Gene info: ID 6423

Gene: SFRP2

GENE ID: 6423

Synonyms: FRP-2|SARP1|SDF-5

Description: secreted frizzled related protein 2

Gene type: protein-coding

Location: 4q31.3

dbXrefs: Ensembl:ENSG00000145423 MIM:604157 Vega:OTTHUMG00000161559 UniprotKB:Q96HF1

RefSeq: NG_046941.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.714e-1 (AD) 2.522e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GLP1R	0.638
MSX2	0.638
IGFBP5	0.624
ELN	0.58
SEMA3C	0.541
PFKFB2	0.54
LPAR4	0.53
USH1C	0.527
CNGA3	0.516
GPC6	0.506

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TEX38	-0.228
C20orf85	-0.227
OR4F5	-0.227
OR4F29	-0.218
MTRNR2L10	-0.216
OR4F16	-0.208
CYP4F22	-0.196
MTRNR2L6	-0.184
LAIR2	-0.182
GRHL2	-0.174

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C006718	1,12-benzoperylene	"1,12-benzoperylene results in increased expression of SFRP2 mRNA"	26377693
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SFRP2 mRNA	19933214
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene results in increased expression of SFRP2 mRNA"	20406850
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SFRP2 mRNA	16788091
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SFRP2 mRNA	22129741
D020106	Acrylamide	Acrylamide results in decreased expression of SFRP2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of SFRP2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of SFRP2 mRNA	28943387
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SFRP2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of SFRP2 mRNA	24449571
C000228	aristolochic acid I	aristolochic acid I results in decreased expression of SFRP2 mRNA	17483316
D001149	Arsenates	[Atrazine co-treated with Arsenates] results in increased expression of SFRP2 mRNA	18585445
D001151	Arsenic	Arsenic affects the methylation of SFRP2 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SFRP2 mRNA	22521957\|2670570
C015001	arsenite	arsenite results in increased methylation of SFRP2 promoter	23974009
D001280	Atrazine	[Atrazine co-treated with Arsenates] results in increased expression of SFRP2 mRNA	18585445
C547126	AZM551248	AZM551248 results in increased expression of SFRP2 mRNA	22323515
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of SFRP2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SFRP2 mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SFRP2 mRNA	22228805
D004958	Estradiol	Estradiol results in decreased expression of SFRP2 mRNA	14664709\|1764099
D004958	Estradiol	Estradiol results in decreased expression of SFRP2 mRNA	26945725
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SFRP2 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of SFRP2 mRNA	22504913
C006780	bisphenol A	bisphenol A results in increased expression of SFRP2 mRNA	25963729
C006780	bisphenol A	Curcumin inhibits the reaction [bisphenol A results in increased expression of SFRP2 mRNA]	25963729
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SFRP2 mRNA	28628672
C099813	bromochloroacetic acid	bromochloroacetic acid results in decreased expression of SFRP2 protein	21296659
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SFRP2 mRNA	12160620
C031180	chrysene	chrysene results in increased expression of SFRP2 mRNA	26377693
D003471	Cuprizone	Cuprizone results in increased expression of SFRP2 mRNA	27523638
D003474	Curcumin	Curcumin inhibits the reaction [bisphenol A results in increased expression of SFRP2 mRNA]	25963729
D003474	Curcumin	Curcumin results in decreased expression of SFRP2 mRNA	25963729
D016572	Cyclosporine	Cyclosporine results in decreased expression of SFRP2 mRNA	21865292
D003561	Cytarabine	Cytarabine results in increased expression of SFRP2 mRNA	21198554
C014347	decitabine	decitabine affects the methylation of SFRP2 promoter	17848950\|1788228
C014347	decitabine	[decitabine affects the methylation of SFRP2 promoter] which affects the expression of SFRP2 mRNA	18283316\|1828331
C014347	decitabine	[decitabine affects the methylation of SFRP2 protein] which affects the expression of SFRP2 mRNA	18404682\|1840468
C014347	decitabine	[decitabine affects the methylation of SFRP2 protein] which affects the expression of SFRP2 protein	18404682
C014347	decitabine	[decitabine co-treated with trichostatin A] results in increased expression of SFRP2 mRNA	17923031
C014347	decitabine	decitabine results in decreased methylation of SFRP2 promoter	19387464
C014347	decitabine	decitabine results in increased expression of SFRP2 mRNA	19387464
C107676	deguelin	deguelin results in decreased expression of SFRP2 mRNA	19861542
D003907	Dexamethasone	Dexamethasone results in decreased expression of SFRP2 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SFRP2 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SFRP2 mRNA	28628672
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP2 mRNA	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SFRP2 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of SFRP2 mRNA	21151649
D004026	Dieldrin	Dieldrin results in increased expression of SFRP2 mRNA	28385952
D004041	Dietary Fats	Dietary Fats results in decreased expression of SFRP2 mRNA	18042831
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SFRP2 mRNA	22129741
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SFRP2 mRNA	21658437
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of SFRP2 mRNA"	22485181
D004237	Diuron	Diuron results in increased expression of SFRP2 mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in decreased expression of SFRP2 mRNA	25896364
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of SFRP2 mRNA	21040762
