Gene: TINAGL1

64129
ARG1|LCN7|LIECG3|TINAGRP
tubulointerstitial nephritis antigen like 1
protein-coding
1p35.2
Ensembl:ENSG00000142910 MIM:616064 Vega:OTTHUMG00000003884 UniprotKB:Q9GZM7
NG_028164.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.046e-2 (AD)  1.785e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03314569chr1:32041732TINAGL18.900e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DOCK60.835
MYO1C0.834
PEAR10.83
CDH50.802
PKN30.797
ICAM20.792
MMRN20.791
ESAM0.789
TBX20.785
TCIRG10.784

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM18-0.506
CRH-0.457
MARCH4-0.442
PPEF1-0.434
FSTL5-0.423
PRLHR-0.423
VWC2-0.42
ABCC12-0.418
NMU-0.415
PTPRR-0.409

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TINAGL1 mRNA"26377693
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TINAGL1 mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TINAGL1 mRNA"19114083
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of TINAGL1 mRNA25088246
D000082AcetaminophenAcetaminophen results in increased expression of TINAGL1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of TINAGL1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TINAGL1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TINAGL1 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of TINAGL1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TINAGL1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TINAGL1 mRNA21569818|2261060
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TINAGL1 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of TINAGL1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased methylation of TINAGL1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of TINAGL1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TINAGL1 mRNA15003993
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TINAGL1 mRNA21457566
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TINAGL1 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride affects the expression of TINAGL1 mRNA22110744
D002737ChloropreneChloroprene results in increased expression of TINAGL1 mRNA23125180
D003345CorticosteroneCorticosterone results in increased expression of TINAGL1 mRNA15755911
D003471CuprizoneCuprizone results in increased expression of TINAGL1 mRNA26577399
C009160cyclonitecyclonite results in increased expression of TINAGL1 mRNA25559034
D003907DexamethasoneDexamethasone results in increased expression of TINAGL1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of TINAGL1 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TINAGL1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TINAGL1 mRNA21266533
D002117CalcitriolCalcitriol results in increased expression of TINAGL1 mRNA16002434
C540355fenamidonefenamidone results in increased expression of TINAGL1 mRNA27029645
D017313FenretinideFenretinide results in increased expression of TINAGL1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TINAGL1 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of TINAGL1 mRNA20003209
C008261lead acetatelead acetate results in increased expression of TINAGL1 mRNA22613225
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TINAGL1 mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of TINAGL1 mRNA17412507
C568376MT19c compoundMT19c compound results in decreased expression of TINAGL1 mRNA21781307
C500085muraglitazarmuraglitazar results in increased expression of TINAGL1 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of TINAGL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TINAGL1 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of TINAGL1 mRNA18978301
C017096n-butoxyethanoln-butoxyethanol results in increased expression of TINAGL1 mRNA19812364
D009538NicotineNicotine results in increased expression of TINAGL1 mRNA23825647
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TINAGL1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of TINAGL1 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TINAGL1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of TINAGL1 mRNA17426115
D011374ProgesteroneProgesterone results in increased expression of TINAGL1 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of TINAGL1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TINAGL1 mRNA27029645
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of TINAGL1 mRNA"16251409
D053260SootSoot results in increased expression of TINAGL1 mRNA26551751
C501413tesaglitazartesaglitazar results in increased expression of TINAGL1 mRNA21515302
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of TINAGL1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TINAGL1 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of TINAGL1 mRNA]15667827
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TINAGL1 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of TINAGL1 mRNA26217789
D014050TolueneToluene results in decreased expression of TINAGL1 mRNA28245982
D014212TretinoinTretinoin results in increased expression of TINAGL1 mRNA17138961
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TINAGL1 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of TINAGL1 mRNA21515302
D014635Valproic AcidValproic Acid results in increased expression of TINAGL1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of TINAGL1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of TINAGL1 mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of TINAGL1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-IBA21873635  
GO:0005044scavenger receptor activity-IEA-  
GO:0005201extracellular matrix structural constituent-NAS11170462  
GO:0005515protein binding-IPI25416956  
GO:0030247polysaccharide binding-IEA-  
GO:0043236laminin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0006955immune response-IEA-  
GO:0007155cell adhesion-IBA21873635  
GO:0016197endosomal transport-TAS10799322  
GO:0051603proteolysis involved in cellular protein catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS11170462  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-ISS22261194  
GO:0005764lysosome-IBA21873635  
GO:0062023collagen-containing extracellular matrix-HDA23979707  27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal