Gene: SFRP1

6422
FRP|FRP-1|FRP1|FrzA|SARP2
secreted frizzled related protein 1
protein-coding
8p11.21
Ensembl:ENSG00000104332 MIM:604156 Vega:OTTHUMG00000164074 UniprotKB:Q8N474
NC_000008.11
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.986e-1 (AD)  1.600e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RASGRP30.797
GREM10.782
ZEB20.779
ERMN0.761
PRR5L0.759
FAM107B0.757
FRMD4B0.756
CYB5R20.752
AIF1L0.751
OPALIN0.75

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.37
GRB14-0.37
EPN3-0.36
DBH-0.357
NEUROD1-0.34
GPR83-0.333
SPATA31C1-0.329
GPR55-0.317
HSD11B2-0.315
WIPF3-0.312

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SFRP1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SFRP1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SFRP1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SFRP1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SFRP1 mRNA"25510870
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of SFRP1 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
D000393Air PollutantsAir Pollutants analog results in increased expression of SFRP1 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SFRP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SFRP1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased methylation of SFRP1 gene28565807
C006632arsenic trioxidearsenic trioxide results in decreased methylation of SFRP1 promoter26966376
C006632arsenic trioxidearsenic trioxide results in increased expression of SFRP1 mRNA26966376|2856580
C006632arsenic trioxidearsenic trioxide results in increased expression of SFRP1 protein26966376|2856580
D001280AtrazineAtrazine results in increased expression of SFRP1 mRNA22378314
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SFRP1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SFRP1 mRNA21803694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SFRP1 mRNA21839799
D004958EstradiolEstradiol results in increased expression of SFRP1 mRNA19484750
D001645BiguanidesBiguanides analog affects the expression of SFRP1 mRNA17463086
C006780bisphenol Abisphenol A results in decreased expression of SFRP1 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of SFRP1 gene22576693
C006780bisphenol Abisphenol A results in decreased expression of SFRP1 mRNA25181051
D001761BleomycinBleomycin results in increased expression of SFRP1 mRNA26345256
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SFRP1 mRNA20147733|2207961
C584509C646 compoundC646 compound results in decreased expression of SFRP1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SFRP1 mRNA21457566
D002220CarbamazepineCarbamazepine affects the expression of SFRP1 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SFRP1 mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of SFRP1 mRNA26352163
D002794CholineCholine affects the expression of SFRP1 mRNA17616785
C007095cobaltiprotoporphyrincobaltiprotoporphyrin affects the expression of SFRP1 protein23497794
C007095cobaltiprotoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin affects the expression of SFRP1 protein]23497794
C018021cobaltous chloridecobaltous chloride results in decreased expression of SFRP1 mRNA19320972
C030973cupric oxidecupric oxide results in decreased expression of SFRP1 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of SFRP1 mRNA26577399|2752363
D003561CytarabineCytarabine results in increased expression of SFRP1 mRNA21198554
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SFRP1 mRNA23640034
C014347decitabinedecitabine affects the expression of SFRP1 mRNA18538736
C014347decitabinedecitabine affects the methylation of SFRP1 promoter17882284
C014347decitabine[decitabine affects the methylation of SFRP1 promoter] which affects the expression of SFRP1 mRNA18283316|1828331
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of SFRP1 mRNA17923031
C014347decitabinedecitabine results in decreased methylation of SFRP1 promoter19387464
C014347decitabinedecitabine results in increased expression of SFRP1 mRNA19234609|1938746
D003907DexamethasoneDexamethasone results in increased expression of SFRP1 mRNA16144937
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP1 mRNA16054899
D002945CisplatinCisplatin results in decreased expression of SFRP1 mRNA27392435
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of SFRP1 mRNA17490981
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SFRP1 mRNA27058323
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SFRP1 protein27058323
D004052Diethylnitrosamineepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]27058323
D004052Diethylnitrosamineepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein]27058323
D004052Diethylnitrosaminetheaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]27058323
D004052Diethylnitrosaminetheaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein]27058323
