Gene: ABCG4

64137
WHITE2
ATP binding cassette subfamily G member 4
protein-coding
11q23.3
Ensembl:ENSG00000172350 MIM:607784 Vega:OTTHUMG00000166169 UniprotKB:Q9H172
NG_047178.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.121e-1 (AD)  8.918e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13063614chr11:119020779ABCG4Gene body3.488e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLSTN30.966
LRRC40.959
SLC12A50.958
KCNB10.957
L1CAM0.954
LRTM20.954
ATP2B30.953
MAP3K90.953
KCNC10.953
SYT30.951

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.648
REST-0.646
RAI14-0.641
WWTR1-0.623
HEY2-0.616
CNN2-0.591
SGMS2-0.586
RAB13-0.58
ACTL6A-0.579
MYL3-0.575

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA]22129741
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ABCG4 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ABCG4 mRNA22100608
D000447AldehydesAldehydes results in increased expression of ABCG4 mRNA25014914
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ABCG4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABCG4 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ABCG4 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ABCG4 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of ABCG4 mRNA26496021
C018475butyraldehydebutyraldehyde results in increased expression of ABCG4 mRNA26079696
D003300CopperCopper results in decreased expression of ABCG4 mRNA18522721
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ABCG4 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ABCG4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ABCG4 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of ABCG4 mRNA25016146
D004052DiethylnitrosamineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA]22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ABCG4 mRNA22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA22129741
C056516exemestaneexemestane results in increased expression of ABCG4 mRNA17254854
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of ABCG4 mRNA22634610
D017313FenretinideFenretinide results in decreased expression of ABCG4 mRNA28973697
C016517indole-3-carbinolAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA]22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ABCG4 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCG4 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ABCG4 mRNA27392435
D007854LeadLead affects the expression of ABCG4 mRNA28903495
D008727MethotrexateMethotrexate affects the expression of ABCG4 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ABCG4 mRNA"20188158
D009840OligomycinsOligomycins results in increased expression of ABCG4 mRNA23227865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ABCG4 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ABCG4 mRNA25729387
C046012pentanalpentanal results in increased expression of ABCG4 mRNA26079696
D026023PermethrinPermethrin results in increased expression of ABCG4 mRNA25073980
D011192Potassium DichromatePotassium Dichromate results in increased expression of ABCG4 mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of ABCG4 mRNA26079696
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of ABCG4 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCG4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCG4 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCG4 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ABCG4 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ABCG4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ABCG4 mRNA25729387
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ABCG4 gene25560391
D014750Vincristine[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCG4 mRNA19944135

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16870176  
GO:0005524ATP binding-IEA-  
GO:0017127cholesterol transporter activity-IBA21873635  
GO:0017127cholesterol transporter activity-TAS-  
GO:0034041sterol-transporting ATPase activity-IBA21873635  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0042803protein homodimerization activity-IDA16870176  
GO:0046982protein heterodimerization activity-IPI16870176  
GO ID GO Term Qualifier Evidence PubMed
GO:0030301cholesterol transport-IBA21873635  
GO:0033344cholesterol efflux-IBA21873635  
GO:0033344cholesterol efflux-TAS16682745  
GO:0055085transmembrane transport-IBA21873635  
GO:0055085transmembrane transport-TAS-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
hsa02010ABC transporters
Reactome ID Reactome Term Evidence
R-HSA-1369062ABC transporters in lipid homeostasisTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics
19405812Age-associated decrease of high-density lipoprotein-mediated reverse cholesterol transport activity. (2009 Apr)Berrougui HRejuvenation Res