Gene: XYLT2

64132
PXYLT2|SOS|XT-II|XT2|xylT-II
xylosyltransferase 2
protein-coding
17q21.33
Ensembl:ENSG00000015532 MIM:608125 Vega:OTTHUMG00000162057 UniprotKB:Q9H1B5
NG_012175.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.496e-2 (AD)  8.006e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24804060chr17:48425014XYLT2Gene body4.720e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLUH0.909
SCAP0.904
NLGN20.904
ARHGEF170.9
ATF6B0.898
TMUB20.896
GBF10.892
SH2B10.891
AP1B10.891
LZTR10.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.625
OR4F29-0.547
CTNNA3-0.377
OR6C74-0.357
CNTF-0.356
SGMS2-0.344
KLRC2-0.329
ANXA13-0.327
C9orf153-0.321
TFPI2-0.317

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of XYLT2 mRNA"19162173
D000643Ammonium ChlorideAmmonium Chloride affects the expression of XYLT2 mRNA16483693
D001151ArsenicArsenic affects the methylation of XYLT2 gene25304211
C044887beta-methylcholinebeta-methylcholine affects the expression of XYLT2 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of XYLT2 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of XYLT2 mRNA26191083
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of XYLT2 mRNA17602206
D003300Copper[Disulfiram binds to Copper] which results in increased expression of XYLT2 mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of XYLT2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of XYLT2 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of XYLT2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of XYLT2 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of XYLT2 mRNA17602206
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of XYLT2 mRNA24690739
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XYLT2 mRNA22079256
D005485FlutamideFlutamide results in decreased expression of XYLT2 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of XYLT2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of XYLT2 mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of XYLT2 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of XYLT2 mRNA20044591
D007213IndomethacinIndomethacin results in increased expression of XYLT2 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of XYLT2 mRNA27392435
D007649KetamineKetamine results in increased expression of XYLT2 mRNA20080153
D007854LeadLead affects the expression of XYLT2 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of XYLT2 mRNA21641980
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of XYLT2 mRNA17616710
D010938Plant OilsPlant Oils results in decreased expression of XYLT2 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XYLT2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of XYLT2 mRNA22079256
D012402RotenoneRotenone results in decreased expression of XYLT2 mRNA19013527
D012999SomanSoman results in decreased expression of XYLT2 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of XYLT2 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XYLT2 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of XYLT2 mRNA28065790

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008375acetylglucosaminyltransferase activity-IEA-  
GO:0030158protein xylosyltransferase activity-NAS11099377  
GO:0030158protein xylosyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006024glycosaminoglycan biosynthetic process-NAS11099377  
GO:0015012heparan sulfate proteoglycan biosynthetic process-IEA-  
GO:0015012heparan sulfate proteoglycan biosynthetic process-IMP26027496  
GO:0030203glycosaminoglycan metabolic process-TAS-  
GO:0030206chondroitin sulfate biosynthetic process-IEA-  
GO:0030210heparin biosynthetic process-IEA-  
GO:0050650chondroitin sulfate proteoglycan biosynthetic process-IMP26027496  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005575cellular_component-ND-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-1971475A tetrasaccharide linker sequence is required for GAG synthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23542338A genomewide association study of smoking relapse in four European population-based samples. (2013 Aug)Tozzi FPsychiatr Genet