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SFRP1 mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SFRP1 mRNA"22485181
D004237DiuronDiuron results in decreased expression of SFRP1 mRNA25152437
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of SFRP1 mRNA25198161
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]27058323
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein]27058323
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SFRP1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SFRP1 mRNA16174780
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SFRP1 mRNA16174780
D002955LeucovorinLeucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 mRNA]25187349
D002955LeucovorinLeucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 protein]25187349
C010974glyphosateglyphosate results in decreased expression of SFRP1 mRNA26302742
D017313FenretinideFenretinide results in decreased expression of SFRP1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SFRP1 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of SFRP1 mRNA26191083
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP1 mRNA16054899
C008261lead acetatelead acetate affects the expression of SFRP1 mRNA21864555
C042720mercuric bromidemercuric bromide results in decreased expression of SFRP1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
D008628MercuryMercury results in decreased expression of SFRP1 mRNA19937285
D008727MethotrexateLeucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 mRNA]25187349
D008727MethotrexateLeucovorin inhibits the reaction [Methotrexate results in increased expression of SFRP1 protein]25187349
D008727MethotrexateMethotrexate results in increased expression of SFRP1 mRNA25187349
D008727MethotrexateMethotrexate results in increased expression of SFRP1 protein25187349
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFRP1 mRNA23519560
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SFRP1 mRNA28001369
D015735MifepristoneMifepristone results in increased expression of SFRP1 mRNA17584828
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SFRP1 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SFRP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SFRP1 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of SFRP1 mRNA18978301
D009532NickelNickel results in decreased expression of SFRP1 mRNA25583101
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of SFRP1 mRNA24888373
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SFRP1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of SFRP1 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of SFRP1 mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SFRP1 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SFRP1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SFRP1 mRNA25270620
D011073PolyaminesPolyamines analog affects the expression of SFRP1 mRNA17463086
D011073PolyaminesPolyamines analog affects the methylation of SFRP1 promoter19934284
D011073PolyaminesPolyamines analog results in increased expression of SFRP1 mRNA19934284
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of SFRP1 mRNA24888373
D017035PravastatinPravastatin results in increased expression of SFRP1 mRNA27225895
D011374ProgesteroneProgesterone results in decreased expression of SFRP1 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of SFRP1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SFRP1 mRNA15309432
C059514resveratrolresveratrol results in decreased expression of SFRP1 mRNA12569576
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP1 mRNA16054899
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of SFRP1 mRNA"21148743
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SFRP1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SFRP1 mRNA25351596|2709509
D012834SilverSilver results in decreased expression of SFRP1 mRNA27131904
D012834SilverSilver results in increased expression of SFRP1 mRNA27131904
D012906SmokeSmoke results in decreased expression of SFRP1 mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of SFRP1 mRNA21795629
D012999SomanSoman results in increased expression of SFRP1 mRNA19281266
D053260SootSoot results in increased expression of SFRP1 mRNA22461453|2655175
C001873sporidesminMIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]28193462
C001873sporidesminsporidesmin results in decreased expression of SFRP1 mRNA28193462
C075117squalestatin 1squalestatin 1 affects the expression of SFRP1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of SFRP1 mRNA27225895
D013629TamoxifenTamoxifen affects the expression of SFRP1 mRNA17555576
D013749TetrachlorodibenzodioxinAHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of SFRP1 mRNA]19759094
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SFRP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SFRP1 mRNA19759094
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFRP1 mRNA23519560
