Gene: ACOT6

641372
C14orf42|c14_5530
acyl-CoA thioesterase 6
protein-coding
14q24.3
Ensembl:ENSG00000205669 MIM:614267 Vega:OTTHUMG00000171609 UniprotKB:Q3I5F7
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
9.344e-1 (AD)  7.206e-1 (ND)   (Frontal_Cortex)
8.782e-1 (AD)  4.130e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SDS0.664
DECR10.663
GRAMD1C0.643
MMP280.642
EGLN30.638
ETNPPL0.637
HOGA10.636
RGS200.636
TLCD10.634
PLIN50.634

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC36A1-0.454
KIAA1549-0.454
OSBPL10-0.446
EPHA3-0.44
MCHR1-0.437
ARHGAP20-0.437
IL12RB2-0.435
LGI2-0.435
TC2N-0.428
TMEM200C-0.425

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ACOT6 mRNA"20453058
D001151ArsenicArsenic affects the methylation of ACOT6 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ACOT6 promoter]19654925
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in increased expression of ACOT6 mRNA]24758408
D004958EstradiolEstradiol results in increased expression of ACOT6 mRNA24758408
C006780bisphenol Abisphenol A results in decreased expression of ACOT6 mRNA25181051
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ACOT6 mRNA28962523
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ACOT6 mRNA]"23626681
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of ACOT6 mRNA"27840820
D000431EthanolEthanol results in increased expression of ACOT6 mRNA19167417
C000625835HFPO2 compoundHFPO2 compound results in increased expression of ACOT6 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of ACOT6 mRNA27553808
D017313FenretinideFenretinide results in decreased expression of ACOT6 mRNA28973697
C052901lemongrass oillemongrass oil affects the expression of ACOT6 mRNA25976427
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ACOT6 mRNA"24972896
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of ACOT6 mRNA]"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ACOT6 mRNA23626681
C006253pirinixic acidpirinixic acid results in increased expression of ACOT6 mRNA20813756|2381119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ACOT6 mRNA22698814
D014241TrichloroethyleneTrichloroethylene results in increased expression of ACOT6 mRNA25549359

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0047617acyl-CoA hydrolase activity-IBA21873635  
GO:0047617acyl-CoA hydrolase activity-TAS-  
GO:0052689carboxylic ester hydrolase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006631fatty acid metabolic process-IBA21873635  
GO:0006637acyl-CoA metabolic process-IBA21873635  
GO:0006637acyl-CoA metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005782peroxisomal matrix-TAS-  
GO:0005829cytosol-IDA16940157  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-390247Beta-oxidation of very long chain fatty acidsTAS
R-HSA-390918Peroxisomal lipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24479813ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma. (2014 Jan 31)Eckel-Passow JEBMC Urol