Gene: ROBO3

64221
HGPPS|HGPPS1|HGPS|RBIG1|RIG1
roundabout guidance receptor 3
protein-coding
11q24.2
Ensembl:ENSG00000154134 MIM:608630 Vega:OTTHUMG00000165934 UniprotKB:Q96MS0
NG_016214.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.606e-1 (AD)  6.289e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCAT20.826
ECHDC20.799
XRCC30.796
SLC44A20.792
RAPGEF30.791
SEMA4B0.788
MICALL20.782
CASKIN20.779
PLD20.772
PLXNB20.764

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.449
OR4F29-0.415
EGFL6-0.358
CRH-0.338
IGF1-0.336
ADAMTS5-0.336
HAPLN1-0.332
OSTN-0.313
BEND4-0.306
FREM3-0.302

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO3 mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ROBO3 mRNA24449571
D001151ArsenicArsenic affects the methylation of ROBO3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ROBO3 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of ROBO3 mRNA26364221
C006780bisphenol A[potassium bromate co-treated with bisphenol A] affects the expression of ROBO3 mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of ROBO3 mRNA]27082013
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of ROBO3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ROBO3 mRNA25181051
D000068579CelecoxibCelecoxib results in increased expression of ROBO3 mRNA28201806
D019327Copper SulfateCopper Sulfate results in increased expression of ROBO3 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of ROBO3 mRNA26577399
D003561CytarabineCytarabine results in increased expression of ROBO3 mRNA21198554
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ROBO3 mRNA]27941970
D005047EtoposideEtoposide results in increased expression of ROBO3 mRNA21527772
C544151jinfukangjinfukang results in increased expression of ROBO3 mRNA27392435
C042720mercuric bromidemercuric bromide results in decreased expression of ROBO3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO3 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ROBO3 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ROBO3 mRNA20864626
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ROBO3 mRNA24810058
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of ROBO3 mRNA27935865
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ROBO3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ROBO3 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of ROBO3 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of ROBO3 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of ROBO3 mRNA23557933
C019536potassium bromatepotassium bromate affects the expression of ROBO3 mRNA27082013
C019536potassium bromate[potassium bromate co-treated with bisphenol A] affects the expression of ROBO3 mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of ROBO3 mRNA]27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of ROBO3 mRNA]27082013
D011372ProgestinsProgestins results in decreased expression of ROBO3 mRNA19609016
D011441PropylthiouracilPropylthiouracil results in decreased expression of ROBO3 mRNA24780913
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of ROBO3 mRNA17540011
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of ROBO3 mRNA26496021
D014212TretinoinTretinoin results in decreased expression of ROBO3 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ROBO3 mRNA19042947
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ROBO3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI26586761  
GO ID GO Term Qualifier Evidence PubMed
GO:0007411axon guidance-NAS15105459  
GO:0016199axon midline choice point recognition-ISS-  
GO:0035385Roundabout signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-NAS15105459  
GO:0030424axon-IEA-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBOIEA
R-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBOTAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9010642ROBO receptors bind AKAP5TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24398667Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers. (2014 Jun)Tessema MCarcinogenesis
20651036Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. (2010 Dec)Duncan WCMol Hum Reprod