Gene: STRA6

64220
MCOPCB8|MCOPS9|PP14296
stimulated by retinoic acid 6
protein-coding
15q24.1
Ensembl:ENSG00000137868 MIM:610745 Vega:OTTHUMG00000138998 UniprotKB:Q9BX79
NG_009207.1
PubMed
0   ANCO-SNPs
ND
1   
6.506e-1 (AD)  3.501e-1 (ND)   (Frontal_Cortex)
4.754e-1 (AD)  9.439e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GADL10.781
FER1L60.77
FCER20.752
BMP50.723
UBL4B0.717
GSDMA0.7
SLC9C10.7
FMO10.698
KRTAP9-30.697
CD960.693

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.384
SLC1A4-0.368
NDP-0.367
DBP-0.366
PURG-0.362
CADM1-0.356
ASPDH-0.355
GDF9-0.347
FUT9-0.345
HDAC11-0.343

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of STRA6 mRNA"25710175
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased expression of STRA6 mRNA25716159
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of STRA6 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of STRA6 gene27153756
C430898AGN 194204AGN 194204 results in increased expression of STRA6 mRNA16339527
D000393Air PollutantsAir Pollutants analog results in decreased expression of STRA6 mRNA21757418
C006632arsenic trioxidearsenic trioxide results in decreased expression of STRA6 mRNA22521957
C015001arsenitearsenite results in decreased methylation of STRA6 promoter23974009
D001507BeclomethasoneBeclomethasone results in increased expression of STRA6 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STRA6 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of STRA6 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STRA6 mRNA27195522
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of STRA6 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of STRA6 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of STRA6 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of STRA6 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of STRA6 mRNA26496021
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of STRA6 mRNA22079614
D002509CephaloridineCephaloridine results in decreased expression of STRA6 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of STRA6 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of STRA6 mRNA18353800
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of STRA6 mRNA24317228
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of STRA6 mRNA]27941970
C016366dibenzothiophenedibenzothiophene results in increased expression of STRA6 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of STRA6 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of STRA6 mRNA27392435
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of STRA6 mRNA25242112
D004147DioxinsDioxins affects the expression of STRA6 mRNA20463971
D004237DiuronDiuron results in increased expression of STRA6 mRNA25152437
C118739entinostatentinostat results in increased expression of STRA6 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STRA6 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of STRA6 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of STRA6 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of STRA6 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of STRA6 mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of STRA6 mRNA27392435
C544151jinfukangjinfukang results in increased expression of STRA6 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STRA6 mRNA24796395|2675264
C029310lardlard results in increased expression of STRA6 mRNA26115784
C008261lead acetatelead acetate affects the expression of STRA6 mRNA21864555
D008694MethamphetamineMethamphetamine results in decreased expression of STRA6 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of STRA6 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of STRA6 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STRA6 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of STRA6 mRNA23649840
C025589ochratoxin Aochratoxin A results in increased expression of STRA6 mRNA19717638
D017239PaclitaxelPaclitaxel results in increased expression of STRA6 mRNA18754875
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of STRA6 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of STRA6 mRNA23811191
D011441PropylthiouracilPropylthiouracil results in increased expression of STRA6 mRNA24780913
C534628SCH 23390SCH 23390 affects the expression of STRA6 mRNA19564919
D012822Silicon DioxideSilicon Dioxide results in decreased expression of STRA6 mRNA25351596
C016104sodium bichromatesodium bichromate results in decreased expression of STRA6 mRNA24612858
D013629TamoxifenTamoxifen affects the expression of STRA6 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of STRA6 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STRA6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of STRA6 mRNA17942748
D019284ThapsigarginThapsigargin results in decreased expression of STRA6 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of STRA6 mRNA28065790
D014050TolueneToluene results in increased expression of STRA6 mRNA22967744
D014212TretinoinTretinoin results in increased expression of STRA6 mRNA21934132|2383079
D014212TretinoinTretinoin results in increased expression of STRA6 mRNA16604517
D014212TretinoinTretinoin results in increased expression of STRA6 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of STRA6 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of STRA6 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of STRA6 mRNA24896083
D014801Vitamin ASTRA6 protein results in increased uptake of Vitamin A17255476
D014801Vitamin ASTRA6 protein affects the abundance of Vitamin A18316031
D014801Vitamin A[STRA6 protein co-treated with LRAT protein] results in increased uptake of Vitamin A18316031
D014801Vitamin ASTRA6 protein results in increased transport of Vitamin A18316031
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STRA6 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of STRA6 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016918retinal binding-IEA-  
GO:0019841retinol binding-IEA-  
GO:0034632retinol transmembrane transporter activity-IDA21901792  
GO:0038023signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0001568blood vessel development-IMP17273977  
GO:0001822kidney development-IMP17273977  
GO:0003184pulmonary valve morphogenesis-IMP17273977  
GO:0003281ventricular septum development-IMP17273977  
GO:0007165signal transduction-IEA-  
GO:0007507heart development-IMP17273977  
GO:0007612learning-IMP17273977  
GO:0007631feeding behavior-IMP17273977  
GO:0030324lung development-IMP17273977  
GO:0030325adrenal gland development-IMP17273977  
GO:0030540female genitalia development-IMP17273977  
GO:0034633retinol transport-IDA21901792  
GO:0042297vocal learning-IMP17273977  
GO:0043010camera-type eye development-IMP21901792  
GO:0043583ear development-IMP17273977  
GO:0043585nose morphogenesis-IMP17273977  
GO:0048286lung alveolus development-IMP17273977  
GO:0048520positive regulation of behavior-IMP17273977  
GO:0048546digestive tract morphogenesis-IMP17273977  
GO:0048566embryonic digestive tract development-IMP17273977  
GO:0048589developmental growth-IMP17273977  
GO:0048745smooth muscle tissue development-IMP17273977  
GO:0048844artery morphogenesis-IMP17273977  
GO:0050890cognition-IMP17273977  
GO:0050905neuromuscular process-IMP17273977  
GO:0060322head development-IMP17273977  
GO:0060323head morphogenesis-IMP17273977  
GO:0060325face morphogenesis-IMP17273977  
GO:0060426lung vasculature development-IMP17273977  
GO:0060539diaphragm development-IMP17273977  
GO:0060900embryonic camera-type eye formation-IMP17273977  
GO:0061029eyelid development in camera-type eye-IMP17273977  
GO:0061038uterus morphogenesis-IMP17273977  
GO:0061143alveolar primary septum development-IMP17273977  
GO:0061156pulmonary artery morphogenesis-IMP17273977  
GO:0061205paramesonephric duct development-IMP17273977  
GO:0071939vitamin A import-IBA21873635  
GO:0097070ductus arteriosus closure-IMP19500772  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA21901792  
GO:0032991protein-containing complex-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-2453864Retinoid cycle disease eventsTAS
R-HSA-2453902The canonical retinoid cycle in rods (twilight vision)TAS
R-HSA-2474795Diseases associated with visual transductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-5663202Diseases of signal transductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27446956Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese. (2016)Huang HWBiomed Res Int