Gene: ERAP2

64167
L-RAP|LRAP
endoplasmic reticulum aminopeptidase 2
protein-coding
5q15
Ensembl:ENSG00000164308 MIM:609497 Vega:OTTHUMG00000128718 UniprotKB:Q6P179
NG_051092.1
PubMed
0   ANCO-SNPs
ND
1   
9.482e-1 (AD)  9.744e-1 (ND)   (Frontal_Cortex)
2.183e-1 (AD)  5.025e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IFIH10.594
PARP90.588
PARP120.583
BTN3A10.58
SAMD9L0.58
IFIT20.578
APOL30.577
DDX580.576
RTP40.571
TLR30.571

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C14orf180-0.311
YBX2-0.274
CHRNA2-0.269
ABCC12-0.268
SEZ6-0.266
VIP-0.263
VGF-0.26
MARCH4-0.259
KCNB2-0.257
ADRA1D-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of ERAP2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ERAP2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ERAP2 gene27153756
C547126AZM551248AZM551248 results in decreased expression of ERAP2 mRNA22323515
C100187chloropicrinchloropicrin results in increased expression of ERAP2 mRNA26352163
D019327Copper SulfateCopper Sulfate results in decreased expression of ERAP2 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of ERAP2 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of ERAP2 mRNA21632981|2556210
D003703DemecolcineDemecolcine results in increased expression of ERAP2 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ERAP2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ERAP2 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of ERAP2 mRNA28302478
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ERAP2 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of ERAP2 mRNA23649840
C492448ICG 001ICG 001 results in increased expression of ERAP2 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ERAP2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERAP2 mRNA24796395|2675264
D007840LatexLatex analog results in increased expression of ERAP2 mRNA24768652
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ERAP2 mRNA22235868
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ERAP2 mRNA23649840
D009532NickelNickel results in increased expression of ERAP2 mRNA25583101
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ERAP2 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of ERAP2 protein23718831
D011374ProgesteroneProgesterone results in decreased expression of ERAP2 mRNA19690047
C017947sodium arsenitesodium arsenite results in decreased expression of ERAP2 mRNA22714537
C004648testosterone enanthatetestosterone enanthate affects the expression of ERAP2 mRNA17440010
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ERAP2 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ERAP2 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ERAP2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ERAP2 mRNA29154799
D014750VincristineVincristine results in increased expression of ERAP2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-EXP12436109  12436110  17088086  
GO:0004177aminopeptidase activity-IDA12799365  
GO:0008237metallopeptidase activity-IDA12799365  
GO:0008270zinc ion binding-IBA21873635  
GO:0008270zinc ion binding-TAS12799365  
GO:0042277peptide binding-IBA21873635  
GO:0070006metalloaminopeptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0002474antigen processing and presentation of peptide antigen via MHC class I-TAS-  
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0008217regulation of blood pressure-TAS12799365  
GO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class I-TAS15691326  
GO:0043171peptide catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS15691326  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHCTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25609128[A study on the relationship between endoplasmic reticulum aminopeptidase2 genetic polymorphisms and non-small cell lung cancer in Yunnan Han population]. (2014 Dec)Zhou JZhonghua Jie He He Hu Xi Za Zhi