C056068theaflavintheaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 mRNA]27058323
C056068theaflavintheaflavin inhibits the reaction [Diethylnitrosamine results in decreased expression of SFRP1 protein]27058323
D013849ThimerosalThimerosal results in decreased expression of SFRP1 mRNA27188386
C055421tin mesoporphyrintin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin affects the expression of SFRP1 protein]23497794
C009495titanium dioxidetitanium dioxide results in increased expression of SFRP1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of SFRP1 promoter25214829
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SFRP1 mRNA20133372
D019772TopotecanSFRP1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SFRP1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SFRP1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of SFRP1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of SFRP1 mRNA23724009
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of SFRP1 mRNA17923031
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SFRP1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SFRP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SFRP1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of SFRP1 gene29154799
D014638VanadatesVanadates results in increased expression of SFRP1 mRNA22714537
D014640VancomycinVancomycin results in increased expression of SFRP1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SFRP1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SFRP1 mRNA26682919
D002762CholecalciferolCholecalciferol results in increased expression of SFRP1 mRNA17170073
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP1 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of SFRP1 mRNA26272509|2718838
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of SFRP1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-IMP14581477  
GO:0005109frizzled binding-IPI1927703  10347172  19277043  
GO:0005515protein binding-IPI10347172  
GO:0008144drug binding-IDA19072540  19254787  
GO:0008201heparin binding-IDA9192640  10660608  11741940  
GO:0017147Wnt-protein binding-IBA21873635  
GO:0017147Wnt-protein binding-IDA17462603  
GO:0017147Wnt-protein binding-IPI10347172  10660608  17462603  19072540  24080158  
GO:0017147Wnt-protein binding-NAS24431302  
GO:0042802identical protein binding-IPI10347172  
GO:0042813Wnt-activated receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-IEP16149051  
GO:0001657ureteric bud development-IEA-  
GO:0001954positive regulation of cell-matrix adhesion-ISS-  
GO:0002244hematopoietic progenitor cell differentiation-IDA19778523  
GO:0006508proteolysis-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0008284positive regulation of cell proliferation-IDA10980594  
GO:0008285negative regulation of cell proliferation-IDA10347172  17443492  17994217  19277043  20208569  
GO:0008584male gonad development-IEA-  
GO:0008585female gonad development-IEA-  
GO:0009267cellular response to starvation-IEP9724099  11932307  
GO:0009950dorsal/ventral axis specification-IDA9192640  
GO:0010564regulation of cell cycle process-IMP9724099  
GO:0010629negative regulation of gene expression-IDA10980594  
GO:0010719negative regulation of epithelial to mesenchymal transition-IDA19095296  
GO:0010975regulation of neuron projection development-IEA-  
GO:0014034neural crest cell fate commitment-IEA-  
GO:0014070response to organic cyclic compound-IDA20208569  
GO:0030177positive regulation of Wnt signaling pathway-IDA10660608  
GO:0030178negative regulation of Wnt signaling pathway-IDA9192640  10660608  17500071  20208569  
GO:0030178negative regulation of Wnt signaling pathway-IMP19072540  
GO:0030178negative regulation of Wnt signaling pathway-NAS24431302  
GO:0030279negative regulation of ossification-IDA15677765  
GO:0030279negative regulation of ossification-IMP19254787  
GO:0030307positive regulation of cell growth-IDA10980594  16288033  
GO:0030308negative regulation of cell growth-IDA19569235  20208569  
GO:0030336negative regulation of cell migration-IDA10980594  
GO:0030514negative regulation of BMP signaling pathway-IEA-  
GO:0033689negative regulation of osteoblast proliferation-IMP19072540  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0035567non-canonical Wnt signaling pathway-IBA21873635  
GO:0042493response to drug-IDA19072540  19254787  
GO:0043065positive regulation of apoptotic process-IDA9391078  15677765  
GO:0043065positive regulation of apoptotic process-IMP9724099  16149051  16288033  19254787  
GO:0043066negative regulation of apoptotic process-IMP11932307  14581477  16149051  16288033  19723665  
GO:0043508negative regulation of JUN kinase activity-IEA-  
GO:0043547positive regulation of GTPase activity-ISS-  
GO:0044344cellular response to fibroblast growth factor stimulus-IDA17500071  
GO:0044345stromal-epithelial cell signaling involved in prostate gland development-IEA-  
GO:0045578negative regulation of B cell differentiation-IMP18941195  
GO:0045600positive regulation of fat cell differentiation-IDA12055200  15886250  
GO:0045668negative regulation of osteoblast differentiation-IEA-  
GO:0045671negative regulation of osteoclast differentiation-IEA-  
GO:0045765regulation of angiogenesis-ISS-  
GO:0045880positive regulation of smoothened signaling pathway-IMP17035233  
GO:0045892negative regulation of transcription, DNA-templated-IDA10660608  19095296  19277043  20234818  
GO:0045892negative regulation of transcription, DNA-templated-IMP16532032  
GO:0045893positive regulation of transcription, DNA-templated-IDA10660608  15886250  19569235  
GO:0045893positive regulation of transcription, DNA-templated-IMP19723665  
GO:0046676negative regulation of insulin secretion-IDA17994217  
GO:0046851negative regulation of bone remodeling-IMP19072540  
GO:0048147negative regulation of fibroblast proliferation-IDA19734317  
GO:0048546digestive tract morphogenesis-IEA-  
GO:0050679positive regulation of epithelial cell proliferation-IMP16288033  
GO:0050680negative regulation of epithelial cell proliferation-IDA19095296  
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation-IDA10980594  
GO:0051496positive regulation of stress fiber assembly-ISS-  
GO:0051894positive regulation of focal adhesion assembly-ISS-  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IDA18787224  
GO:0060218hematopoietic stem cell differentiation-IDA19778523  
GO:0060346bone trabecula formation-IEA-  
GO:0060527prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis-IEA-  
GO:0060687regulation of branching involved in prostate gland morphogenesis-IEA-  
GO:0060766negative regulation of androgen receptor signaling pathway-IDA19277043  
GO:0071305cellular response to vitamin D-IEP16149051  
GO:0071347cellular response to interleukin-1-IEP16149051  
GO:0071356cellular response to tumor necrosis factor-IDA9391078  
GO:0071363cellular response to growth factor stimulus-IDA17500071  
GO:0071380cellular response to prostaglandin E stimulus-IEP16149051  
GO:0071391cellular response to estrogen stimulus-IDA18941195  
GO:0071392cellular response to estradiol stimulus-IEP11932307  
GO:0071456cellular response to hypoxia-IEP11932307  
GO:0071481cellular response to X-ray-IEA-  
GO:0071504cellular response to heparin-IDA17500071  
GO:0071542dopaminergic neuron differentiation-IEA-  
GO:0071560cellular response to transforming growth factor beta stimulus-IEP16149051  
GO:0071773cellular response to BMP stimulus-IEP16149051  
GO:0090090negative regulation of canonical Wnt signaling pathway-IBA21873635  
GO:0090090negative regulation of canonical Wnt signaling pathway-IDA9391078  10347172  16149051  16288033  17443492  17471511  19095296  19277043  19569235  
GO:0090090negative regulation of canonical Wnt signaling pathway-IGI17462603  24080158  
GO:0090090negative regulation of canonical Wnt signaling pathway-IMP9724099  16532032  17035233  
GO:0090179planar cell polarity pathway involved in neural tube closure-IEA-  
GO:0090244Wnt signaling pathway involved in somitogenesis-IEA-  
GO:0090246convergent extension involved in somitogenesis-IEA-  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA18941195  
GO:0090263positive regulation of canonical Wnt signaling pathway-IGI24080158  
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors-IDA9391078  
GO:1904956regulation of midbrain dopaminergic neuron differentiation-IEA-  
GO:2000041negative regulation of planar cell polarity pathway involved in axis elongation-IEA-  
GO:2000052positive regulation of non-canonical Wnt signaling pathway-IDA19569235  
GO:2000054negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification-IDA9192640  
GO:2000080negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation-IDA17994217  
GO:2000270negative regulation of fibroblast apoptotic process-IDA14581477  
GO:2000271positive regulation of fibroblast apoptotic process-IDA14581477  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA20551380  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA9192640  10980594  17500071  
GO:0005622intracellular-IDA17500071  
GO:0005829cytosol-IDA14581477  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-ISS-  
GO:0009986cell surface-IDA9192640  
GO:0016021integral component of membrane-IBA21873635  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrix-IDA9192640  10347172  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-195721Signaling by WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonistsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26413870Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth. (2015 Nov 2)Wang AJ Clin Invest
28421310Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)Strzelczyk JKBiochem Genet
16708382Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma. (2006 Oct 15)Marsit CJInt J Cancer