Gene: TFB2M

64216
Hkp1|mtTFB2
transcription factor B2, mitochondrial
protein-coding
1q44
Ensembl:ENSG00000162851 MIM:607055 Vega:OTTHUMG00000040091 UniprotKB:Q9H5Q4
NC_000001.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.351e-1 (AD)  2.804e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3120701chr1:246542837 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATG50.924
RNGTT0.905
RBM180.905
FBXO280.905
TM2D20.904
NRBF20.904
RANBP60.903
KIAA08950.902
RTCA0.902
NUP500.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.463
OR4F29-0.416
CSAG1-0.368
ANPEP-0.362
MYOM1-0.35
P2RY14-0.35
MTRNR2L10-0.349
CD248-0.347
MTRNR2L9-0.344
MAGEA12-0.337

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TFB2M mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of TFB2M mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TFB2M mRNA"21346803
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of TFB2M mRNA"19561079
D000082AcetaminophenAcetaminophen results in decreased expression of TFB2M mRNA22230336|2570463
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TFB2M mRNA24449571
C006780bisphenol Abisphenol A affects the expression of TFB2M mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TFB2M mRNA25181051
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M mRNA]20676402
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M protein]20676402
C018021cobaltous chloridecobaltous chloride results in increased expression of TFB2M mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of TFB2M mRNA21595052
D019327Copper SulfateCopper Sulfate results in decreased expression of TFB2M mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TFB2M mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of TFB2M mRNA28302478
D000069462Dimethyl FumarateDimethyl Fumarate results in increased expression of TFB2M mRNA27277809
D000069462Dimethyl FumarateNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]27277809
C024629dimethyl phthalatedimethyl phthalate affects the expression of TFB2M mRNA26924002
C100264enniatinsenniatins results in decreased expression of TFB2M mRNA27163883
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TFB2M mRNA23649840
D018120FinasterideFinasteride results in increased expression of TFB2M mRNA24136188
D005485FlutamideFlutamide results in increased expression of TFB2M mRNA24136188
D005839GentamicinsGentamicins results in increased expression of TFB2M mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of TFB2M mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TFB2M mRNA20044591
C492448ICG 001ICG 001 results in increased expression of TFB2M mRNA26191083
C051140iron(II)-ascorbic acid complexButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M mRNA]20676402
C051140iron(II)-ascorbic acid complexButylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M protein]20676402
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex results in increased expression of TFB2M mRNA20676402
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex results in increased expression of TFB2M protein20676402
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TFB2M mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TFB2M mRNA27392435
D007854LeadLead results in increased expression of TFB2M mRNA19921347
C045463leflunomideleflunomide results in decreased expression of TFB2M mRNA28988120
D001556LindaneLindane results in increased expression of TFB2M mRNA23777605
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TFB2M mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TFB2M mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TFB2M mRNA"25554681
C051752nefazodonenefazodone results in increased expression of TFB2M mRNA24136188
D009532NickelNickel results in decreased expression of TFB2M mRNA24084258
C012655nimesulidenimesulide results in increased expression of TFB2M mRNA24136188
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TFB2M protein26879310
C089730rosiglitazonerosiglitazone affects the expression of TFB2M mRNA22013433
D012643SeleniumSelenium results in decreased expression of TFB2M mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TFB2M mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TFB2M mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TFB2M mRNA28065790
D014212TretinoinTretinoin results in decreased expression of TFB2M mRNA23724009
D014635Valproic AcidValproic Acid affects the expression of TFB2M mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TFB2M gene25560391
C025643vinclozolinvinclozolin results in increased expression of TFB2M mRNA21126777
D014810Vitamin EVitamin E results in decreased expression of TFB2M mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000179rRNA (adenine-N6,N6-)-dimethyltransferase activity-IBA21873635  
GO:0003712transcription coregulator activity-IDA12068295  
GO:0003723RNA binding-HDA22681889  
GO ID GO Term Qualifier Evidence PubMed
GO:0006390mitochondrial transcription-IBA21873635  
GO:0006390mitochondrial transcription-IDA12068295  
GO:0006391transcription initiation from mitochondrial promoter-IDA20410300  
GO:0006391transcription initiation from mitochondrial promoter-TAS-  
GO:0007005mitochondrion organization-TAS-  
GO:0031167rRNA methylation-IBA21873635  
GO:0031167rRNA methylation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA20410300  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-IBA21873635  
GO:0005759mitochondrial matrix-IDA12068295  
GO:0005759mitochondrial matrix-TAS-  
GO:0042645mitochondrial nucleoid-IDA18063578  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-163282Mitochondrial transcription initiationTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75944Transcription from mitochondrial promotersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal