898811
D007501IronManganese inhibits the reaction [SLC39A8 protein results in increased import of Iron]22898811
D007501IronSLC39A8 protein results in increased import of Iron22898811
D007501IronZinc inhibits the reaction [SLC39A8 protein results in increased import of Iron]22898811
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SLC39A8 mRNA16997883
C544151jinfukangjinfukang results in decreased expression of SLC39A8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC39A8 mRNA26752646
C008261lead acetatelead acetate results in decreased expression of SLC39A8 mRNA22613225
C008261lead acetatelead acetate results in decreased expression of SLC39A8 mRNA22641619
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SLC39A8 mRNA25613284
D008345ManganeseSLC39A8 gene SNP affects the transport of Manganese26025379
D008345ManganeseSLC39A8 SNP affects the transport of Manganese28917719
D008345ManganeseManganese inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]16638970
D008345ManganeseSLC39A8 protein results in increased uptake of Manganese16638970
D008345ManganeseSLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates]16638970
D008345ManganeseManganese inhibits the reaction [SLC39A8 protein results in increased import of Iron]22898811
D008345ManganeseSLC39A8 protein results in increased import of Manganese22898811
C025340manganese chlorideSLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of manganese chloride]21509381
C025340manganese chlorideSLC39A8 protein results in increased uptake of manganese chloride21509381
C042720mercuric bromidemercuric bromide results in increased expression of SLC39A8 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
D008628MercuryMercury inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]16638970
D008727MethotrexateMethotrexate affects the expression of SLC39A8 mRNA18502557
C002950methylformamidemethylformamide analog results in increased expression of SLC39A8 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of SLC39A8 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLC39A8 mRNA26272509
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC39A8 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC39A8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC39A8 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC39A8 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLC39A8 mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SLC39A8 mRNA19812364
C051752nefazodonenefazodone results in decreased expression of SLC39A8 mRNA24136188
D009532NickelNickel results in increased expression of SLC39A8 mRNA24768652|2558310
C012655nimesulidenimesulide results in decreased expression of SLC39A8 mRNA24136188
D009853OmeprazoleOmeprazole affects the expression of SLC39A8 mRNA19483382
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SLC39A8 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of SLC39A8 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of SLC39A8 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLC39A8 mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in decreased expression of SLC39A8 mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC39A8 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of SLC39A8 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of SLC39A8 mRNA22484513
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of SLC39A8 mRNA16474171
D011190Potassium CyanidePotassium Cyanide inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]16638970
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SLC39A8 mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of SLC39A8 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of SLC39A8 mRNA19483382|2478091
D011522ProtonsProtons affects the reaction [SLC39A8 protein results in increased import of Iron]22898811
C012526quercitrinquercitrin results in decreased expression of SLC39A8 mRNA25193878
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SLC39A8 mRNA19167446
D015474IsotretinoinIsotretinoin results in decreased expression of SLC39A8 mRNA20436886
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of SLC39A8 mRNA]19030233
D012906SmokeSmoke results in increased expression of SLC39A8 mRNA22345571
D012906SmokeSmoke results in increased expression of SLC39A8 protein22345571
C017947sodium arsenitesodium arsenite results in decreased expression of SLC39A8 protein21925251
C017947sodium arsenitesodium arsenite results in increased expression of SLC39A8 mRNA22714537
D017693Sodium BicarbonateSLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of Cadmium Chloride]21509381
D017693Sodium BicarbonateSLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of manganese chloride]21509381
D012999SomanSoman results in decreased expression of SLC39A8 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC39A8 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC39A8 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC39A8 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC39A8 mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SLC39A8 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of SLC39A8 mRNA19483382
D014050TolueneToluene results in increased expression of SLC39A8 mRNA22967744
D019772TopotecanSLC39A8 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in decreased expression of SLC39A8 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLC39A8 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC39A8 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLC39A8 mRNA23179753|2438349
D014640VancomycinVancomycin results in increased expression of SLC39A8 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC39A8 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC39A8 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC39A8 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SLC39A8 mRNA26272509
D015032ZincSLC39A8 protein results in increased transport of Zinc18326752
D015032Zinc[TNF protein results in increased expression of SLC39A8 protein] which results in increased import of Zinc18390834
D015032ZincZinc results in decreased expression of SLC39A8 mRNA17085522
D015032ZincIron inhibits the reaction [SLC39A8 protein results in increased import of Zinc]22898811
D015032ZincSLC39A8 protein results in increased import of Zinc22898811
D015032ZincZinc deficiency results in decreased expression of SLC39A8 mRNA20859692
D015032ZincZinc inhibits the reaction [SLC39A8 protein results in increased import of Iron]22898811
D015032ZincZinc results in increased expression of SLC39A8 protein22898811
D015032ZincSLC39A8 protein results in increased uptake of Zinc17126599
C016837zinc chloridezinc chloride inhibits the reaction [Cadmium Chloride results in increased expression of SLC39A8 mRNA]25653005
C088658zoledronic acidzoledronic acid results in increased expression of SLC39A8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005385zinc ion transmembrane transporter activity-IBA21873635  
GO:0005385zinc ion transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006829zinc ion transport-IMP12504855  
GO:0006882cellular zinc ion homeostasis-IBA21873635  
GO:0070574cadmium ion transmembrane transport-IEA-  
GO:0071578zinc ion import across plasma membrane-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0031090organelle membrane-IDA12504855  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425410Metal ion SLC transportersTAS
R-HSA-435354Zinc transportersTAS
R-HSA-442380Zinc influx into cells by the SLC39 gene familyTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23372645Graphical modeling of gene expression in monocytes suggests molecular mechanisms explaining increased atherosclerosis in smokers. (2013)Verdugo RAPLoS One
22345571Cadmium-mediated toxicity of lung epithelia is enhanced through NF-kappaB-mediated transcriptional activation of the human zinc transporter ZIP8. (2012 May 1)Napolitano JRAm J Physiol Lung Cell Mol Physiol