Gene: PDF

64146
-
peptide deformylase, mitochondrial
protein-coding
16q22.1
Ensembl:ENSG00000258429 Vega:OTTHUMG00000171336 UniprotKB:Q9HBH1
NG_033043.1
PubMed
0   ANCO-SNPs
OD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFBR3L0.839
SLC39A30.832
ENDOG0.831
MBLAC10.823
MCAT0.814
FBXW90.813
NCBP2-AS20.808
SLC35E40.797
GLTPD20.795
C2CD4D0.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.527
REST-0.513
P2RY14-0.513
DISC1-0.496
PARD3B-0.493
NEK7-0.491
CARD8-0.474
PRKD3-0.466
PELI2-0.464
DOCK1-0.464

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000638AmiodaroneAmiodarone results in increased expression of PDF mRNA19774075
D001151ArsenicArsenic affects the methylation of PDF gene25304211
C015001arsenitearsenite results in increased methylation of PDF promoter23974009
C006780bisphenol Abisphenol A results in increased expression of PDF mRNA28159858
C006780bisphenol Abisphenol A results in decreased expression of PDF mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of PDF mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PDF mRNA28472532
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PDF mRNA17361019
D004726EndosulfanEndosulfan results in increased expression of PDF mRNA21036383
C082360fipronilfipronil results in increased expression of PDF mRNA23962444
D005472FluorouracilFluorouracil results in increased expression of PDF mRNA16510598
D005472FluorouracilFluorouracil results in increased expression of PDF protein16510598
D005472FluorouracilPDF protein results in decreased susceptibility to Fluorouracil16510598
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PDF mRNA26011545
C030110oxaliplatinoxaliplatin results in increased expression of PDF mRNA16510598
C030110oxaliplatinoxaliplatin results in increased expression of PDF protein16510598
C030110oxaliplatinPDF protein results in decreased susceptibility to oxaliplatin16510598
D010100OxygenOxygen deficiency results in decreased expression of PDF mRNA26516004
D010433PentylenetetrazolePentylenetetrazole affects the expression of PDF mRNA21503142
D012834SilverSilver results in decreased expression of PDF mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of PDF mRNA23922661
D014520UrethaneUrethane results in decreased expression of PDF mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042586peptide deformylase activity-IBA21873635  
GO:0042586peptide deformylase activity-IDA15489958  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006412translation-IEA-  
GO:0008284positive regulation of cell proliferation-IMP15489958  
GO:0018206peptidyl-methionine modification-IBA21873635  
GO:0018206peptidyl-methionine modification-IDA15489958  
GO:0031365N-terminal protein amino acid modification-IBA21873635  
GO:0031365N-terminal protein amino acid modification-IDA15489958  
GO:0043686co-translational protein modification-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA15489958  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19348387Ethanol and cardiovascular diseases: epidemiological, biochemical and clinical aspects. (2008)Ginter EBratisl Lek Listy
20017460Screening for depression in survivors of metastatic ovarian cancer in a programme of palliative cancer care. (2009)Slovacek LBratisl Lek Listy
24329508sTREM-1 in bronchoalveolar lavage fluid in patients with pulmonary sarcoidosis, effect of smoking and inflammation. (2013)Suchankova MBratisl Lek Listy
17694807Some indicators of quality of life in senior age in two regions international comparative study--the Czech Republic and the Slovak Republic. (2007)Zavazalova HBratisl Lek Listy
24329512A high oxidative stress index predicts endothelial dysfunction in young male smokers. (2013)Karahan OBratisl Lek Listy
19711824The relationship between cell surface markers, cytokines, ageing, and cigarette smoking. (2009)Horvathova MBratisl Lek Listy
19507651Some cardiovascular risk factors in Gypsy children and adolescents from Central Slovakia. (2009)Hujova ZBratisl Lek Listy
17685008Ischemic disease of lower extremities--risk factors and ultrasound diagnostic. (2007)Bodikova SBratisl Lek Listy