C118739	entinostat	entinostat results in decreased expression of SFRP2 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFRP2 mRNA	17942748
D004397	Fonofos	Fonofos results in increased methylation of SFRP2 promoter	22847954
C039281	furan	furan results in decreased methylation of SFRP2 gene	27387713
C039281	furan	furan results in increased expression of SFRP2 mRNA	27387713
D019833	Genistein	Genistein results in decreased expression of SFRP2 mRNA	22504913
D019833	Genistein	Genistein results in increased expression of SFRP2 mRNA	17341692
D005944	Glucosamine	Glucosamine results in decreased expression of SFRP2 mRNA	17109745
D017313	Fenretinide	Fenretinide results in decreased expression of SFRP2 mRNA	28973697
C029424	hydrazine	hydrazine results in decreased expression of SFRP2 mRNA	15282401
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SFRP2 mRNA	22129741
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SFRP2 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SFRP2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SFRP2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SFRP2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP2 mRNA	16054899
C008261	lead acetate	lead acetate results in decreased expression of SFRP2 mRNA	22613225
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SFRP2 mRNA	12057914
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of SFRP2 mRNA	20069066
D018021	Lithium Chloride	SFRP2 protein affects the reaction [Lithium Chloride results in increased expression of CTNNB1 mRNA]	20069066
D018021	Lithium Chloride	SFRP2 protein affects the reaction [Lithium Chloride results in increased expression of NANOG mRNA]	20069066
D018021	Lithium Chloride	SFRP2 protein affects the reaction [Lithium Chloride results in increased expression of POU5F1 mRNA]	20069066
D019808	Losartan	SFRP2 protein results in decreased susceptibility to Losartan	23875703
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in decreased expression of SFRP2 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in decreased expression of SFRP2 mRNA	19564919
D008748	Methylcholanthrene	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFRP2 mRNA	23519560
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SFRP2 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SFRP2 mRNA"	20188158
D009151	Mustard Gas	Mustard Gas results in decreased expression of SFRP2 mRNA	15674843
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SFRP2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SFRP2 mRNA"	25554681
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SFRP2 mRNA	27935865
C025589	ochratoxin A	ochratoxin A results in increased expression of SFRP2 mRNA	23358140
D000073878	Palm Oil	Palm Oil results in decreased expression of SFRP2 mRNA	18042831
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of SFRP2 mRNA	26272509
D010278	Parathion	Parathion results in increased methylation of SFRP2 promoter	22847954
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in decreased expression of SFRP2 mRNA	22790973
C011272	perfosfamide	perfosfamide results in decreased expression of SFRP2 mRNA	19429390
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of SFRP2 mRNA	26272509
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SFRP2 mRNA	27935865
D011073	Polyamines	Polyamines analog affects the methylation of SFRP2 promoter	19934284
D011073	Polyamines	Polyamines analog results in increased expression of SFRP2 mRNA	19934284
D011374	Progesterone	Progesterone results in decreased expression of SFRP2 mRNA	19690047
D011441	Propylthiouracil	Propylthiouracil results in increased expression of SFRP2 mRNA	24780913
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of SFRP2 mRNA	16054899
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in decreased expression of SFRP2 mRNA	19564919
C534628	SCH 23390	SCH 23390 results in decreased expression of SFRP2 mRNA	19564919
C017947	sodium arsenite	sodium arsenite results in decreased expression of SFRP2 mRNA	20179202
D013629	Tamoxifen	Tamoxifen results in increased expression of SFRP2 mRNA	25123088
C012568	terbufos	terbufos results in increased methylation of SFRP2 promoter	22847954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFRP2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SFRP2 mRNA	28077779
D013755	Tetradecanoylphorbol Acetate	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFRP2 mRNA	23519560
D013792	Thalidomide	Thalidomide results in decreased expression of SFRP2 mRNA	28892372
D013792	Thalidomide	Thalidomide results in increased expression of SFRP2 mRNA	26217789
C009495	titanium dioxide	titanium dioxide affects the expression of SFRP2 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SFRP2 mRNA	20133372
D014212	Tretinoin	Tretinoin results in decreased expression of SFRP2 mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of SFRP2 mRNA	20488242
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in increased expression of SFRP2 mRNA	17923031
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
C012589	trichostatin A	[trichostatin A affects the methylation of SFRP2 protein] which affects the expression of SFRP2 mRNA	18404682\|1840468
C012589	trichostatin A	[trichostatin A affects the methylation of SFRP2 protein] which affects the expression of SFRP2 protein	18404682
C012589	trichostatin A	trichostatin A results in decreased expression of SFRP2 mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in increased expression of SFRP2 mRNA	28973697
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SFRP2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of SFRP2 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased expression of SFRP2 mRNA	24849673
D014635	Valproic Acid	Valproic Acid results in increased expression of SFRP2 mRNA	24896083
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SFRP2 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of SFRP2 mRNA	19165385
C025643	vinclozolin	vinclozolin results in increased expression of SFRP2 mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001968	fibronectin binding	-	ISS	-
GO:0005178	integrin binding	-	ISS	-
GO:0017147	Wnt-protein binding	-	IBA	21873635
GO:0017147	Wnt-protein binding	-	NAS	24431302
GO:0042813	Wnt-activated receptor activity	-	IBA	21873635
GO:0048018	receptor ligand activity	-	ISS	-
GO:0061133	endopeptidase activator activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001569	branching involved in blood vessel morphogenesis	-	ISS	-
GO:0002063	chondrocyte development	-	IEA	-
GO:0003151	outflow tract morphogenesis	-	IMP	19593212
GO:0003214	cardiac left ventricle morphogenesis	-	IMP	19593212
GO:0006915	apoptotic process	-	IEA	-
GO:0007186	G-protein coupled receptor signaling pathway	-	IEA	-
GO:0007267	cell-cell signaling	-	ISS	-
GO:0007584	response to nutrient	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IDA	10980594
GO:0008285	negative regulation of cell proliferation	-	IDA	20208569
GO:0008285	negative regulation of cell proliferation	-	IMP	17848950
GO:0008584	male gonad development	-	IEA	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0010629	negative regulation of gene expression	-	ISS	10980594
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	-	IEA	-
GO:0010719	negative regulation of epithelial to mesenchymal transition	-	IDA	19095296
GO:0010950	positive regulation of endopeptidase activity	-	IEA	-
GO:0010975	regulation of neuron projection development	-	IEA	-
GO:0030178	negative regulation of Wnt signaling pathway	-	IDA	20208569
GO:0030178	negative regulation of Wnt signaling pathway	-	NAS	24431302
GO:0030199	collagen fibril organization	-	IEA	-
GO:0030307	positive regulation of cell growth	-	ISS	10980594
GO:0030308	negative regulation of cell growth	-	IDA	20208569
GO:0030336	negative regulation of cell migration	-	ISS	10980594
GO:0030514	negative regulation of BMP signaling pathway	-	IEA	-
GO:0031668	cellular response to extracellular stimulus	-	IEA	-
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	ISS	-
GO:0033630	positive regulation of cell adhesion mediated by integrin	-	ISS	-
GO:0035567	non-canonical Wnt signaling pathway	-	IBA	21873635
GO:0036342	post-anal tail morphogenesis	-	IEA	-
GO:0042493	response to drug	-	IEA	-
GO:0042662	negative regulation of mesodermal cell fate specification	-	IEA	-
GO:0042733	embryonic digit morphogenesis	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IMP	17848950
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IEA	-
GO:0043508	negative regulation of JUN kinase activity	-	IEA	-
GO:0045600	positive regulation of fat cell differentiation	-	IDA	12055200
GO:0045669	positive regulation of osteoblast differentiation	-	IEA	-
GO:0045766	positive regulation of angiogenesis	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	19095296
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0048546	digestive tract morphogenesis	-	IEA	-
GO:0050680	negative regulation of epithelial cell proliferation	-	IDA	19095296
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	-	ISS	10980594
GO:0060028	convergent extension involved in axis elongation	-	IEA	-
GO:0060070	canonical Wnt signaling pathway	-	IBA	21873635
GO:0060349	bone morphogenesis	-	IEA	-
GO:0061056	sclerotome development	-	ISS	-
GO:0061185	negative regulation of dermatome development	-	ISS	-
GO:0071425	hematopoietic stem cell proliferation	-	ISS	-
GO:0071481	cellular response to X-ray	-	IEA	-
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IBA	21873635
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IDA	17471511
GO:0090179	planar cell polarity pathway involved in neural tube closure	-	IEA	-
GO:0090244	Wnt signaling pathway involved in somitogenesis	-	IEA	-
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	ISS	-
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	-	IEA	-
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	-	ISS	-
GO:1904956	regulation of midbrain dopaminergic neuron differentiation	-	IEA	-
GO:2000035	regulation of stem cell division	-	ISS	-
GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	10980594
GO:0005615	extracellular space	-	ISS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0016021	integral component of membrane	-	IBA	21873635
GO:0062023	collagen-containing extracellular matrix	-	ISS	-

KEGG ID	KEGG Term
hsa04310	Wnt signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	IEA
R-HSA-195721	Signaling by WNT	IEA
R-HSA-201681	TCF dependent signaling in response to WNT	IEA
R-HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21490961	Down-regulation of the canonical Wnt beta-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. (2011 Apr 7)	Wang R	PLoS One
28421310	Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer. (2017 Aug)	Strzelczyk JK	Biochem Genet
27110300	The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. (2016)	Ma K	Clin Epigenetics
22083596	Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. (2012 May 15)	Kisiel JB	Cancer
16708382	Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma. (2006 Oct 15)	Marsit CJ	Int J Cancer